Results 231 to 240 of about 4,936,870 (299)

Antimicrobial-laden PerOssal beads display in vitro inhibition and killing of extensively drug-resistant Gram-negative bacteria associated with conflict wounds in Ukraine. [PDF]

Bone Joint Res
Claireaux HA, Douglas EJA, Pallett SJC, Moore LSP, O'Shea MK, Moshynets OV, Jones JR, Ramasamy A, Edwards AM.   +8 more
europepmc   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

Breaking the outer membrane barrier: structure, targets, and antimicrobial strategies for Gram-negative bacteria. [PDF]

Front Microbiol
Xu F, Xie Y, Yu W, Wang Z.
europepmc   +1 more source

Assembly of Bioactive Superstructures via Metal–Phenolic Complexation for Blood Purification

Angewandte Chemie, EarlyView.
Bioactive superstructures are assembled via metal–phenolic‐mediated assembly on agarose templates, followed by modification with human serum albumin. These superstructures demonstrate high bilirubin adsorption efficiency, strong antibacterial activity, and anticoagulant activity, providing a strategy for the rational design of multifunctional blood ...
Po Wang, Jingqu Chen, Siying Chen, Binsha Peng, Zhifeng Zhou, Ling Zhang, Rui Xie, Xiaojie Ju, Wei Wang, Dawei Pan, Liangyin Chu, Frank Caruso, Zhuang Liu   +12 more
wiley   +1 more source

Bacteriological profile and multidrug resistance of Gram-negative bacteria in wound infections at a secondary healthcare facility in Ghana. [PDF]

BMC Microbiol
Agborgbor A, Abubakar L, Agyei H, Lassey G, Acheampong A, Kudzordzi PC, Nyarko P, Otabil KB.   +7 more
europepmc   +1 more source

Structural and Functional Siderophore Remodeling by Enzymatic Delipidation

Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.
A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Elena Herzog, Keishi Ishida, Evelyn M. Molloy, Ron Hermenau, Kirstin Scherlach, Christian Hertweck   +5 more
wiley   +1 more source

Prophage Activation Triggers Extracellular Synthesis of DNA in Bacterial Biofilms via Rolling Circle Replication

Angewandte Chemie, EarlyView.
Shewanella oneidensis and Bacillus subtilis, both harboring prophages, reveal a novel biosynthetic route to scalable and programmable DNA superstructures in flower‐ and wire‐like shapes, respectively. Activation of prophages is achieved via 3‐hour starvation and monitored using reporter strains.
Gabriel Antonio S. Minero, Line Mørkholt Lund, Lasse Hyldgaard Klausen, Obinna Markraphael Ajunwa, Mingdong Dong, Rikke Louise Meyer, Victoria Birkedal, Kai Thormann   +7 more
wiley   +1 more source

Organosulfur scaffolds as quorum sensing and biofilm modulators in Gram-negative bacteria. [PDF]

FEMS Microbiol Rev
Nwobodo DC, Egbujor MC, Kiprotich S, Meijler MM.   +3 more
europepmc   +1 more source

Characterization of gepotidacin activity, including <i>in vitro</i> kill kinetics, checkerboard, and PAE/SME testing against gram-positive and gram-negative bacteria. [PDF]

Microbiol Spectr
Arends SJR, West J, Scangarella-Oman NE, Castanheira M, Mendes RE.   +4 more
europepmc   +1 more source

Chelate-conjugated β-lactams resensitize metallo-β-lactamase IMP-1-producing gram-negative bacteria against carbapenem antibiotics. [PDF]

Microbiol Spectr
Toyomoto T, Ono K, Honda H, Zhang T, Tsutsuki H, Uegama A, Fukushima R, Yamamoto K, Tanaka Y, Nakburee K, Kaewkong W, Tsugawa H, Sawa T.   +12 more
europepmc   +1 more source