Results 361 to 370 of about 40,571 (376)

Mouse Models for Glutathione Peroxidase 4 (GPx4)

2011
The selenoperoxidase glutathione peroxidase 4 (GPx4 – also frequently referred to as phospholipid hydroperoxide glutathione peroxidase, PHGPx) is one of the eight glutathione peroxidases in mammals, but the only one known to be essential for early mouse development.
openaire   +2 more sources

Mitochondria-specific GPX4 inhibition enhances ferroptosis and antitumor immunity

Journal of Controlled Release
Ferroptosis is gaining attention as a potential cancer immunotherapy strategy, as it can stimulate antitumor responses by enhancing dendritic cell (DC) activation and the infiltration of cytotoxic T cells (CTLs). However, cancer cells often develop resistance to ferroptosis, reducing the effectiveness of existing treatments.
Jian, Xiao, Nana, Feng, Qiushi, Li, Xianghui, Cao, Qingqing, Huang, Biyu, Zhou, Zhenrui, Fan, Liping, Wei, Yang, Liu   +8 more
openaire   +2 more sources

GPx4

2018
Matilde Maiorino, Antonella Roveri, Fulvio Ursini   +2 more
openaire   +1 more source

Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity

Nature Cancer
Liang Zhou, Guangyu Lian, Tao Zhou, Zhe Cai, Shuai Yang, Weining Li, Lilin Cheng, Ying Ye, Mingfeng He, Jianru Lu, Qifeng Deng, Bihui Huang, Xiaoqian Zhou, Desheng Lu, Feng Zhi, Jun Cui   +15 more
semanticscholar   +1 more source

PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer

Nature Cell Biology
Yizeng Fan, Yuzhao Wang, Weichao Dan, Yilei Zhang, L. Nie, Zhiqiang Ma, Yanxin Zhuang, Bo Liu, Mengxing Li, Tianjie Liu, Zixi Wang, Leihong Ye, Yinghong Wei, Yuzeshi Lei, Chendong Guo, Jiale An, Chi Wang, Yulin Zhang, Jin Zeng, Wenyi Wei, Boyi Gan, Lei Li   +21 more
semanticscholar   +1 more source

Interfering with GPX4 degradation

Nature Chemical Biology
Jing Li, Yuhan Zhou, Weimin Wang
openaire   +2 more sources

Protein kinase A regulates ferroptosis by controlling GPX4 m6A modification through phosphorylation of ALKBH5

Cell Death and Differentiation
Xiaocheng Zhao, Yanxi Sun, Juan Zou, Yanxia Wu, Minyi Huang, Huimin Kong, Guangda Liu, Holger Gerhardt, Wei Gu, Yunjiao Zhang, M. Shang, Xingwu Wang   +11 more
semanticscholar   +1 more source

PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation

Nature Chemical Biology
Peixiang Zheng, Zhiqiang Hu, Yuling Shen, Lina Gu, Ouyang Yuan, Yuran Duan, Guimei Ji, Bofei Dong, Yanni Lin, T. Wen, Qi Tian, Yueru Hou, Qimin Zhou, Xue Sun, Xiaohan Chen, Katherine L Wang, Shudi Luo, Shiqi Wu, Yuening Sun, Min Li, Liwei Xiao, Qingang Wu, Ying Meng, Guijun Liu, Zheng Wang, X. Bai, Shengzhong Duan, Yuan Ding, Yanli Bi, Yuhao Wang, Gaopeng Li, Xiaoguang Liu, Zhimin Lu, Xiaohong Wu, Zhiyuan Tang, Daqian Xu   +35 more
semanticscholar   +1 more source

Glutathion Peroxidase 4 (Gpx4)

2015
openaire   +1 more source

GPX4 methylation puts a brake on ferroptosis

Nature Cell Biology
Graeme I. Lancaster, Andrew J. Murphy
openaire   +2 more sources