Results 121 to 130 of about 7,185 (234)
Journal of Cellular and Molecular Medicine, Volume 29, Issue 3, February 2025.ABSTRACT Iloprost, a prostacyclin (PGI2) analogue, stimulates the IP receptor (PTGIR) to interact with the Gsα β/γ complex, leading to the activation of adenylate cyclase, which enzyme produces the second messenger cAMP. Elevation in cAMP triggers intracellular signalling events and regulates a wide variety of cellular activities.
Xuexiang Wang +11 more
wiley +1 more source
PLoS ONE, 2011 Cdc42 and Rac1, members of the Rho family of small GTPases, play critical roles in actin cytoskeleton regulation. We have shown previously that Rac1 is involved in regulation of platelet secretion and aggregation. However, the role of Cdc42 in platelet activation remains controversial. This study was undertaken to better understand the role of Cdc42 in
Huzoor Akbar +7 more
openaire +5 more sources
Haemophilia, Volume 31, Issue 1, Page 140-147, January 2025.ABSTRACT Introduction Maintaining the balance between procoagulant and anticoagulant factors is essential for effective haemostasis. Emerging evidence suggests a modulation of bleeding tendency by factors in the anticoagulant and fibrinolytic systems. Aim This study investigates the clinical and laboratory characteristics of a family with combined von ...
Behnaz Pezeshkpoor +9 more
wiley +1 more source
Small but mighty: Platelets as multifunctional architects of tumor metastasis and immune regulation
MedComm – Future Medicine, Volume 3, Issue 4, December 2024.Platelets are crucial in cancer progression and immune response, impacting tumor metastasis and diagnosis while offering potential targets for antitumor therapies. Abstract Platelets play an irreplaceable role in hemostasis and wound healing. However, beyond these classical roles, as the smallest anucleate cells in the blood stream, they are crucial ...
Leyi Tang, Hubing Shi, Yong Luo
wiley +1 more source
Effect of Shear Stress on Platelet Activation via the Glycoprotein VI Receptor [PDF]
, 2002 Cardiovascular diseases are the nation\u27s leading cause of death. Such diseases are caused by platelet response to collagen especially in the event of vascular injury leading to thrombosis.
Chen, Hong M. +3 more
core +1 more source
The FEBS Journal, Volume 291, Issue 24, Page 5420-5434, December 2024.Intraplaque hemorrhages (IPH) result in hemolysis and liberation of iron‐containing heme and its oxidized metabolite, hemin. Hemin activates platelets and has strong prothrombotic activity. Here, we show that agonism of the atypical chemokine receptor 3 (ACKR3) inhibits hemin‐induced platelet activation.
Zoi Laspa +12 more
wiley +1 more source
Exacerbation of glycoprotein VI-dependent platelet responses in a rhesus monkey model of type 1 diabetes [PDF]
, 2018 Thrombosis is a life-threatening complication of diabetes. Platelet reactivity is crucial to thrombus formation, particularly in arterial vessels and in thrombotic complications causing myocardial infarction or ischaemic stroke, but diabetic patients ...
Andrews, Robert K +8 more
core +1 more source
Strategies to improve platelet cryopreservation: A narrative review
Transfusion, Volume 65, Issue 4, Page 740-749, April 2025.
Lauren Waters +2 more
wiley +1 more source
The effects of signal transducer and activator of transcription three mutations on human platelets
Platelets, 2018 Involvement of signal transducer and activator of transcription 3 (STAT3) in inflammation is well known. Recently, a role for STAT3 in platelet activation and platelet production has been suggested.
Floor E. Aleva +9 more
doaj +1 more source
TNF Receptor-Associated Factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets. [PDF]
, 2010 Background: Reactive oxygen species generation is one consequence of ligand engagement of platelet glycoprotein (GP) receptors GPIb-IX-V and GPVI, which bind VWF/collagen and initiate thrombosis at arterial shear, however the precise molecular mechanism ...
Andrews, R K +6 more
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