Results 71 to 80 of about 704,450 (240)
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Grand Unification at the Subcomponent Level
, 1980 The Casalbuoni-Gatto subcomponent model of quarks and leptons is generalized allowing for an arbitrary number of subcomponents. It is shown that there are only a limited number of cases where the subcolour can be embedded in a semi-simple grand ...
Montvay, Istvan
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Five dimensional $$SU(5) \times U(1)_\textrm{PQ}$$ S U ( 5 ) × U ( 1 ) PQ grand unification
European Physical Journal C: Particles and FieldsWe propose a grand unified model in five dimensions that addresses the strong CP problem. In this framework, the boundary conditions that break the unified gauge group into the Standard Model gauge group simultaneously explain the mass splitting of the ...
Norimi Yokozaki, Junhao Zhu
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Supersymmetry and grand unification [PDF]
, 1995 Supersymmetry and Grand Unification are the two most promising directions for physics beyond the Standard Model. They receive indirect experimental support from the apparent lightness of the Higgs boson, the values of the gauge couplings measured at LEP ...
Ellis, John R.
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The gauge coupling evolutions of an SU(8) theory with the maximally symmetry breaking pattern
Journal of High Energy PhysicsWe study the renormalizable group equations (RGEs) of the extended strong and weak gauge couplings in an SU(8) theory, where three-generational SM fermions are non-trivially embedded.
Ning Chen +3 more
doaj +1 more source