Results 121 to 130 of about 8,890 (226)

Charakteristik der Thrombozyten-Oberflächenexpression von Glycoprotein VI bei Diabetes mellitus Typ 2 [PDF]

, 2006
The present analysis investigated the role of GPVI for platelet activation and platelet-mediated endothelial activation in patients with type 2 diabetes.
Li, Zhongyan
core  

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2 [PDF]

, 2008
Background: The adapter proteins SLP-76 and LAT have been shown to play critical roles in the activation of PLCc2 in platelets downstream of GPVI/FcRc and the C-type lectin receptor CLEC-2.
Abtahian, Aguado, Andrews, Auger, Booth, Clements, Clements, Dawood, Eble, Finco, Fuller, Garcia, Hughan, Huysamen, Ishiai, Jordan, Judd, Judd, Kalia, Liu, Liu, McCarty, McCarty, Pasquet, Paz, Perez-Villar, Sarratt, Seet, Shen, Sommers, Suzuki-Inoue, Suzuki-Inoue, Tomlinson, Yablonski, Yablonski, Yoder, Zhang, Zhang, Zhang   +38 more
core   +2 more sources

Clinical significance of receptor shedding-platelet GPVI as an emerging diagnostic and therapeutic tool

Platelets, 2017
Platelet membrane bedecked with a wide array of receptors offers a platform to regulate platelet responsiveness, thrombotic propensity, inflammatory disposition, and immune reactivity under diverse pathophysiological conditions.
Madhumita Chatterjee, Meinrad Gawaz
doaj   +1 more source

High-throughput elucidation of thrombus formation reveals sources of platelet function variability

Haematologica, 2019
In combination with microspotting, whole-blood microfluidics can provide high-throughput information on multiple platelet functions in thrombus formation.
Johanna P. van Geffen, Sanne L.N. Brouns, Joana Batista, Harriet McKinney, Carly Kempster, Magdolna Nagy, Suthesh Sivapalaratnam, Constance C.F.M.J. Baaten, Nikki Bourry, Mattia Frontini, Kerstin Jurk, Manuela Krause, Daniele Pillitteri, Frauke Swieringa, Remco Verdoold, Rachel Cavill, Marijke J. E. Kuijpers, Willem H. Ouwehand, Kate Downes, Johan W.M. Heemskerk   +19 more
doaj   +1 more source

The Adverse Impact of Tyrosine Kinase Inhibitors on Wound Healing and Repair

International Wound Journal, Volume 22, Issue 4, April 2025.
ABSTRACT Tyrosine kinase inhibitors (TKIs) can treat various cancers, primarily through their antiangiogenic effects. However, as angiogenesis is crucial for successful wound healing, TKIs may adversely impact wound repair. This review analysed all 63 FDA‐approved TKIs and identified evidence for wound healing and repair implications in 24 agents.
William J. Nahm, Vincent Falanga
wiley   +1 more source

Plasma levels of the soluble form of the FcγRIIa receptor vary with receptor polymorphisms and are elevated in rheumatoid arthritis

Platelets, 2020
Soluble forms of the low-affinity immunoglobulin receptor FcγRIIa (sFcγRIIa) lacking the cytoplasmic tail have been reported in plasma however the mechanism and functional consequences are unknown.
Jianlin Qiao, Eimear Dunne, Bruce Wines, Dermot Kenny, Geraldine M. McCarthy, P. Mark Hogarth, Kailin Xu, Robert K. Andrews, Elizabeth E. Gardiner   +8 more
doaj   +1 more source

Rapid ubiquitination of Syk following GPVI activation in platelets [PDF]

Blood, 2005
AbstractSpleen tyrosine kinase (Syk) activation is a key intermediate step in the activation of platelets by the physiologic agonist collagen. We have found that Syk is rapidly ubiquitinated upon activation of platelets by collagen, collagen-related peptide (CRP), and convulxin.
Satya P. Kunapuli, Jianguo Jin, Patricia G. Quinter, Alexander Y. Tsygankov, Carol Dangelmaier, James L. Daniel   +5 more
openaire   +3 more sources

Regulation of platelet membrane protein shedding in health and disease

Platelets, 2017
Extracellular proteolysis of platelet plasma membrane proteins is an event that ensues platelet activation. Shedding of surface receptors such as glycoprotein (GP) Ibα, GPV and GPVI as well as externalized proteins P-selectin and CD40L releases soluble ...
Amanda E. Au, Emma C. Josefsson
doaj   +1 more source

Gaudichaudione H Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Disulfidptosis via Regulating NRF2‐SLC7A11 Signaling Pathway

Advanced Science, Volume 12, Issue 11, March 20, 2025.
Gaudichaudione H (GH) effectively activates NRF2 signaling and its target genes, such as SLC7A11, and pharmaceutical activation of NRF2‐SLC7A11 signaling pathway aggravates uptake of cysteine, disturbance of GSH synthesis, depletion of NADPH, and accumulation of disulfide molecules, ultimately leading to the formation of disulfide bonds between ...
Mengjiao Shi, Xinyan Li, Ying Guo, Yinggang Zhang, Jiayi Xu, Liangwen Yan, Rongrong Liu, Hong Wang, Shenkang Tang, Yaping Zhao, Zongfang Li, Yetong Feng, Dongmei Ren, Pengfei Liu   +13 more
wiley   +1 more source

Zinc is a transmembrane agonist that induces platelet activation in a tyrosine phosphorylation-dependent manner [PDF]

, 2015
Following platelet adhesion and primary activation at sites of vascular injury, secondary platelet activation is induced by soluble platelet agonists, such as ADP, ATP, thrombin and thromboxane.
Asselin, Ben R. Watson, Blake, Dominique Bihan, Emery, Faure, Forbes, Gibbins, Gibbins, Golden, Gordon, Gorodetsky, Heyns Adu, Jarvis, Jean-Daniel M. Malcor, Joanna-Marie Howes, Jung, Kehrel, Kirk A. Taylor, Knight, Konopatskaya, Mahdi, Marx, Marx, Milne, Morton, Nathan A. White, Nicholas Pugh, Onley, Pugh, Pugh, Raynal, Richard W. Farndale, Ruggeri, Sharir, Smethurst, Stadler, Stefanini, Stewart O. Sage, Trybulec, Vallee, Varga-Szabo, Xia, Zhang, Zufferey   +44 more
core   +1 more source