Results 81 to 90 of about 1,383 (257)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Spontaneous CP violation and leptogenesis in SO(10)

Journal of High Energy Physics
We present a renormalizable SO(10) grand unified theory with a minimal Yukawa sector consisting of a 126 H , a real 10 H and a real 120 H , where CP violation has a spontaneous origin.
K. S. Babu, Chee Sheng Fong, Shaikh Saad
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Small instantons and the post-inflationary QCD axion in a special product GUT

Journal of High Energy Physics
We present a new framework of grand unification that is equipped with an axion solution to the strong CP problem without a domain wall problem when the Peccei-Quinn (PQ) symmetry is spontaneously broken after inflation.
Shihwen Hor, Yuichiro Nakai, Motoo Suzuki, Junxuan Xu   +3 more
doaj   +1 more source

Grand unification and exotic fermions

Physical Review D, 2015
We exploit the recently developed software package LieART to show that SU(N) grand unified theories with chiral fermions in mixed tensor irreducible representations can lead to standard model chiral fermions without additional light exotic chiral fermions, i.e., only standard model fermions are light in these models.
Feger, Robert P., Kephart, Thomas W.
openaire   +3 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Search for Z′, vacuum (in)stability and hints of high-energy structures

EPJ Web of Conferences, 2016
We study the high-energy behaviour of a class of anomaly-free abelian extensions of the Standard Model. We focus on the interplay among the phenomenological characterisation of the model and the use of precise renormalisation group methods.
Accomando Elena, Corianò Claudio, Delle Rose Luigi, Fiaschi Juri, Marzo Carlo, Moretti Stefano   +5 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

A realistic theory of E6 unification through novel intermediate symmetries

Journal of High Energy Physics
We propose a non-supersymmetric E6 GUT with the scalar sector consisting of 650 ⨁ 351′ ⨁ 27. Making use of the first representation for the initial symmetry breaking to an intermediate stage, and the latter two representations for second-stage breaking ...
K. S. Babu, Borut Bajc, Vasja Susič
doaj   +1 more source

Grand Unification in the Projective Plane [PDF]

Journal of High Energy Physics, 2004
A 6-dimensional grand unified theory with the compact space having the topology of a real projective plane, i.e., a 2-sphere with opposite points identified, is considered. The space is locally flat except for two conical singularities where the curvature is concentrated. One supersymmetry is preserved in the effective 4d theory.
openaire   +3 more sources