Results 41 to 50 of about 5,253 (50)

Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2/GPx4 Pathway.

Journal of Agricultural and Food Chemistry
Lipid peroxidation (LP) leads to changes in the fluidity and permeability of cell membranes, affecting normal cellular function and potentially triggering apoptosis or necrosis. This process is closely correlated with the onset of many diseases. Evidence
Mengmeng Zhang, Jingbo Liu, Yiding Yu, X. Liu, Xiaomin Shang, Zhiyang Du, Menglei Xu, Ting Zhang   +7 more
semanticscholar   +1 more source

GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment.

Biochimica et biophysica acta. Reviews on cancer, 2023
Yi Liu, Y. Wan, Jiang Yi, Lin Zhang, Wenjun Cheng   +4 more
semanticscholar   +1 more source

Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function

Nature Cell Biology, 2023
Ke Wu, Meisi Yan, Tong Liu, Zhenghai Wang, Yuran Duan, Yan Xia, Guimei Ji, Yuling Shen, Lei Wang, Lin Li, Peixiang Zheng, Bofei Dong, Qingang Wu, Liwei Xiao, Xueying Yang, H.-M. Shen, T. Wen, Jingjing Zhang, Jinfeng Yi, Yuhan Deng, Xu Qian, Leina Ma, Jing Fang, Qingxin Zhou, Zhimin Lu, Daqian Xu   +25 more
semanticscholar   +1 more source

Ferrostatin‐1 inhibits ferroptosis of vascular smooth muscle cells and alleviates abdominal aortic aneurysm formation through activating the SLC7A11/GPX4 axis

The FASEB Journal
Ferroptosis, a type of iron‐catalyzed necrosis, is responsible for vascular smooth muscle cell (VSMC) death and serves as a potential therapeutic target for alleviating aortic aneurysm.
Xin He, Yunchuan Xiong, Yu Liu, Yaozhen Li, Haiyang Zhou, Keming Wu   +5 more
semanticscholar   +1 more source

Baicalin induces ferroptosis in osteosarcomas through a novel Nrf2/xCT/GPX4 regulatory axis.

Phytomedicine, 2023
Rui-Jia Wen, Xin Dong, H. Zhuang, Feng-Xiang Pang, Shouchang Ding, Nan Li, Yong-xin Mai, Shufang Zhou, Jun-Yan Wang, Jin-fang Zhang   +9 more
semanticscholar   +1 more source

Polyphyllin I induced ferroptosis to suppress the progression of hepatocellular carcinoma through activation of the mitochondrial dysfunction via Nrf2/HO-1/GPX4 axis.

Phytomedicine, 2023
Renyi Yang, Wen-hui Gao, Zhibing Wang, Huiying Jian, Lian Peng, Xiaopeng Yu, Peisen Xue, Wei Peng, Kexiong Li, Puhua Zeng   +9 more
semanticscholar   +1 more source

Rhein attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through NRF2/SLC7A11/GPX4 pathway

Experimental Neurology, 2023
Hua Liu, Tian-ai Zhang, Wenyue Zhang, Si-Rui Huang, Yue Hu, Jia Sun   +5 more
semanticscholar   +1 more source

Targeting GPX4 in ferroptosis and cancer: chemical strategies and challenges.

TIPS - Trends in Pharmacological Sciences
Jiao Liu, D. Tang, Rui Kang
semanticscholar   +1 more source

Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis.

Acta Pharmacologica Sinica
Jian-qin Lai, Le-le Zhao, Chao Hong, Qiu-ming Zou, Jin-Xuan Su, Si-jia Li, Xiao-feng Zhou, Zi-Sheng Li, Bo Deng, Jie Cao, Qi Qi   +10 more
semanticscholar   +1 more source

Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke.

Cell Death and Differentiation
Chao Wei, Z. Xiao, Yanling Zhang, Zhao Luo, Dongyang Liu, Liye Hu, Danmin Shen, Meng Liu, Lei Shi, Xiaotong Wang, Ting Lan, Qingqing Dai, Jing Liu, Wen Chen, Yurui Zhang, Qingyu Sun, Wei-Ching Wu, Peipei Wang, Chenguang Zhang, Junchi Hu, Chu Wang, Fei Yang, Qian Li   +22 more
semanticscholar   +1 more source