Results 91 to 100 of about 102,001 (282)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
, 2012 Five elementary lectures delivered at TASI 2011 on the Standard Model, its extensions to neutrino masses, flavor symmetries, and Grand ...
Ramond, Pierre
core +1 more source
Effects of an intermediate scale in SUSY grand unification
, 1996 We discuss the production of lepton flavor violation and EDMs and the viability of the $b-\tau$ unification hypothesis in SUSY grand unification with an intermediate gauge symmetry breaking scale.Comment: 3 pages (Latex, esprc2.sty used), talk given at ...
B. Dutta +13 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
A realistic theory of E6 unification through novel intermediate symmetries
Journal of High Energy PhysicsWe propose a non-supersymmetric E6 GUT with the scalar sector consisting of 650 ⨁ 351′ ⨁ 27. Making use of the first representation for the initial symmetry breaking to an intermediate stage, and the latter two representations for second-stage breaking ...
K. S. Babu, Borut Bajc, Vasja Susič
doaj +1 more source
Gauge unification in noncommutative geometry
, 2007 Gauge unification is widely considered to be a desirable feature for extensions of the standard model. Unfortunately the standard model itself does not exhibit a unification of its running gauge couplings but it is required by grand unified theories as ...
Stephan, C. A.
core +2 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source
The gauge coupling evolutions of an SU(8) theory with the maximally symmetry breaking pattern
Journal of High Energy PhysicsWe study the renormalizable group equations (RGEs) of the extended strong and weak gauge couplings in an SU(8) theory, where three-generational SM fermions are non-trivially embedded.
Ning Chen +3 more
doaj +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source