Results 51 to 60 of about 3,076 (299)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Probing grand unification with quantum sensors

Physics Letters B
We discuss how grand unification can be probed with experiments at low energies using quantum sensors. Specifically, we show that scalar multiplets coupled to the gauge sector of a grand unified theory provide a mechanism for a time-varying unified ...
Xavier Calmet, Nathaniel Sherrill
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Nilpotent symmetries as a mechanism for Grand Unification

Journal of High Energy Physics, 2021
In the classic Coleman-Mandula no-go theorem which prohibits the unification of internal and spacetime symmetries, the assumption of the existence of a positive definite invariant scalar product on the Lie algebra of the internal group is essential.
Lars Andersson, András László, Błażej Ruba   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Seeing higher-dimensional grand unification in primordial non-gaussianities

Journal of High Energy Physics, 2019
The observed low-energy values of the SU(3) × SU(2) × U(1) gauge couplings, extrapolated via the minimal Standard Model Renormalization Group evolution, hint at the exciting possibility of a Grand Unified Theory (GUT) at M U ∼ 1014 GeV — a scale, however,
Soubhik Kumar, Raman Sundrum
doaj   +1 more source

GAUGE: the GrAnd Unification and Gravity Explorer [PDF]

Experimental Astronomy, 2008
The GAUGE (GrAnd Unification and Gravity Explorer) mission proposes to use a drag-free spacecraft platform onto which a number of experiments are attached. They are designed to address a number of key issues at the interface between gravity and unification with the other forces of nature.
Amelino-Camelia, G., Aplin, K., Arndt, M., D. Barrow, J., J. Bingham, R., Borde, C., Bouyer, Philippe, Caldwell, M., M. Cruise, A., Damour, T., d'Arrigo, P., Dittus, H., Ertmer, W., Foulon, B., Gill, P., D. Hammond, G., Hough, J., Jentsch, C., Johann, U., Jetzer, P., Klein, H., Lambrecht, A., Lamine, B., Lämmerzahl, C., Lockerbie, N., Loeffler, F., T. Mendonca, J., Mester, J., Ni, W.-T., Pegrum, C., Peters, A., Rasel, E., Reynaud, S., Shaul, D., J. Sumner, T., Theil, S., Torrie, C., Touboul, P., Trenkel, C., Vitale, S., Vodel, W., Wang, Chen, Ward, H., Woodgate, A.   +43 more
openaire   +9 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Anatomy of scalar mediated proton decays in SO(10) models

Journal of High Energy Physics, 2022
Realistic models based on the renormalizable grand unified theories have varieties of scalars, many of which are capable of mediating baryon (B) and lepton (L) number non-conserving processes.
Ketan M. Patel, Saurabh K. Shukla
doaj   +1 more source