Results 81 to 90 of about 759,547 (247)
Grand unification and enhanced quantum gravitational effects [PDF]
, 2008 In grand unified theories with large numbers of fields, renormalization effects significantly modify the scale at which quantum gravity becomes strong.
Stephen D H Hsu (16064510) +6 more
core +1 more source
Small instantons and the post-inflationary QCD axion in a special product GUT
Journal of High Energy PhysicsWe present a new framework of grand unification that is equipped with an axion solution to the strong CP problem without a domain wall problem when the Peccei-Quinn (PQ) symmetry is spontaneously broken after inflation.
Shihwen Hor +3 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Flavor tests of grand unification [PDF]
, 1995 How will we ever be convinced that grand unification, or string theory, or some other physics at very high energies, is correct? Two ways in which this could happen are: The structure of the theory is itself so compelling and tightly constrained, and the
Hall, L J, Hall, L. J., Hall, L.J.
core
Search for Z′, vacuum (in)stability and hints of high-energy structures
EPJ Web of Conferences, 2016 We study the high-energy behaviour of a class of anomaly-free abelian extensions of the Standard Model. We focus on the interplay among the phenomenological characterisation of the model and the use of precise renormalisation group methods.
Accomando Elena +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
A realistic theory of E6 unification through novel intermediate symmetries
Journal of High Energy PhysicsWe propose a non-supersymmetric E6 GUT with the scalar sector consisting of 650 ⨁ 351′ ⨁ 27. Making use of the first representation for the initial symmetry breaking to an intermediate stage, and the latter two representations for second-stage breaking ...
K. S. Babu, Borut Bajc, Vasja Susič
doaj +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Grand Unification at the Subcomponent Level
, 1980 The Casalbuoni-Gatto subcomponent model of quarks and leptons is generalized allowing for an arbitrary number of subcomponents. It is shown that there are only a limited number of cases where the subcolour can be embedded in a semi-simple grand ...
Montvay, Istvan
core +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source