Results 341 to 350 of about 40,571 (376)

Gpx4 and Ferroptosis

2019
Glutathione peroxidase 4 (Gpx4) is a monomeric glutathione peroxidase with a unique ability to reduce hydroperoxide in complex lipids. Gpx4 is vital for development, and its function is also indispensable for many cell types of adult animal. Ferroptosis is an iron-dependent oxidative cell death. In ferroptosis, a high load of hydroperoxides in membrane
Qitao Ran, Paulina Mozolewska
openaire   +1 more source

STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation

Signal Transduction and Targeted Therapy
Despite advancements in interventional coronary reperfusion technologies following myocardial infarction, a notable portion of patients continue to experience elevated mortality rates as a result of myocardial ischemia-reperfusion (MI/R) injury.
Xiaohong Wang, Tao Chen, Sizhe Chen, Jie Zhang, Liangyu Cai, Changhao Liu, Yujie Zhang, Xiao Wu, Na Li, Zhiyong Ma, Lei Cao, Qian Li, Chenghu Guo, Qiming Deng, Wenqian Qi, Yonghao Hou, Ruiqing Ren, Wenhai Sui, Haonan Zheng, Yun Zhang, Meng Zhang, Cheng Zhang   +21 more
semanticscholar   +1 more source

Synchronously Evoking Disulfidptosis and Ferroptosis via Systematical Glucose Deprivation Targeting SLC7A11/GSH/GPX4 Antioxidant Axis.

ACS Nano
Disulfidptosis and ferroptosis are recently identified programmed cell deaths for tumor therapy, both of which highly depend on the intracellular cystine/cysteine transformation on the cystine transporter solute carrier family 7 member 11/glutathione ...
Mengsi Zhang, Hao Zheng, Xuanqi Zhu, Shuwei Liu, Hao Jin, Yang Chen, Lanlan Wan, Songling Zhang, Hao Zhang   +8 more
semanticscholar   +1 more source

Redox homeostasis maintained by GPX4 facilitates STING activation

Nature Immunology, 2020
Stimulator-of-interferon genes (STING) is vital for sensing cytosolic DNA and initiating innate immune responses against microbial infection and tumors. Redox homeostasis is the balance of oxidative and reducing reactions present in all living systems. Yet, how the intracellular redox state controls STING activation is unclear.
Mutian Jia, Danhui Qin, Chunyuan Zhao, Li Chai, Zhongxia Yu, Wenwen Wang, Li Tong, Lin Lv, Yuanyuan Wang, Jan Rehwinkel, Jinming Yu, Wei Zhao   +11 more
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Vitexin ameliorated diabetic nephropathy via suppressing GPX4-mediated ferroptosis

European Journal of Pharmacology, 2023
Diabetic nephropathy (DN) is common complication of diabetes. Ferroptosis is an atypical form of iron-dependent modulated necrosis and have been proven to contribute to the progress of diabetic nephropathy. Vitexin, a flavonoid monomer derived from medicinal plants that has various biological activities including anti-inflammatory and anticancer ...
Sheng Zhang, Shunxiao Zhang, Hua Wang, Yue Chen   +3 more
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Cyclophosphamide-induced GPX4 degradation triggers parthanatos by activating AIFM1

Biochemical and Biophysical Research Communications, 2022
Cyclophosphamide is an alkylating agent used to treat a variety of cancers, including leukemia. Here, we show a previously unrecognized role of cyclophosphamide in triggering the protein degradation of glutathione peroxidase 4 (GPX4), a phospholipid hydroperoxidase that protects cells from oxidative damage.
Liying Liu, Bingju Liu, Guotao Guan, Rui Kang, Yunpeng Dai, Daolin Tang   +5 more
openaire   +2 more sources

Research progress on GPX4 targeted compounds

European Journal of Medicinal Chemistry
Blocking the System Xc-_ GSH_GPX4 pathway to induce ferroptosis in tumor cells is a novel strategy for cancer treatment. GPX4 serves as the core of the System Xc-/GSH/GPX4 pathway and is a predominant target for inducing ferroptosis in tumor cells. This article summarizes compounds identified in current research that directly target the GPX4 protein ...
Bingru Li, Keguang Cheng, Tzumei Wang, Xing Peng, Ping Xu, Guoquan Liu, Dong Xue, Ning Jiao, Chao Wang   +8 more
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USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy

Proceedings of the National Academy of Sciences of the United States of America
Significance Ferroptosis is pivotal in various physiological and pathological processes, yet our understanding of its mechanisms and implications for tissue homeostasis and cancer immunotherapy remains incomplete.
Haiou Li, Yishuang Sun, Yingmeng Yao, Shanwen Ke, Nannan Zhang, Wenjun Xiong, Jie Shi, Chuan He, Xiangling Xiao, Haisheng Yu, Panpan Dai, Bolin Xiang, Xixin Xing, Gaoshan Xu, Wenjing Song, Jiquan Song, Jinfang Zhang   +16 more
semanticscholar   +1 more source

Targeting PLK1-CBX8-GPX4 axis overcomes BRAF/EGFR inhibitor resistance in BRAFV600E colorectal cancer via ferroptosis

Nature Communications
Metastatic BRAFV600E colorectal cancer (CRC) confers poor prognosis and represents a therapeutic bottleneck. To identify resistance mechanisms of the mitogen-activated protein kinase (MAPK) pathway in BRAFV600E CRC, we perform genome-wide CRISPR-Cas9 ...
Zhan Zhao, Jiashuai He, Shenghui Qiu, Lu Wang, Shuchen Huangfu, Yangzhi Hu, Qing Wu, Yabing Yang, Xiaobo Li, Maohua Huang, Shijin Liu, Hanyang Guan, Zuyang Chen, Xiangwei Zhang, Yiran Zhang, H. Ding, Xiaoxu Zhao, Guan Xiao, Yunlong Pan, Tongzheng Liu, Yanping Wu, Jinghua Pan   +21 more
semanticscholar   +1 more source

Gpx4 protects mitochondrial ATP generation against oxidative damage

Biochemical and Biophysical Research Communications, 2007
Mitochondrial ATP production can be impaired by oxidative stress. Glutathione peroxidase 4 (Gpx4) is an antioxidant defense enzyme found in mitochondria as well as other subcellular organelles that directly detoxifies membrane lipid hydroperoxides. To determine if Gpx4 protects ATP production in vivo, we compared mitochondrial ATP production between ...
Hanyu, Liang, Holly, Van Remmen, Victoria, Frohlich, James, Lechleiter, Arlan, Richardson, Qitao, Ran   +5 more
openaire   +2 more sources