Results 81 to 90 of about 704,450 (240)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Reality-constrained minimal Yukawa structure in SO(10) GUT
Journal of High Energy PhysicsWe investigate the minimal Yukawa sector of grand unified theories based on SO(10) symmetry, consisting of a Higgs structure with representations 10 ℝ ⊕ 120 ℝ ⊕ 126.
Shaikh Saad, Vasja Susič
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Introduction to grand unification theories [PDF]
, 1980 The Georgi-Glashow model is introduced based on the minimal gauge group SU(5) as a prototype grand unification theory of the electroweak and strong interactions.
Kang, K.
core
Three-Family SO(10) Grand Unification in String Theory
, 1996 The construction of a supersymmetric SO(10) grand unification with 5 left-handed and 2 right-handed families in the four-dimensional heterotic string theory is presented. The model has one SO(10) adjoint Higgs field.
Zurab Kakushadze +3 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
A modular SU (5) littlest seesaw
Journal of High Energy PhysicsWe extend the littlest modular seesaw to a Grand Unified scenario based on SU (5) endowed with three modular S 4 symmetries. We leverage symmetry protected zeroes in the leptonic and down quark sectors to suppress deviations to the littlest modular ...
Ivo de Medeiros Varzielas +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Search for grand unification groups
, 2012 Thesis (Ph. D.)--University of Rochester. Dept. of Physics and Astronomy, 1981.The search for a local symmetry group for grand unified theories is carried out, using group-theoretical techniques.
Tosa, Yasunari, Okubo, Susumu (1930 - )
core
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source