Results 61 to 70 of about 759,547 (247)
Grand unification for mirror fermions
, 1994 The possibility of grand unification of the standard model (SM) with fermion spectrum extended to include mirror fermions is examined. SM gauge couplings do not automatically unify.
Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany) +3 more
core +2 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Asymptotic grand unification in SO(10) with one extra dimension
Journal of High Energy PhysicsAsymptotic grand unification provides an alternative approach to gradually unify gauge couplings in the UV limit, where they reach a non-trivial UV fixed point.
Gao-Xiang Fang +2 more
doaj +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Five dimensional $$SU(5) \times U(1)_\textrm{PQ}$$ S U ( 5 ) × U ( 1 ) PQ grand unification
European Physical Journal C: Particles and FieldsWe propose a grand unified model in five dimensions that addresses the strong CP problem. In this framework, the boundary conditions that break the unified gauge group into the Standard Model gauge group simultaneously explain the mass splitting of the ...
Norimi Yokozaki, Junhao Zhu
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The gauge coupling evolutions of an SU(8) theory with the maximally symmetry breaking pattern
Journal of High Energy PhysicsWe study the renormalizable group equations (RGEs) of the extended strong and weak gauge couplings in an SU(8) theory, where three-generational SM fermions are non-trivially embedded.
Ning Chen +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Grand unification and cosmology
, 1980 The authors show that there are many issues in which cosmology and grand unification do have things to say to each other, though the utility of some of the connections is not yet clear. (57 refs)
D. V. Nanopoulos +5 more
core +1 more source