Results 351 to 360 of about 40,571 (376)

Targeting GPX4 palmitoylation to boost antitumor immunity

Trends in Cancer
Despite significant milestones in cancer immunotherapy, tumor cells often escape immune surveillance. Zhou et al. revealed that the pivotal ferroptosis suppressor glutathione peroxidase 4 (GPX4) can undergo palmitoylation by zDHHC8, enhancing ferroptosis resistance.
Daehee Hwang, Whitney S. Henry
openaire   +2 more sources

Emerging Therapeutic Strategies Targeting GPX4-Mediated Ferroptosis in Head and Neck Cancer

International Journal of Molecular Sciences
Ferroptosis, a regulated form of iron-dependent lipid peroxidation-induced cell death, has emerged as a compelling therapeutic strategy to overcome treatment resistance in head and neck cancer (HNC).
Jaewang Lee, Youngin Seo, Jong-Lyel Roh
semanticscholar   +1 more source

A prospective therapeutic strategy: GPX4-targeted ferroptosis mediators

European Journal of Medicinal Chemistry
As a crucial regulator of oxidative homeostasis, seleno-protein glutathione peroxidase 4 (GPX4) represents the primary defense system against ferroptosis, making it a promising target with important clinical application prospects. From the discovery of covalent and allosteric sites in GPX4, substantial advancements in GPX4-targeted small molecules have
Jia-Yu Qian, Chao-Yuan Lou, Yi-Li Chen, Lie-Feng Ma, Wei Hou, Zha-Jun Zhan   +5 more
openaire   +2 more sources

Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2/GPx4 Pathway.

Journal of Agricultural and Food Chemistry
Lipid peroxidation (LP) leads to changes in the fluidity and permeability of cell membranes, affecting normal cellular function and potentially triggering apoptosis or necrosis. This process is closely correlated with the onset of many diseases. Evidence
Mengmeng Zhang, Jingbo Liu, Yiding Yu, X. Liu, Xiaomin Shang, Zhiyang Du, Menglei Xu, Ting Zhang   +7 more
semanticscholar   +1 more source

DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis

Bone Research
Osteoporosis (OP) is a common and fracture-prone skeletal disease characterized by deteriorated trabecular microstructure and pathologically involving various forms of regulated bone cell death.
Binjia Ruan, Jian Dong, Fanhao Wei, Zhiqiang Huang, Bin Yang, Lijun Zhang, Chuling Li, Hui Dong, Wangsen Cao, Hongwei Wang, Yongxiang Wang   +10 more
semanticscholar   +1 more source

BRCA1-mediated dual regulation of ferroptosis exposes a vulnerability to GPX4 and PARP co-inhibition in BRCA1-deficient cancers.

Cancer Discovery
Resistance to poly (ADP-ribose) polymerase inhibitors (PARPi) limits the therapeutic efficacy of PARP inhibition in treating breast cancer susceptibility gene 1 (BRCA1)-deficient cancers.
Guang Lei, Chao Mao, Amber Horbath, Yuelong Yan, Shirong Cai, Jun Yao, Yan Jiang, Mingchuang Sun, Xiaoguang Liu, Jun Cheng, Zhihao Xu, Hyemin Lee, Qidong Li, Zhengze Lu, Zhuang Li, Mei-Kuang Chen, Anagha Alapati, T. Yap, Mien-Chie Hung, M. J. You, H. Piwnica-Worms, Boyi Gan   +21 more
semanticscholar   +1 more source

GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment.

Biochimica et biophysica acta. Reviews on cancer, 2023
Yi Liu, Y. Wan, Jiang Yi, Lin Zhang, Wenjun Cheng   +4 more
semanticscholar   +1 more source

Istraživanje feroptoznog inhibitora GPx4

2015
Istraživanje feroptoznog inhibitora ...
openaire   +1 more source

Unraveling Masked GPX4 Inhibitors

Synfacts, 2020
openaire   +1 more source

Selective Small-Molecule Activator of Patient-Derived GPX4 Variant

ACS Chemical Biology
Glutathione peroxidase 4 (GPX4) is distinguished from other members of the GPX family as being the enzyme capable of reducing phospholipid hydroperoxides within cellular membranes and therefore protecting cells from ferroptosis, a form of iron-driven cell death involving lipid peroxidation.
Hengrui Liu, Farhad Forouhar, Russell Saneto, Brent R. Stockwell   +3 more
openaire   +2 more sources