Results 51 to 60 of about 704,450 (240)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

SU(9) grand unified model with rank-reducing discrete boundary conditions on T 2 /ℤ4

Journal of High Energy Physics
We study a six-dimensional SU(9) grand unified model with rank-reducing discrete boundary conditions and continuous Wilson line phases on the orbifold T 2 /ℤ4.
Yoshiharu Kawamura, Kentaro Kojima, Toshifumi Yamashita   +2 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Grand-Unification effects in the soft supersymmetry breaking terms [PDF]

, 1994
In minimal supergravity theories the soft supersymmetry breaking (SSB) parameters are universal near the Planck scale. Nevertheless, one often assumes universality at the grand-unification scale MG≈1016 GeV, and corrections to the SSB parameters arising ...
Pomarol Clotet, Àlex, Polonsky, Nir, American Physical Society   +2 more
core   +2 more sources

Seeing higher-dimensional grand unification in primordial non-gaussianities

Journal of High Energy Physics, 2019
The observed low-energy values of the SU(3) × SU(2) × U(1) gauge couplings, extrapolated via the minimal Standard Model Renormalization Group evolution, hint at the exciting possibility of a Grand Unified Theory (GUT) at M U ∼ 1014 GeV — a scale, however,
Soubhik Kumar, Raman Sundrum
doaj   +1 more source

Nilpotent symmetries as a mechanism for Grand Unification

Journal of High Energy Physics, 2021
In the classic Coleman-Mandula no-go theorem which prohibits the unification of internal and spacetime symmetries, the assumption of the existence of a positive definite invariant scalar product on the Lie algebra of the internal group is essential.
Lars Andersson, András László, Błażej Ruba   +2 more
doaj   +1 more source

Polychromatic Grand Unification [PDF]

, 2003
The possibility of achieving a gauge coupling grand unification by increasing the QCD degrees of freedom at higher energies is investigated. When confronted with precision low-energy data, the generic weak-mixing angle relation sin^2(theta_W) = N/2(N+1 ...
Gonzalez Felipe, R., Gérard, Jean-Marc, Branco, Gustavo Castello, Gérard, J M, Nobre, B M, Nobre, B.M., Felipe, R G, Branco, G.C.   +7 more
core  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source