Results 181 to 190 of about 278,994 (250)

Multi‐omics biomarkers for intestinal infection and inflammation in inflammatory bowel disease: Current evidence, translational challenges, and diagnostic opportunities

Interdisciplinary Medicine, EarlyView.
Prospective multi‐site cohorts, multi‐omics profiling, and computational analysis may help identify biomarker patterns across clinical settings in IBD and superimposed infections. With further mechanistic and clinical validation, these signals could support the development of practical multi‐analyte tools for more precise diagnosis and management ...
Ziyu Yang, Jiayi Yao, Xinxian Zhao, Yan Xu, Yifan Chen, Tianchi Chen, Ying Jian, Min Li   +7 more
wiley   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

A Longitudinal Study of Antimicrobial Resistance in Oral Bacterial Isolates From Periodontitis Patients in Taiwan. [PDF]

Int Dent J
Kung JC, Lai CH, Chen PH, Lan TH, Shih CJ, Yan DY, Kao LT, Yang WT, Tseng BS, Yang TY.   +9 more
europepmc   +1 more source

Advanced Molecular Imaging Probes for Skeletal Diseases: Current Progress and Future Perspectives

iRADIOLOGY, EarlyView.
This review summarizes the potential molecular imaging techniques and probes for common orthopedic diseases, such as trauma, infection, metabolism, tumor, joint, spine and other fields, aiming to provide a basis for the development of a new generation of molecular imaging probes.
Shuo Guo, Yuling Cui, Zhiye Fan, Chenxin Jiang, Bowen Fu, Guangbin Cui, Yanli He   +6 more
wiley   +1 more source

Performance of the LIAISON PLEX gram-negative blood culture assay for identifying bacterial pathogens and resistance genes in blood cultures. [PDF]

J Clin Microbiol
Dhiman N, Emery CL, Chow S-K, Ho D, Granato P, Bernier B, Farhang J.   +6 more
europepmc   +1 more source

TREATMENT OF GRAM POSITIVE BACTERIAL INFECTIONS WITH NEW ANTIBIOTIC ENDURACIDIN

CHEMOTHERAPY, 1968
DONOMAE, IMASATO, TACHIBANA, TERUO, AKITA, YOSHIYA, ARATAKE, KAZUHIKO, TAKAOKA, AIMEI, INOUE, HIKOHACHIRO, MISE, TORU, MIYAGAWA, MITSUO, TAKAHASHI, KOJI   +8 more
openaire   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

Microbiological Profile and Antimicrobial Resistance Patterns in an Intensive Care Unit: Emphasis on ESKAPE Pathogens. [PDF]

Antibiotics (Basel)
Souza LA, Souza LA, Bilizario Noguerol Andrade JC, Del Fiol FS.   +3 more
europepmc   +1 more source

Duplex Recombinase Polymerase Amplification‐Lateral Flow Assay for Rapid Visual Detection of Critical Antibiotic Resistance Genes in Escherichia coli and Klebsiella pneumoniae From Positive Blood Cultures

Journal of Clinical Laboratory Analysis, EarlyView.
This study developed a pair of duplex RPA‐LFA assays for the simultaneous detection of critical resistance genes, blaCTX‐M/mcr‐1 and blaoxa‐48‐like/blaNDM, from hemoculture samples. Under optimized conditions, duplex RPA was performed at 37°C–38°C for 25 min, followed by LFA for 10–15 min.
Variya Nemidkanam, Pattamaporn Deechart, Nuntaree Chaichanawongsaroj   +2 more
wiley   +1 more source

Caballeronia Bacteremia in Children with Cancer, United States. [PDF]

Emerg Infect Dis
Glasgow HL, Federico SM, Ribiero RC, Adderson EE.   +3 more
europepmc   +1 more source