Results 41 to 50 of about 40,571 (376)

Ferroptosis resistance mediated by exosomal release of iron

Molecular & Cellular Oncology, 2020
Understanding how cells resist ferroptosis is necessary for exploiting this iron-dependent mode of cell death for the treatment of cancer and other diseases.
Caitlin W. Brown, Arthur M. Mercurio
doaj   +1 more source

Protective role of glutathione peroxidase 4 in laser-induced choroidal neovascularization in mice. [PDF]

PLoS ONE, 2014
PURPOSE: To evaluate the influence of glutathione peroxidase 4 (GPx4) expression in retinal pigment epithelium (RPE)/choroid tissue using a mouse model of laser-induced choroidal neovascularization (CNV).
Murilo Felix Roggia, Hirotaka Imai, Tomoyasu Shiraya, Yasuo Noda, Takashi Ueta   +4 more
doaj   +1 more source

Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer

Cell Death and Differentiation, 2022
The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in gastric cancer (GC). The dysregulation of the Wnt/beta-catenin signaling pathway is critically associated with GC development and chemotherapy resistance ...
Yue Wang, Lixin Zheng, Wenjing Shang, Zongchen Yang, Tongyu Li, Fen Liu, Weimin Shao, Lin Lv, Li Chai, L. Qu, Qing Xu, J. Du, Xiuming Liang, Jiping Zeng, J. Jia   +14 more
semanticscholar   +1 more source

Selenium and GPX4, a vital symbiosis

Free Radical Biology and Medicine, 2018
Selenium has transitioned from an environmental poison and carcinogen to an essential micronutrient associated with a broad array of health promoting effects. These beneficial effects are now accepted to be linked to its incorporation into selenoproteins, a family of rare proteins utilizing a specialized translation machinery to integrate selenium in ...
Friedmann Angeli, J.P.F., Conrad, M.
openaire   +4 more sources

Selenium and vascular health [PDF]

, 2011
Peer reviewedPublisher ...
Sneddon, Alan A.
core   +1 more source

The E3 ligase TRIM26 suppresses ferroptosis through catalyzing K63-linked ubiquitination of GPX4 in glioma

Cell Death and Disease, 2023
The selenium-containing enzyme GPX4 moonlights as a central regulator of ferroptosis, an iron-dependent, nonapoptotic form of regulated cell death caused by lipid peroxidation.
Zhangjie Wang, Yuan Xia, Yang Wang, Ruiqiu Zhu, Hongbo Li, Yu Liu, Na Shen   +6 more
doaj   +1 more source

Monitoring and Regulating Intracellular GPX4 mRNA Using Gold Nanoflare Probes and Enhancing Erastin-Induced Ferroptosis

Biosensors, 2022
Glutathione peroxidase 4 (GPX4) plays an important effect on ferroptosis. Down-regulating the expression of GPX4 mRNA can decrease the content of GPX4. In this work, a gold nanoflare (AuNF) probe loaded with anti-sense sequences targeting for GPX4 mRNA ...
Xiaoyan Liu, Qiangqiang Yang, Yanan Sui, Qiaoli Yue, Shuqing Yan, Chuan Li, Min Hong   +6 more
doaj   +1 more source

Selenoprotein gene nomenclature [PDF]

, 2016
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis.
Arn\ue9r, Elias S., Berry, Marla J., Bruford, Elspeth A., Burk, Raymond F., Carlson, Bradley A., Castellano, Sergi, Chavatte, Laurent, Conrad, Marcus, Copeland, Paul R., Diamond, Alan M., Driscoll, Donna M., Ferreiro, Ana, Floh\ue9, Leopold, Gladyshev, Vadim N, Green, Fiona R., Guig\uf3, Roderic, Handy, Diane E., Hatfield, Dolph L., Hesketh, John, Hoffmann, Peter R., Holmgren, Arne, Hondal, Robert J., Howard, Michael T., Huang, Kaixun, K\uf6hrle, Josef, Kim, Hwa Young, Kim, Ick Young, Krol, Alain, Kryukov, Gregory V., Lee, Byeong Jae, Lee, Byung Cheon, Lei, Xin Gen, Lescure, Alain, Liu, Qiong, Lobanov, Alexei V., Loscalzo, Joseph, Maiorino, Matilde, Mariotti, Marco, Prabhu, K. Sandeep, Rayman, Margaret P., Regina, Brigelius Floh\ue9, Rozovsky, Sharon, Salinas, Gustavo, Schmidt, Edward E., Schomburg, Lutz, Schweizer, Ulrich, Simonovi\u107, Miljan, Sunde, Roger A., Tsuji, Petra A., Tweedie, Susan, Ursini, Fulvio, Whanger, Philip D., Zhang, Yan   +52 more
core   +3 more sources

Rat liver antioxidant response to iron and copper overloads [PDF]

, 2014
The rat liver antioxidant response to Fe and Cu overloads (0–60 mg/kg) was studied. Dose- and time-responses were determined and summarized by t1/2 and C50, the time and the liver metal content for half maximal oxidative responses.
Boveris, Alberto Antonio, Castro-Parodi, Mauricio Omar, Damiano, Alicia Ermelinda, Ferrarotti, Nidia Fatima, Musacco Sebio, Rosario Natalia, Repetto, Marisa Gabriela, Saporito Magriñá, Christian Martín, Semprine, Jimena Vanina, Torti, Horacio Emilio   +8 more
core   +1 more source

Association between GPX4 and HMGCR gene expression and cell proliferation in atypical hyperplasia of the breast [PDF]

Exploration of Medicine
Aim: Using a dataset available from the NCBI Gene Expression Omnibus Repository, this in silico study investigated the differential expression of GPX4, the gene coding for the detoxifying enzyme glutathione peroxidase paired samples of AH (atypical ...
Danila Coradini
doaj   +1 more source