Results 51 to 60 of about 759,547 (247)

Electroweak flavour unification

Journal of High Energy Physics, 2022
We propose that the electroweak and flavour quantum numbers of the Standard Model (SM) could be unified at high energies in an SU(4) × Sp(6) L × Sp(6) R anomaly-free gauge model. All the SM fermions are packaged into two fundamental fields, Ψ L ∼ (4 , 6 ,
Joe Davighi, Joseph Tooby-Smith
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Anatomy of scalar mediated proton decays in SO(10) models

Journal of High Energy Physics, 2022
Realistic models based on the renormalizable grand unified theories have varieties of scalars, many of which are capable of mediating baryon (B) and lepton (L) number non-conserving processes.
Ketan M. Patel, Saurabh K. Shukla
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Tri-unification: a separate SU(5) for each fermion family

Journal of High Energy Physics
In this paper we discuss SU(5)3 with cyclic symmetry as a possible grand unified theory (GUT). The basic idea of such a tri-unification is that there is a separate SU(5) for each fermion family, with the light Higgs doublet(s) arising from the third ...
Mario Fernández Navarro, Stephen F. King, Avelino Vicente   +2 more
doaj   +1 more source

Predictive power of grand unification from quantum gravity

Journal of High Energy Physics, 2020
If a grand-unified extension of the asymptotically safe Reuter fixed-point for quantum gravity exists, it determines free parameters of the grand-unified scalar potential. All quartic couplings take their fixed-point values in the trans-Planckian regime.
Astrid Eichhorn, Aaron Held, Christof Wetterich   +2 more
doaj   +1 more source

Probing minimal grand unification through gravitational waves, proton decay, and fermion masses

Journal of High Energy Physics, 2023
Motivated by the direct discovery of gravitational waves (GWs) from black holes and neutron stars, there is a growing interest in investigating GWs from other sources.
Shaikh Saad
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Implications of a dark grand unification

Journal of High Energy Physics
Given that dark matter and normal matter are nontrivially unified in a grand unified theory, called dark grand unification, we derive novel residual theories at low energy explaining dark matter and neutrino mass.
Phung Van Dong, Do Thi Huong
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source