Results 331 to 340 of about 40,571 (376)

PUFA supplementation-dependent incorporation of ω-3 and ω-6 fatty acids into phospholipids and triglycerides in the intestinal epithelium of Gpx4⁺/⁻IEC mice on a Western diet

Rao, Zhigang, Meyer, Moritz, Grabherr, Felix, Adolph, Timon Erik, Koeberle, Andreas   +4 more
openalex   +1 more source

Lactate and H3K18 Lactylation Contribute To the Exacerbation of Acute Pancreatitis by Modulating NCOA4-mediated Ferroptosis. [PDF]

Inflammation
Han ZY, Ma XY, Ma SY, Shen ZJ, Lu ZH, Sun Y, Yu WL.   +6 more
europepmc   +1 more source

T-2 toxin és deoxinivalenol terhelés rövidtávú hatása a gpx4 gének expressziójára ponty fajban (Cyprinus carpio) [PDF]

, 2015
Balogh, Krisztián, Kovács, Balázs, Kövesi, Benjámin, Mézes, Miklós, Pelyhe, Csilla   +4 more
core  

Compound Sophorae Decoction Alleviates Ferroptosis in Colitis Rats via Activating Keap1/Nrf2/GPX4 Signaling Pathway. [PDF]

Gastroenterol Res Pract
Wang J, Chen Q, Chu S, Zhu F, Zhang L, Yi Z, Li J, Hu D, Fan H, Yu T.   +9 more
europepmc   +1 more source

Ferrocenyl ferroptosis inducers as an emerging class of anticancer agents: a mini review. [PDF]

RSC Med Chem
Klarek M, Gautam A, Kowalski K.
europepmc   +1 more source

Correction to "Calorie Restriction Protects against Contrast-Induced Nephropathy via SIRT1/GPX4 Activation". [PDF]

Oxid Med Cell Longev
europepmc   +1 more source

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Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke

Cell Death & Differentiation
Neuronal ferroptosis plays a key role in neurologic deficits post intracerebral hemorrhage (ICH). However, the endogenous regulation of rescuing ferroptotic neurons is largely unexplored. Here, we analyzed the integrated alteration of metabolomic landscape after ICH using LC-MS and MALDI-TOF/TOF MS, and demonstrated that aconitate decarboxylase 1 (Irg1)
Chao Wei, Z. Xiao, Yanling Zhang, Zhaoli Luo, Dongyang Liu, Liye Hu, Danmin Shen, Meng Liu, Lei Shi, Xiaotong Wang, Ting Lan, Qingqing Dai, Jing Liu, Wen Chen, Yurui Zhang, Qingyu Sun, Weihua Wu, Peipei Wang, Chenguang Zhang, Junchi Hu, Chu Wang, Fei Yang, Qian Li   +22 more
semanticscholar   +3 more sources

GPX4: old lessons, new features

Biochemical Society Transactions, 2022
GPX4 is a selenocysteine-containing protein that plays an essential role in repairing peroxidised phospholipids. Its role in organismal homeostasis has been known for decades, and it has been reported to play a pivotal role in cell survival and mammalian embryonic development.
Thamara, Nishida Xavier da Silva, José Pedro, Friedmann Angeli, Irina, Ingold   +2 more
openaire   +2 more sources

Small-molecule allosteric inhibitors of GPX4

Cell Chemical Biology, 2022
Encouraged by the dependence of drug-resistant, metastatic cancers on GPX4, we examined biophysical mechanisms of GPX4 inhibition, which revealed an unexpected allosteric site. We found that this site was involved in native regeneration of GPX4 under low glutathione conditions.
Hengrui Liu, Farhad Forouhar, Annie J. Lin, Qian Wang, Vasiliki Polychronidou, Rajesh Kumar Soni, Xin Xia, Brent R. Stockwell   +7 more
openaire   +2 more sources

SMG9 drives ferroptosis by directly inhibiting GPX4 degradation

Biochemical and Biophysical Research Communications, 2021
Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that plays an integral role in eliminating abnormal mRNA and corresponding proteins. It is unclear whether the NMD pathway is involved in regulating ferroptosis, which is a type of iron-dependent cell death mainly caused by the inhibition of the antioxidant SLC7A11-GPX4 axis.
Leng Han, Lulu Bai, Xue Fang, Jiao Liu, Rui Kang, Di Zhou, Daolin Tang, Enyong Dai   +7 more
openaire   +2 more sources