Results 91 to 100 of about 90,989 (277)
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Valuative and geometric characterizations of Cox sheaves
, 2013 We give an intrinsic characterization of Cox sheaves on Krull schemes in terms of their valuative algebraic properties. We also provide a geometric characterization of their graded relative spectra in terms of good quotients of graded schemes, extending ...
Bechtold, Benjamin
core
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
The Category
MathematicsIn this work, we use the concept of G-weak graded rings and G-weak graded modules, which are based on grading by a set G of left coset representatives for the left action of a subgroup H of a finite X on X, to define the conjugation action of the set G ...
Rahmah Al-Omari, Mohammed Al-Shomrani
doaj +1 more source
Journal of Pure and Applied Algebra, 1985 Generalized Rees rings were introduced by F. van Oystaeyen as a particular case of graded Dedekind rings. The author uses this class of rings for the study of the graded module category and the graded class group of a graded Dedekind ring. Since the theory of graded Dedekind rings is not completely parallel to the ungraded case, the author derives some
openaire +2 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Derived equivalences of upper-triangular ring spectra via lax limits
Comptes Rendus. MathématiqueWe extend a theorem of Ladkani concerning derived equivalences between upper-triangular matrix rings to ring spectra. Our result also extends an analogous theorem of Maycock for differential graded algebras.
Jasso, Gustavo
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source