Results 281 to 290 of about 29,098 (325)

PIK‐III‐Mediated Elevation of Thiamine Re‐Sensitises Renal Cell Carcinoma to Cuproptosis via Activating PDHA1

Cell Proliferation, EarlyView.
PIK‐III enhancing the efficacy of cuproptosis to kill renal cancer cells through dysregulating thiamine metabolism and dephosphorylation of pyruvate dehydrogenase complex E1 (PDHA1), providing a potential option for treatment of cuproptosis‐resistant renal cancer by the combination of PIK‐III and elesclomol.
Dongdong Xie, Yu Wang, Wenjie Cheng, Minbo Yan, Kunyu Li, Xiang Wu, Jiaqing Wu, Zhuangzhuang Zhang, Yingbo Dai   +8 more
wiley   +1 more source

Intersection of ferroptosis and nanomaterials brings benefits to breast cancer. [PDF]

Cell Biol Toxicol
Gao J, Ma N, Ni S, Han X.
europepmc   +1 more source

Overcoming BET‐inhibitor JQ1 resistance in aggressive non‐small cell lung cancer by inducing ferroptosis via inhibition of the BRD2–FTH1 axis

The FEBS Journal, EarlyView.
Recent studies emphasize alternative functions of FTH1 relevant for nuclear processes, such as transcriptional regulation. This study shows a novel FTH1/BRD2 association in non‐small cell lung carcinoma (NSCLC). This nuclear interaction affects BRD2 protein stability in aggressive NSCLC cells.
Stefania Scicchitano, Cinzia Garofalo, Beatrice Stella, Gianluca Santamaria, Flora Cozzolino, Vittoria Monaco, Flavia Biamonte, Maria Monti, Eleonora Vecchio, Maria Concetta Faniello   +9 more
wiley   +1 more source

METTL3/YTHDF3 m6A axis promotes ferroptosis in diabetic kidney disease by stabilizing TfR1

Journal of Diabetes Investigation, EarlyView.
METTL3/YTHDF3 m6A axis promoted ferroptosis in DKD by stabilizing TfR1, which could provide a reference for DKD treatment. ABSTRACT Objective Diabetic kidney disease (DKD) is a common complication of diabetes. N6‐Methyladenosine (m6A) modification is a widely studied epigenetic mechanism.
Jinmei Zhang, Xiaoping Zhou, Bin Wang, Yan Yin, Daihao Wei, Kun Li   +5 more
wiley   +1 more source

Targeting Ferroptosis in Tumors: Novel Marine-Derived Compounds as Regulators of Lipid Peroxidation and GPX4 Signaling. [PDF]

Mar Drugs
Wu Y, Chen X, Chen Z, Ma Y.
europepmc   +1 more source

Regulatory role of ATF2 in trophoblast ferroptosis via the PI3K/Akt/Nrf2 pathway in gestational diabetes mellitus

Journal of Diabetes Investigation, EarlyView.
ATF2 is highly expressed in GDM placental tissues and promotes ferroptosis in trophoblast cells by inhibiting the PI3K/Akt/Nrf2 pathway, thereby affecting trophoblast function and GDM progression. ABSTRACT Aims/Introduction To investigate the expression of ATF2 in GDM patients and its impact on trophoblast viability and ferroptosis, as well as to ...
Dandan Xia, Yuhui Zhang, Chenying Zhang, Huiyan Wang   +3 more
wiley   +1 more source

Nanomedicine initiates ferroptosis for enhanced lung cancer therapy. [PDF]

Drug Deliv
Xu Y, Zhang K, Ye Z, Huang Z, Chen R, Zhang Y, Zhang H, Kou L.   +7 more
europepmc   +1 more source

Nuclear binding SET domain 1 alleviates cartilage ferroptosis in knee osteoarthritis by upregulating the krüppel‐like factor 9/autophagy‐related 14 pathway via H3K36me2 modification

Journal of Cell Communication and Signaling, Volume 19, Issue 3, September 2025.
Abstract Knee osteoarthritis (KOA) is a progressive disease featured by cartilage damage. This study attempts to explore the role of nuclear binding SET domain 1 (NSD1) in KOA cartilage ferroptosis, thereby finding a new target for KOA treatment. Pathological changes, cartilage damage, and inflammatory cytokine levels in the established KOA mouse model
Qinglei Yang, Rugang Li, Zhiqiang Hu, Wengang Zhu, Hongying Yu   +4 more
wiley   +1 more source

The Crosstalk Between Ferritinophagy and Ferroptosis in Ischemic Stroke: Regulatory Mechanisms and Therapeutic Implications. [PDF]

Cell Mol Neurobiol
Shi Z, Chen K, Wang Y, Du H.
europepmc   +1 more source

A New Paradigm for Precision Drug Delivery in Inflammatory Bowel Disease: Effective Transfer, Enhanced Retention, and Pathology‐Targeting Treatment via Biomaterials and Engineered Platforms

MedComm – Biomaterials and Applications, Volume 4, Issue 3, September 2025.
This review presents a precision delivery paradigm for inflammatory bowel disease, centered on Effective Transfer, Enhanced Retention, and Pathology‐targeting Treatment. Biomaterials and engineered platforms facilitate effective intestinal transit, prolonged mucosal retention, and respond to pathological cues, such as oxidative stress or immune ...
Ruoyi Gan, Enqi Ni, Guanyue Li, Wei Chen
wiley   +1 more source