Results 31 to 40 of about 759,547 (247)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Fermion masses and mixings in supersymmetric SO(10) with third-generation quasi-Yukawa unification
Journal of High Energy PhysicsWe discuss the charged and neutral fermion masses and mixings in a supersymmetric SO(10) model with a minimal Higgs sector consisting of the multiplets 10 H , 45 H , and $${16}_{H}+{\overline{16} }_{H}$$ .
Shaikh Saad, Qaisar Shafi
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Neutrino masses, δ PMNS, and m ββ in SO(10)
Journal of High Energy PhysicsWe explore the leptonic sector of a recently proposed supersymmetric SO(10) model with supersymmetry breaking in the 3–10 TeV range. A new ingredient in this work is the requirement that the observed baryon asymmetry is explained via non-thermal ...
Shaikh Saad, Qaisar Shafi
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Implications of gravitational waves for supersymmetric grand unification [PDF]
, 2021 Supersymmetric grand unification based on SO(10) is one of the most attractive paradigms in physics beyond the Standard Model. Inspired by the recent NANOGrav signal, we discuss the implications of detecting a stochastic gravitational wave background ...
Zheng, Jiaming +2 more
core +1 more source
Probing grand unification with quantum sensors
Physics Letters BWe discuss how grand unification can be probed with experiments at low energies using quantum sensors. Specifically, we show that scalar multiplets coupled to the gauge sector of a grand unified theory provide a mechanism for a time-varying unified ...
Xavier Calmet, Nathaniel Sherrill
doaj +1 more source