Results 101 to 110 of about 704,450 (240)

Grand unification through gravitational effects

, 2010
We systematically study the unification of gauge couplings in the presence of (one or more) effective dimension-5 operators cHG(mu v)G(mu v)/4M(pl), induced into the grand unified theory by gravitational interactions at the Planck scale.
Stephen D H Hsu (16064510), Xavier Calmet (4462561), David Reeb (16074623)   +2 more
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Grand-Unification effects in the soft supersymmetry breaking terms

, 2021
In minimal supergravity theories the soft supersymmetry breaking (SSB) parameters are universal near the Planck scale. Nevertheless, one often assumes universality at the grand-unification scale MG≈1016 GeV, and corrections to the SSB parameters arising ...
Pomarol Clotet, Àlex, Polonsky, Nir, American Physical Society   +2 more
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

The global B − L symmetry in the flavor-unified SU(N) theories

Journal of High Energy Physics
We study the origin of the global B − L symmetry in a class of flavor-unified theories with gauge groups of SU(N ≥ 6). In particular, we focus on the SU(8) theory which can minimally embed three-generational SM fermions non-trivially.
Ning Chen, Ying-nan Mao, Zhaolong Teng
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Leptogenesis in SO(10) with minimal Yukawa sector

Journal of High Energy Physics
In prior studies, a very minimal Yukawa sector within the SO(10) Grand Unified Theory framework has been identified, comprising of Higgs fields belonging to a real 10 H , a real 120 H , and a 126 ¯ H $$ {\overline{126}}_H $$ dimensional representations ...
K. S. Babu, Pasquale Di Bari, Chee Sheng Fong, Shaikh Saad   +3 more
doaj   +1 more source