Results 31 to 40 of about 3,331 (249)

Novel Antibiotics for the Treatment of Gram-Positive Bacterial Infections

Journal of Medicinal Chemistry, 2002
The natural dipeptide antibiotic TAN 1057 A,B displays excellent antibacterial activity against staphylococci including methicillin resistant Staphylococcus aureus. However, the in vitro activity against additional Gram-positive strains, in particular pneumococci and Enterococcus faecalis, proved to be considerably lower.
Brands, M., Endermann, R., Gahlmann, R., Kruger, J., Raddatz, S., Stoltefuss, J., Belov, Vladimir N., Nizamov, S., Sokolov, Viktor V., Meijere, Armin de   +9 more
openaire   +3 more sources

Biofilm-Related Infections in Gram-Positive Bacteria and the Potential Role of the Long-Acting Agent Dalbavancin

Frontiers in Microbiology, 2021
Infections caused by Gram-positive bacteria are a major public health problem due to their increasing resistance to antibiotics. Staphylococcus and Enterococcus species’ resistance and pathogenicity are enhanced by their ability to form biofilm.
Alessandra Oliva, Stefania Stefani, Mario Venditti, Enea Gino Di Domenico   +3 more
doaj   +1 more source

Prevalence and Antibiotic Resistance Pattern of Gram-Positive Isolates from Burn Patients in Velayat Burn Center in Rasht, North of Iran

Medical Laboratory Journal, 2021
Background and objectives: Bacterial contamination of wounds is a serious problem, particularly in burn patients. Gram-positive bacteria are the predominant cause of infection in newly hospitalized burn cases.
Mobina Hosseini, Meysam Hasannejad-Bibalan, Tofigh Yaghoubi, Mohammadreza Mobayen, Parisa Khoshdoz, Sara Khoshdoz, Niloofar Faraji, Hadi Sedigh Ebrahim-Saraie   +7 more
doaj  

BACTERIAL PATTERN AMONG SEPSIS PATIENTS IN INTERNAL MEDICINE INPATIENT WARD DR. SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA

Majalah Biomorfologi, 2022
Highlights: 1. Bacteria remain a major cause of bacterial sepsis. 2. The most common causal agent in bacterial septicaemia was the gram-positive bacterium. Abstract: Background: Bacteria remain the primary cause of bacterial sepsis.
Ilma Dzurriyyatan Toyyibah, Musofa Rusli, Juniastuti Juniastuti   +2 more
doaj   +1 more source

Bactericidal/Permeability-Increasing Protein Is an Enhancer of Bacterial Lipoprotein Recognition

Frontiers in Immunology, 2018
Adequate perception of immunologically important pathogen-associated molecular patterns like lipopolysaccharide and bacterial lipoproteins is essential for efficient innate and adaptive immune responses.
Sigrid Bülow, Lisa Zeller, Maren Werner, Martina Toelge, Jonas Holzinger, Clemens Entzian, Thomas Schubert, Franziska Waldow, Nicolas Gisch, Sven Hammerschmidt, André Gessner   +10 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Prevalence and Antimicrobial Susceptibility Patterns of Bacterial Pathogens in Urinary Tract Infections in University Hospital of Campania “Luigi Vanvitelli” between 2017 and 2018

Antibiotics, 2020
Urinary tract infections (UTIs) are the most common and expensive health problem globally. The treatment of UTIs is difficult owing to the onset of antibiotic-resistant bacterial strains.
Veronica Folliero, Pina Caputo, Maria Teresa Della Rocca, Annalisa Chianese, Marilena Galdiero, Maria R. Iovene, Cameron Hay, Gianluigi Franci, Massimiliano Galdiero   +8 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Dynamic Profiling of Lipoteichoic Acid (LTA) and/or Lipopolysaccharide (LPS) Positive Extracellular Vesicles in Plasma as Diagnostic and Prognostic Biomarkers for Bacterial Infection

Advanced Science
Bacterial extracellular vesicles (EVs) are emerging as promising biomarkers for diagnosing bacterial infections. This study explores the diagnostic potential of plasma EVs carrying bacterial lipopolysaccharide (LPS) or lipoteichoic acid (LTA).
Qianqian Gao, Wenwu Zhou, Nadira Nurxat, Ke Xu, Yunyun Xu, Wei Li, Tianchi Chen, Cong Hu, Liang Dong, Qian Liu, Min Li   +10 more
doaj   +1 more source