Results 91 to 100 of about 704,450 (240)

Spontaneous CP violation and leptogenesis in SO(10)

Journal of High Energy Physics
We present a renormalizable SO(10) grand unified theory with a minimal Yukawa sector consisting of a 126 H , a real 10 H and a real 120 H , where CP violation has a spontaneous origin.
K. S. Babu, Chee Sheng Fong, Shaikh Saad
doaj   +1 more source

Newton's Idea and Practice of Unification [PDF]

, 2004
In this paper I try to capture Newton's notion and practice of unification (I will mainly focus on the Principia). I will use contemporary theories on unification in philosophy of science as analytic tools (Kitcher, Schurz and Salmon).
Ducheyne, Steffen
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Small instantons and the post-inflationary QCD axion in a special product GUT

Journal of High Energy Physics
We present a new framework of grand unification that is equipped with an axion solution to the strong CP problem without a domain wall problem when the Peccei-Quinn (PQ) symmetry is spontaneously broken after inflation.
Shihwen Hor, Yuichiro Nakai, Motoo Suzuki, Junxuan Xu   +3 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Search for Z′, vacuum (in)stability and hints of high-energy structures

EPJ Web of Conferences, 2016
We study the high-energy behaviour of a class of anomaly-free abelian extensions of the Standard Model. We focus on the interplay among the phenomenological characterisation of the model and the use of precise renormalisation group methods.
Accomando Elena, Corianò Claudio, Delle Rose Luigi, Fiaschi Juri, Marzo Carlo, Moretti Stefano   +5 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

A realistic theory of E6 unification through novel intermediate symmetries

Journal of High Energy Physics
We propose a non-supersymmetric E6 GUT with the scalar sector consisting of 650 ⨁ 351′ ⨁ 27. Making use of the first representation for the initial symmetry breaking to an intermediate stage, and the latter two representations for second-stage breaking ...
K. S. Babu, Borut Bajc, Vasja Susič
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source