Results 51 to 60 of about 1,383 (257)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Yukawa unification with four Higgs doublets in supersymmetric GUT
Physics Letters B, 2019 We discuss the Yukawa coupling unification, which can emerge in the grand unified theory, in the context of scenarios with more than one pair of Higgs doublet since the current LHC constraint has become a problem for the Yukawa unification scenarios with
Bhaskar Dutta, Yukihiro Mimura
doaj +1 more source
Electroweak flavour unification
Journal of High Energy Physics, 2022 We propose that the electroweak and flavour quantum numbers of the Standard Model (SM) could be unified at high energies in an SU(4) × Sp(6) L × Sp(6) R anomaly-free gauge model. All the SM fermions are packaged into two fundamental fields, Ψ L ∼ (4 , 6 ,
Joe Davighi, Joseph Tooby-Smith
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Gauge coupling unification in gauge-Higgs GUT: theory and phenomenology
Journal of High Energy PhysicsWe present a concise survey of the running of gauge couplings in realistic models of gauge-Higgs grand unification in a slice of AdS5 space and investigate their potential unification. Besides unifying the gauge groups of the Standard Model, these models
Andrei Angelescu +3 more
doaj +1 more source
The Weinberg angle and 5D RGE effects in a SO(11) GUT theory
Physics Letters B, 2020 The Weinberg angle is an important parameter in Grand Unified Theories (GUT) as its size is crucially influenced by the assumption of unification. In scenarios with different steps of symmetry breaking, in particular in models that involve gauge-Higgs ...
Christoph Englert +2 more
doaj +1 more source
Anatomy of scalar mediated proton decays in SO(10) models
Journal of High Energy Physics, 2022 Realistic models based on the renormalizable grand unified theories have varieties of scalars, many of which are capable of mediating baryon (B) and lepton (L) number non-conserving processes.
Ketan M. Patel, Saurabh K. Shukla
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Probing minimal grand unification through gravitational waves, proton decay, and fermion masses
Journal of High Energy Physics, 2023 Motivated by the direct discovery of gravitational waves (GWs) from black holes and neutron stars, there is a growing interest in investigating GWs from other sources.
Shaikh Saad
doaj +1 more source
Grand unification in higher dimensions [PDF]
Annals of Physics, 2003 We have recently proposed an alternative picture for the physics at the scale of gauge coupling unification, where the unified symmetry is realized in higher dimensions but is broken locally by a symmetry breaking defect. Gauge coupling unification, the quantum numbers of quarks and leptons and the longevity of the proton arise as phenomena of the ...
Hall, Lawrence J., Nomura, Yasunori
openaire +3 more sources