Results 91 to 100 of about 29,098 (325)
m6A and m5C modification of GPX4 facilitates anticancer immunity via STING activation
Cell Death and Disease, 2023 Cancer immunotherapy is arguably the most rapidly advancing realm of cancer treatment. Glutathione peroxidase 4 (GPX4) has emerged as the vital enzyme to prevent lipid peroxidation and maintain cellular redox homeostasis.
Baoxiang Chen +9 more
doaj +1 more source
Sub-toxic Ethanol Exposure Modulates Gene Expression and Enzyme Activity of Antioxidant Systems to Provide Neuroprotection in Hippocampal HT22 Cells [PDF]
, 2016 Ethanol is known to cause severe systemic damage often explained as secondary to oxidative stress. Brain is particularly vulnerable to ethanol-induced reactive oxygen species (ROS) because the high amounts of lipids, and because nerve cell membranes ...
Casañas-Sánchez, Verónica +3 more
core +1 more source
USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma
Advanced Science, EarlyView.This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang +13 more
wiley +1 more source
Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies [PDF]
, 2008 Preeclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality. Preeclampsia may also predispose the fetus to increased risks of adult cardiovascular disease.
Broughton Pipkin, Fiona +4 more
core +2 more sources
Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation
Pain and TherapyPain, a complex symptom encompassing both sensory and emotional dimensions, constitutes a significant global public health issue. Oxidative stress is a pivotal factor in the complex pathophysiology of pain, with glutathione peroxidase 4 (GPX4) recognized as a crucial antioxidant enzyme involved in both antioxidant defense mechanisms and ferroptosis ...
Shiwen Fan +7 more
openaire +3 more sources
Advanced Science, EarlyView.The tumor‐associated macrophages (TAMs) in lung cancer tissues exhibit active cystine metabolism. Restricting cystine concentration in macrophages induces M1 phenotypic polarization and upregulation of PD‐L1 expression through the GSH‐NF‐κB signaling pathway.
Yun Xu +20 more
wiley +1 more source
Role of Mitochondria in Ferroptosis and Its Relationship to Tumors
Chinese Journal of Lung CancerFerroptosis is a recently discovered form of cell death that is distinct from apoptosis, characterized primarily by the accumulation of intracellular iron and increased levels of lipid peroxidation.
Zhanrui ZHANG, Hongyu LIU, Jun CHEN
doaj +1 more source
Redox Biology, 2021 The antioxidant function of the phospholipid hydroperoxide glutathione peroxidase (GPx4) is vital for the homeostasis of many cell types, from neoplastic cells to normal erythroid precursors.
Jeffrey M. Stolwijk +6 more
doaj
Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis
Nature CommunicationsS-palmitoylation is a reversible and widespread post-translational modification, but its role in the regulation of ferroptosis has been poorly understood. Here, we elucidate that GPX4, an essential regulator of ferroptosis, is reversibly palmitoylated on cysteine 66.
Bin Huang +10 more
openaire +3 more sources
Advanced Science, EarlyView.CRISPR/Cas9 screening reveals PTPN2 as essential for ALK+ ALCL survival. PTPN2 regulates TFRC to promote PINK1‐PRKN mitophagy. Oral PTPN2 inhibitor ABBV‐CLS‐484 disrupts mitochondrial renewal and blocks TFRC‐mediated mitophagy to exert anti‐tumor activities, supporting clinical development for ALK+ ALCL.
Wei‐Ting Wang +11 more
wiley +1 more source