Results 121 to 130 of about 8,521 (239)

Platelet Hyaluronan Synthase 3 Regulates Thrombin Signaling and Adhesion to Fibrinogen Under Venous Shear

Proteoglycan Research, Volume 3, Issue 3, July 2025.
ABSTRACT Hyaluronan (HA) is an essential glycosaminoglycan with supportive roles in hematopoiesis. HA is synthesized by hyaluronan synthases (HAS1, HAS2, and HAS3) and plays a crucial role in cellular signaling and extracellular matrix interactions.
Kimberly A. Queisser, Lydia Smith, Gabriel Leung, Nansy Albtoush, Rebecca A. Mellema, Aaron C. Petrey   +5 more
wiley   +1 more source

G6f-like is an ITAM-containing collagen receptor in thrombocytes.

PLoS ONE, 2012
Collagen activates mammalian platelets through a complex of the immunoglobulin (Ig) receptor GPVI and the Fc receptor γ-chain, which has an immunoreceptor tyrosine-based activation motif (ITAM).
Craig E Hughes, Uvaraj P Radhakrishnan, Marie Lordkipanidzé, Stuart Egginton, Johannes M Dijkstra, Pudur Jagadeeswaran, Stephen P Watson   +6 more
doaj   +1 more source

Plasma levels of the soluble form of the FcγRIIa receptor vary with receptor polymorphisms and are elevated in rheumatoid arthritis

Platelets, 2020
Soluble forms of the low-affinity immunoglobulin receptor FcγRIIa (sFcγRIIa) lacking the cytoplasmic tail have been reported in plasma however the mechanism and functional consequences are unknown.
Jianlin Qiao, Eimear Dunne, Bruce Wines, Dermot Kenny, Geraldine M. McCarthy, P. Mark Hogarth, Kailin Xu, Robert K. Andrews, Elizabeth E. Gardiner   +8 more
doaj   +1 more source

CalDAG-GEFI deficiency protects mice in a novel model of FcγRIIA-mediated thrombosis and thrombocytopenia [PDF]

, 2011
Platelet activation via Fcγ receptor IIA (FcγRIIA) is a critical event in immune-mediated thrombocytopenia and thrombosis syndromes (ITT). We recently identified signaling by the guanine nucleotide exchange factor CalDAG-GEFI and the adenosine ...
André, Pierrette, Bergmeier, Wolfgang, Mckenzie, Steven E., Ouellette, Timothy D., Reilly, Michael P., Stefanini, Lucia, Stolla, Moritz   +6 more
core   +1 more source

Differential Inhibition of Human Atherosclerotic Plaque–Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies

Journal of the American College of Cardiology, 2015
Glycoprotein VI (GPVI) is the essential platelet collagen receptor in atherothrombosis, but its inhibition causes only a mild bleeding tendency. Thus, targeting this receptor has selective antithrombotic potential.This study sought to compare compounds interfering with platelet GPVI-atherosclerotic plaque interaction to improve current ...
Jamasbi, Janina, Megens, Remco TA, Bianchini, Mariaelvy, Münch, Götz, Ungerer, Martin, Faussner, Alexander, Sherman, Shachar, Walker, Adam, Goyal, Pankaj, Jung, Stephanie, Brandl, Richard, Weber, Christian, Lorenz, Reinhard, Farndale, Richard, Elia, Natalie, Siess, Wolfgang   +15 more
openaire   +3 more sources

Regulation of platelet membrane protein shedding in health and disease

Platelets, 2017
Extracellular proteolysis of platelet plasma membrane proteins is an event that ensues platelet activation. Shedding of surface receptors such as glycoprotein (GP) Ibα, GPV and GPVI as well as externalized proteins P-selectin and CD40L releases soluble ...
Amanda E. Au, Emma C. Josefsson
doaj   +1 more source

The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation

Redox Biology, 2014
Background: Activation of the platelet-specific collagen receptor, glycoprotein (GP) VI, induces intracellular reactive oxygen species (ROS) production; however the relevance of ROS to GPVI-mediated platelet responses remains unclear.
T.G. Walsh, M.C. Berndt, N. Carrim, J. Cowman, D. Kenny, P. Metharom   +5 more
doaj   +1 more source

GPIb potentiates GPVI-induced responses in human platelets

Platelets, 2004
Platelet adhesion to vascular subendothelial proteins at the site of blood vessel injury is critical for initiating haemostasis. Collagen is a major matrix protein that binds plasma von Willebrand factor (vWF) when the endothelium becomes damaged and therefore in vivo platelets are likely to encounter both of these agonists simultaneously, through ...
Rebecca L. Griggs, Julie Baker, Alastair W. Poole, Shahrokh Falati   +3 more
openaire   +2 more sources

Platelet signalling networks: pathways perturbation demonstrates differential sensitivity of ADP secretion and fibinogen binding. [PDF]

, 2011
Platelet signalling responses to single agonists have been identified previously. However a model of the total platelet signalling network is still lacking.
De Chaumont, Ciaran, Lombardi, Federica, Moran, Niamh, Shields, Denis C   +3 more
core   +1 more source

Systems biology of platelet-vessel wall interactions [PDF]

, 2014
Platelets are small, anucleated cells that participate in primary hemostasis by forming a hemostatic plug at the site of a blood vessel's breach, preventing blood loss.
A Angelillo-Scherrer, A Kauskot, A Kita, AD Michelson, AL Fogelson, AL Kuharsky, B Engelmann, C Gachet, C Gieger, C Schulz, C Thery, CI Jones, D Boyanova, D Duerschmied, D Schumacher, D Tsikas, DB Cines, DD Wagner, E Berrou, E Boilard, E Pena, E Westein, EM Battinelli, F Graner, G Raposo, G Zhang, H Falet, HF Heijnen, HH Versteeg, IC Macaulay, IV Pivkin, JA Coppinger, JE Italiano Jr, JE Italiano Jr, JL Sylman, JM Burkhart, JW Rowley, K Chen, K Leiderman, K Leiderman, K Martinod, KD Mason, L Zhu, M Demers, M Dittrich, M Dittrich, M Dittrich, M Labelle, M Schaff, MH Flamm, MH Flamm, ML Bruhl von, MT Rondina, N Begent, N Prevost, NA Mody, O Borst, OV Kim, P Nurden, PY Huang, PY Huang, PY Huang, R Darbousset, RS Voronov, S Feng, S Gambaryan, S Jupe, S Vaiyapuri, SF Mause, SL Diamond, SP Jackson, T Skorczewski, T Torisu, TA Fuchs, TJ Stalker, TJ Stalker, TJ Stalker, WA Lam, YA Senis, Z Li, Z Xu, Z Xu, Z Xu, Z Xu, Z Xu   +84 more
core   +1 more source