Results 261 to 270 of about 160,405 (309)

Intelligent granules: Are eosinophil crystalloid granules inimitable?

Journal of Allergy and Clinical Immunology, 2010
The controversy surrounding the effector function of eosinophils in health and disease continues at both the clinical and basic discovery levels. Two recent studies reported that an anti-human IL-5 mAb (mepolizumab) specifically targeting eosinophils significantly reduced asthma exacerbations, providing interesting insights into the potential role of ...
Salahaddin, Mahmudi-Azer, S O Wole, Odemuyiwa, Redwan, Moqbel   +2 more
openaire   +2 more sources

Microbial communities of aerobic granules: Granulation mechanisms

Bioresource Technology, 2014
Aerobic granulation is an advanced biological wastewater treatment technology. This study for the first time identified the microbial communities of sliced samples of mature granules by polymerase chain reaction (PCR) amplification and denaturing gradient gel electrophoresis (DGGE) technique and those of whole growing granules by high-throughput ...
Yi, Lv, Chunli, Wan, Duu-Jong, Lee, Xiang, Liu, Joo-Hwa, Tay   +4 more
openaire   +2 more sources

Granulation of Acetaminophen by a Rotating Fluidized-Bed Granulator

Pharmaceutical Development and Technology, 2000
The purpose of this research was to evaluate the use of a rotating fluidized-bed granulator to produce acetaminophen granules with sufficient binding force between particles and good plasticity in tablets. Ethenzamide and ascorbic acid were used to compare the relationship between granulation and the sample wetness.
T, Kawaguchi, H, Sunada, Y, Yonezawa, K, Danjo, M, Hasegawa, T, Makino, H, Sakamoto, K, Fujita, T, Tanino, H, Kokubo   +9 more
openaire   +2 more sources

Effect of the Granulation Process on Nitrofurantoin Granule Characteristics

Drug Development and Industrial Pharmacy, 1998
We studied four granulation methods on the same quantitative and qualitative formula: wet massing by forced agglomeration (Lödige) and free agglomeration (Glatt); and dry massing by slugging and roller compaction technique. Three different particle sizes of nitrofurantoin (bioinequivalent drug) were used. The nitrofurantoin particle size has a very low
P, Arnaud, D, Brossard, J C, Chaumeil
openaire   +2 more sources

Coalescence of deformable granules in wet granulation processes

AIChE Journal, 2000
AbstractIn this work, the coalescence of deformable granules in wet granulation processes is modelled. The model accounts for both the mechanical properties of the granules and the effect of the liquid layer at the granule surface. It is an extension to the model of Ennis et al.
Liu, L. X., Litster, J. D., Iveson, S. M., Ennis, B. J.   +3 more
openaire   +3 more sources

Effects of High-Shear Granulation on Granulate Homogeneity

Pharmaceutical Development and Technology, 1999
This study considers the effects of particle size of the powder constituents, and of impeller speed on the homogeneity of drug distribution on granulations produced in high-speed mixers. When a micronized low-dose steroid hormone was granulated together with unmicronized lactose in a Vactron 75 high-shear granulator at 250 rpm, strong inhomogeneities ...
H, Vromans, H G, Poels-Janssen, H, Egermann   +2 more
openaire   +2 more sources

Twin screw granulation: Steps in granule growth

International Journal of Pharmaceutics, 2012
The present work focuses on the study of the progression of granules in different compartments along the length of screws in a twin screw granulator (TSG). The effects of varying powder feed rate; liquid to solid ratio and viscosity of granulation liquid on properties of granules was studied.
Ranjit M, Dhenge, James J, Cartwright, Michael J, Hounslow, Agba D, Salman   +3 more
openaire   +2 more sources

Roles of Granule Size in Over-Granulation During High Shear Wet Granulation

Journal of Pharmaceutical Sciences, 2010
A mechanistic understanding of the over-granulation problem during high shear wet granulation (HSWG) process can guide efficient development of robust formulation and manufacturing process. Using microcrystalline cellulose (MCC) as a model compound, we demonstrate that size enlargement is an important mechanism for over-granulation in HSWG.
Limin, Shi, Yushi, Feng, Changquan Calvin, Sun   +2 more
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The Relation Between Granule Size, Granule Stickiness, and Torque in the High-Shear Granulation Process

Pharmaceutical Research, 2005
To investigate the background of the observed relationship between measured torque and granule size in high-shear granulation processes.Torque was measured during the granulation process; the behavior of individual wet granules during compaction was investigated using micromanipulation.
Bouwman, A.M., Henstra, M.J., Hegge, J.J.M.E., Zhang, Z., Ingram, A., Seville, J.P.K., Frijlink, H.W.   +6 more
openaire   +3 more sources

A study on the preparation of granules by mixer granulation

Archives of Pharmacal Research, 1979
A first systematic approach on new and simple preparation method of spherical granules in the system using organic granulating solution was carried out. Mixer granulation required narrow range of moisture content but gentle action of tumbling in the mixer and capillary forces were adequate to compact the porous mass and also were highly effective to ...
Kang Choon Lee, Shin Hong Min, Shanghi Rhee, Yong Bae Kim   +3 more
openaire   +1 more source