Results 41 to 50 of about 3,076 (299)
Trinification from E 6 symmetry breaking
Journal of High Energy Physics, 2023 In the context of E6 Grand Unified Theories (GUTs), an intriguing possibility for symmetry breaking to the Standard Model (SM) group involves an intermediate stage characterized by either SU(3) × SU(3) × SU(3) (trinification) or SU(6) × SU(2).
K. S. Babu, Borut Bajc, Vasja Susič
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Journal of High Energy PhysicsThe SO(10) model with a heavy Higgs spectrum consisting of 560 + 560 ¯ $$ \overline{560} $$ and a light Higgs spectrum consisting of 2 10 + 320 plet representations of SO(10) is unique among SO(10) models.
Jinzheng Li, Pran Nath, Raza M. Syed
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
The unification in an su ̂ 8 k U = 1 $$ \hat{su}{(8)}_{k_U=1} $$ affine Lie algebra
Journal of High Energy PhysicsA flavor-unified theory based on the simple Lie algebra of su $$ \mathfrak{su} $$ (8) was previously proposed to generate the observed three-generational Standard Model quark/lepton mass hierarchies and the Cabibbo-Kobayashi-Maskawa mixing pattern due to
Ning Chen, Zhanpeng Hou, Zhaolong Teng
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The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
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Fermion masses and mixings in supersymmetric SO(10) with third-generation quasi-Yukawa unification
Journal of High Energy PhysicsWe discuss the charged and neutral fermion masses and mixings in a supersymmetric SO(10) model with a minimal Higgs sector consisting of the multiplets 10 H , 45 H , and $${16}_{H}+{\overline{16} }_{H}$$ .
Shaikh Saad, Qaisar Shafi
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
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Neutrino masses, δ PMNS, and m ββ in SO(10)
Journal of High Energy PhysicsWe explore the leptonic sector of a recently proposed supersymmetric SO(10) model with supersymmetry breaking in the 3–10 TeV range. A new ingredient in this work is the requirement that the observed baryon asymmetry is explained via non-thermal ...
Shaikh Saad, Qaisar Shafi
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