Results 111 to 120 of about 102,001 (282)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

The global B − L symmetry in the flavor-unified SU(N) theories

Journal of High Energy Physics
We study the origin of the global B − L symmetry in a class of flavor-unified theories with gauge groups of SU(N ≥ 6). In particular, we focus on the SU(8) theory which can minimally embed three-generational SM fermions non-trivially.
Ning Chen, Ying-nan Mao, Zhaolong Teng
doaj   +1 more source

Towards Grand Unification

Sidharth had shown that gravitation can be reconciled with electromagnetic and other forces if we start from a Landau-Ginzburg phase transition. This is further remarked upon and a unification of all forces of nature is proposed.Comment: 10 pages, IIAMIS-
Sidharth, Burra G.
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

The Standard Model quark/lepton masses and the Cabibbo-Kobayashi-Maskawa mixing in an SU(8) theory

Journal of High Energy Physics
The observed Standard Model (SM) quark/lepton mass hierarchies and the Cabibbo-Kobayashi-Maskawa (CKM) mixing pattern are described in an SU(8) theory through its realistic symmetry breaking pattern with three intermediate stages, which rely on a set of ...
Ning Chen, Ying-nan Mao, Zhaolong Teng
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Leptogenesis in SO(10) with minimal Yukawa sector

Journal of High Energy Physics
In prior studies, a very minimal Yukawa sector within the SO(10) Grand Unified Theory framework has been identified, comprising of Higgs fields belonging to a real 10 H , a real 120 H , and a 126 ¯ H $$ {\overline{126}}_H $$ dimensional representations ...
K. S. Babu, Pasquale Di Bari, Chee Sheng Fong, Shaikh Saad   +3 more
doaj   +1 more source

Religious Nationalism: Narendra Modi’s 2019 Election Victory Speech

Religions
The ideology of nationalism is permeating and ascending across societies, eventually manifesting materially in several nations across the world. In this essay, I analyze the religious manifestation of nationalism within the context of India’s Hindu ...
Nihar Sreepada
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source