Results 61 to 70 of about 91,455 (273)

Engineering MnPt Bimetallic Nanozymes for Cascade Enzymatic Therapy and Enhanced Radio‐Immunotherapy

Advanced Science, EarlyView.
A CD44‐targeted MnPt bimetallic nanozyme (HD@MnO2) integrates multienzyme‐like activity with cGAS–STING activation to boost radio‐immunotherapy. Through cascade biocatalysis, it depletes glutathione, relieves hypoxia, and amplifies ROS, enhancing radiotherapy‐induced DNA damage and immunogenic cell death. The nanozyme promotes dendritic cell maturation
Wenyi Zhang, Yangyang Guo, Guoping Xu, Luhaoxiang Liu, Lin Chen, Cai Zhang, Yiming Li, Jianmin Li, Yang Zhao   +8 more
wiley   +1 more source

Aktivnost selenoenzima GPx-1 i GPx-3 u krvi radnih konja na teritoriji centralne Srbije

, 2022
Глутатион пероксидаза (GPx) је ензим који постоји у 8 изоензимских облика, од којих GPx-1 је облигаторни интрацелуларни ензим, док је GPx-3 активна у екстрацелуларним течностима, посебно у крвној плазми. Основна улога GPx се огледа у заштити ћелија од оксидативног стреса којег индукују слободни кисеонични радикали.
Valčić, Olivera, Milosavljević, Petar, Jovanović, Ivan B., Milanović, Svetlana   +3 more
openaire   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Glutathione peroxidase-1 primes pro-inflammatory cytokine production after LPS challenge in vivo. [PDF]

PLoS ONE, 2012
Reactive oxygen species produced during the innate immune response to LPS are important agents of anti-pathogen defence but may also cause oxidative lung damage.
Steven Bozinovski, Huei Jiunn Seow, Peter J Crack, Gary P Anderson, Ross Vlahos   +4 more
doaj   +1 more source

Going Forward and Back: The Complex Evolutionary History of the GPx

Biology, 2021
There is large diversity among glutathione peroxidase (GPx) enzymes regarding their function, structure, presence of the highly reactive selenocysteine (SeCys) residue, substrate usage, and reducing agent preference.
Thomaz Stumpf Trenz, Camila Luiza Delaix, Andreia Carina Turchetto-Zolet, Marcel Zamocky, Fernanda Lazzarotto, Márcia Margis-Pinheiro   +5 more
doaj   +1 more source

Association of GPX1 polymorphism, GPX activity and prostate cancer risk

Human & Experimental Toxicology, 2011
Prostate cancer is the second most common cancer in men worldwide. Although the aetiology of this disease remains largely unclear, several lines of evidence suggest that oxidative stress plays a role in prostate carcinogenesis. The antioxidant enzyme glutathione peroxidase 1 (GPX1) is part of the enzymatic antioxidant defence, preventing oxidative ...
Erdem, Onur, Eken, Ayse, Akay, Cemal, Arsova-Sarafinovska, Zorica, Matevska, Nadica, Suturkova, Ljubica, Erten, Koray, Ozgok, Yasar, Dimovski, Aleksandar, Sayal, Ahmet, Aydin, Ahmet   +10 more
openaire   +5 more sources

Pseudodifferential Weyl Calculus on (Pseudo-)Riemannian Manifolds

, 2020
One can argue that on flat space $\mathbb{R}^d$ the Weyl quantization is the most natural choice and that it has the best properties (e.g. symplectic covariance, real symbols correspond to Hermitian operators).
Dereziński, Jan, Latosiński, Adam, Siemssen, Daniel   +2 more
core   +1 more source

The Induction of Oxidative/Nitrosative Stress, Inflammation, and Apoptosis by a Ferric Carboxymaltose Copy Compared to Iron Sucrose in a Non-Clinical Model [PDF]

, 2015
Introduction: Ferric carboxymaltose is a next-generation polynuclear iron(III)-hydroxide carbohydrate complex for intravenous iron therapy belonging to the class of so-called non-biological complex drugs.
Angerosa, Margarita, Cao, Gabriel Fernando, Toblli, Jorge Eduardo   +2 more
core   +1 more source

Bifunctional Artificial Enzymes‐Loaded Microgels With LOX‐ and CAT‐Like Activities for Metabolic Reprogramming and Scarless Wound Repair

Advanced Science, EarlyView.
A bifunctional lactate oxidase‐like and catalase‐like artificial enzyme (Metazyme) is integrated into a rod‐shaped microgel (MetaRgel) to enable cascade lactate oxidation and oxygen regeneration. By reprogramming the wound metabolic microenvironment, MetaRgel alleviates excessive lactate accumulation, oxidative stress, hypoxia, and inflammation ...
Yongyuan Kang, Pai Peng, Liang Song, Qiaoxuan Wang, Zilong Zhong, Dongchao Qiu, Yunfan Liu, Kefei Zhao, Xiaofei Dong, Changyou Gao   +9 more
wiley   +1 more source

Response of Anti-Oxidative Stress Genes in Liver and Intestine in Broilers Fed Organic Acid and Silver Nanoparticles Coated on Zeolite in Starter Period [PDF]

پژوهشهای تولیدات دامی
Extended Abstract Background: The use of food supplements to improve growth, optimal production and increase feed efficiency in feeding livestock and poultry has become a common thing as a suitable solution in using feed as well as possible.
Fatemeh Asgharnezhad, Seyed Reza Hashemi, Saeed Hassani, Sharif Rostami   +3 more
doaj