Results 101 to 110 of about 4,987,565 (306)

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

PTEN deletion from adult-generated dentate granule cells disrupts granule cell mossy fiber axon structure

Neurobiology of Disease, 2015
Dysregulation of the mTOR-signaling pathway is implicated in the development of temporal lobe epilepsy. In mice, deletion of PTEN from hippocampal dentate granule cells leads to mTOR hyperactivation and promotes the rapid onset of spontaneous seizures ...
Candi L. LaSarge, Victor R. Santos, Steve C. Danzer   +2 more
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes

iScience
Summary: In type 2 diabetes (T2D), the rate of insulin secretory granule biogenesis can limit insulin secretion from pancreatic β-cells. Using rat insulinoma INS1 β-cells, we show that the soluble Ca2+-binding/trafficking protein, Cab45G, serves as a non-
Mark Germanos, Belinda Yau, Matthew Taper, Cara Yeoman, Amy Wilson, Yousun An, Jerome Cattin-Ortolá, Drew Masler, Jason Tong, Sheyda Naghiloo, Elise J Needham, A Gabrielle van der Kraan, Kitty Sun, Thomas Loudovaris, Alexis Diaz-Vegas, Mark Larance, Helen Thomas, Helen von Blume, Peter Thorn, Michael Ailion, Cedric Asensio, Melkam Alamerew Kebede   +21 more
doaj   +1 more source

Specific Temporal Distribution and Subcellular Localization of a Functional Vesicular Nucleotide Transporter (VNUT) in Cerebellar Granule Neurons

Frontiers in Pharmacology, 2017
Adenosine triphosphate (ATP) is an important extracellular neurotransmitter that participates in several critical processes like cell differentiation, neuroprotection or axon guidance.
Aida Menéndez-Méndez, Aida Menéndez-Méndez, Aida Menéndez-Méndez, Juan I. Díaz-Hernández, Juan I. Díaz-Hernández, Juan I. Díaz-Hernández, Felipe Ortega, Felipe Ortega, Felipe Ortega, Javier Gualix, Javier Gualix, Javier Gualix, Rosa Gómez-Villafuertes, Rosa Gómez-Villafuertes, Rosa Gómez-Villafuertes, María T. Miras-Portugal, María T. Miras-Portugal, María T. Miras-Portugal   +17 more
doaj   +1 more source

Generation and analysis of mouse lines with a defect in platelet secretion and application in mouse models of atherosclerosis and tumor metastasis [PDF]

, 2013
Introduction: The involvement of platelets in various diseases has been increasingly recognized in the recent decades. This contribution is believed to involve platelet secretion and formation of reactive microparticles.
Schumacher, Dagmar
core  

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Dendritic inhibition differentially regulates excitability of dentate gyrus parvalbumin-expressing interneurons and granule cells

Nature Communications, 2019
Fast-spiking parvalbumin-expressing interneurons (PVIs) and granule cells of the dentate gyrus receive layer-specific dendritic inhibition. The authors show that distal and proximal dendritic inhibition differentially control input-output transformations
Claudio Elgueta, Marlene Bartos
doaj   +1 more source

Near-isotropic, reconstructed volume electron microscopy (FIB-SEM) of mouse cerebellar granule neurons (jrc_mus-granule-neurons-3)

Sample: Cultured mouse cerebellar granule neurons (progenitors) transiently expressing HP1 mEmerald / H3.3 SNAP (JF525) / Lamin B Halo(JF646) Sample Description: Near isotropic FIB-SEM imaging of primary mouse granular neurons to study chromatin domains ...
David Solecki (17069182), Harald Hess (9463530), Gleb Shtengel (9533472), CellMap Project Team (14322654), Nirmala Iyer (9537812), C. Shan Xu (9463533)   +5 more
core   +1 more source

Temporal profile of hilar basal dendrite formation on dentate granule cells after status epilepticus [PDF]

, 2003
Granule cells with hilar basal dendrites (HBDs) are found after status epilepticus (SE) in three rat models of temporal lobe epilepsy. These granule cells are commonly located at the hilar border and could be newly born granule cells based on their ...
Dashtipour, Khashayar, Obenaus, Andre, Spigelman, Igor, Ribak, Charles E, Wong, Alan M   +4 more
core   +1 more source