Results 51 to 60 of about 102,001 (282)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Fermion masses and mixings in supersymmetric SO(10) with third-generation quasi-Yukawa unification

Journal of High Energy Physics
We discuss the charged and neutral fermion masses and mixings in a supersymmetric SO(10) model with a minimal Higgs sector consisting of the multiplets 10 H , 45 H , and $${16}_{H}+{\overline{16} }_{H}$$ .
Shaikh Saad, Qaisar Shafi
doaj   +1 more source

Grand Unification on Noncommutative Spacetime [PDF]

, 2006
We compute the beta-functions of the standard model formulated on a noncommutative spacetime. If we assume that the scale for spacetime noncommutativity is of the order of 2.2 \times 10^{15} GeV we find that the three gauge couplings of the standard ...
Calmet, Xavier
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Neutrino masses, δ PMNS, and m ββ in SO(10)

Journal of High Energy Physics
We explore the leptonic sector of a recently proposed supersymmetric SO(10) model with supersymmetry breaking in the 3–10 TeV range. A new ingredient in this work is the requirement that the observed baryon asymmetry is explained via non-thermal ...
Shaikh Saad, Qaisar Shafi
doaj   +1 more source

Induced gravity II: grand unification [PDF]

Journal of High Energy Physics, 2016
44 pages, 5 figures, 2 tables. v2 has new discussion concerning stability of SSB plus related appendix. Additional references added.
Einhorn, Martin, Jones, D.R.
openaire   +4 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Probing grand unification with quantum sensors

Physics Letters B
We discuss how grand unification can be probed with experiments at low energies using quantum sensors. Specifically, we show that scalar multiplets coupled to the gauge sector of a grand unified theory provide a mechanism for a time-varying unified ...
Xavier Calmet, Nathaniel Sherrill
doaj   +1 more source