Results 41 to 50 of about 759,547 (247)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Seeing higher-dimensional grand unification in primordial non-gaussianities

Journal of High Energy Physics, 2019
The observed low-energy values of the SU(3) × SU(2) × U(1) gauge couplings, extrapolated via the minimal Standard Model Renormalization Group evolution, hint at the exciting possibility of a Grand Unified Theory (GUT) at M U ∼ 1014 GeV — a scale, however,
Soubhik Kumar, Raman Sundrum
doaj   +1 more source

Nilpotent symmetries as a mechanism for Grand Unification

Journal of High Energy Physics, 2021
In the classic Coleman-Mandula no-go theorem which prohibits the unification of internal and spacetime symmetries, the assumption of the existence of a positive definite invariant scalar product on the Lie algebra of the internal group is essential.
Lars Andersson, András László, Błażej Ruba   +2 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Newton's Idea and Practice of Unification [PDF]

, 2004
In this paper I try to capture Newton's notion and practice of unification (I will mainly focus on the Principia). I will use contemporary theories on unification in philosophy of science as analytic tools (Kitcher, Schurz and Salmon).
Ducheyne, Steffen
core  

Yukawa unification with four Higgs doublets in supersymmetric GUT

Physics Letters B, 2019
We discuss the Yukawa coupling unification, which can emerge in the grand unified theory, in the context of scenarios with more than one pair of Higgs doublet since the current LHC constraint has become a problem for the Yukawa unification scenarios with
Bhaskar Dutta, Yukihiro Mimura
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Gauge coupling unification in gauge-Higgs GUT: theory and phenomenology

Journal of High Energy Physics
We present a concise survey of the running of gauge couplings in realistic models of gauge-Higgs grand unification in a slice of AdS5 space and investigate their potential unification. Besides unifying the gauge groups of the Standard Model, these models
Andrei Angelescu, Andreas Bally, Florian Goertz, Sascha Weber   +3 more
doaj   +1 more source

The Weinberg angle and 5D RGE effects in a SO(11) GUT theory

Physics Letters B, 2020
The Weinberg angle is an important parameter in Grand Unified Theories (GUT) as its size is crucially influenced by the assumption of unification. In scenarios with different steps of symmetry breaking, in particular in models that involve gauge-Higgs ...
Christoph Englert, David J. Miller, Dumitru Dan Smaranda   +2 more
doaj   +1 more source