Results 101 to 110 of about 259,502 (294)

Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes

iScience
Summary: In type 2 diabetes (T2D), the rate of insulin secretory granule biogenesis can limit insulin secretion from pancreatic β-cells. Using rat insulinoma INS1 β-cells, we show that the soluble Ca2+-binding/trafficking protein, Cab45G, serves as a non-
Mark Germanos, Belinda Yau, Matthew Taper, Cara Yeoman, Amy Wilson, Yousun An, Jerome Cattin-Ortolá, Drew Masler, Jason Tong, Sheyda Naghiloo, Elise J Needham, A Gabrielle van der Kraan, Kitty Sun, Thomas Loudovaris, Alexis Diaz-Vegas, Mark Larance, Helen Thomas, Helen von Blume, Peter Thorn, Michael Ailion, Cedric Asensio, Melkam Alamerew Kebede   +21 more
doaj   +1 more source

Dendritic inhibition differentially regulates excitability of dentate gyrus parvalbumin-expressing interneurons and granule cells

Nature Communications, 2019
Fast-spiking parvalbumin-expressing interneurons (PVIs) and granule cells of the dentate gyrus receive layer-specific dendritic inhibition. The authors show that distal and proximal dendritic inhibition differentially control input-output transformations
Claudio Elgueta, Marlene Bartos
doaj   +1 more source

Specific Temporal Distribution and Subcellular Localization of a Functional Vesicular Nucleotide Transporter (VNUT) in Cerebellar Granule Neurons

Frontiers in Pharmacology, 2017
Adenosine triphosphate (ATP) is an important extracellular neurotransmitter that participates in several critical processes like cell differentiation, neuroprotection or axon guidance.
Aida Menéndez-Méndez, Aida Menéndez-Méndez, Aida Menéndez-Méndez, Juan I. Díaz-Hernández, Juan I. Díaz-Hernández, Juan I. Díaz-Hernández, Felipe Ortega, Felipe Ortega, Felipe Ortega, Javier Gualix, Javier Gualix, Javier Gualix, Rosa Gómez-Villafuertes, Rosa Gómez-Villafuertes, Rosa Gómez-Villafuertes, María T. Miras-Portugal, María T. Miras-Portugal, María T. Miras-Portugal   +17 more
doaj   +1 more source

Tuning Amorphous‐Crystalline Catalytic Interfaces by Mechanochemistry: Cu‐Based Metallic Glasses Coupled with Ceria for CO Oxidation

Advanced Materials, EarlyView.
Ball‐milling Cu‐based metallic glasses with ceria creates a unique nanostructure where metallic glass particles are wrapped by CeO2 nanoparticles. The intimate integration triggers copper state reorganization during reaction and aging, boosting CO oxidation and COPrOx activity.
Maahin Mirzay‐Shahim, Mehran Nabahat, Laia Pascua‐Solé, Isabel Serrano, Ilaria Lucentini, Xènia Garcia, Marina Armengol‐Profitós, Asier Agrelo‐Lestón, Ignasi Burgués‐Ceballos, Núria J. Divins, Ignacio J. Villar‐Garcia, Virginia Pérez‐Dieste, Carlos Escudero, Carlo Marini, Jordi Llorca, Eloi Pineda, Pere Bruna, Lluís Soler   +17 more
wiley   +1 more source

In vivo anomalous diffusion and weak ergodicity breaking of lipid granules

, 2011
Combining extensive single particle tracking microscopy data of endogenous lipid granules in living fission yeast cells with analytical results we show evidence for anomalous diffusion and weak ergodicity breaking.
A. N. Kolmogorov, B. D. Hughes, Christine Selhuber-Unkel, Eli Barkai, Jae-Hyung Jeon, Kirstine Berg-Sørensen, Lene Oddershede, Ralf Metzler, Stas Burov, Vincent Tejedor, W. T. Coffey   +10 more
core   +1 more source

High‐Throughput 3D Matrigel‐based Droplet Microfluidics for Single‐Cell Function‐to‐Omics Analysis of Cytotoxic Immune Cells in Solid Tumor Interactions

Advanced Materials Technologies, EarlyView.
A 3D Matrigel‐based droplet microfluidics platform that allows physiologically relevant analysis of single immune‐tumor interactions in solid tumors. By integrating real‐time functional imaging with fluorescence‐activated droplet sorting and RNA sequencing, the system links immune cytotoxic behavior to transcriptomic profiles, providing a scalable ...
Christina Sharkey, Harry Akligoh, Michael Finocchiaro, Abhishek Srihari Rampelli, Zongwei Wang, Aria F. Olumi, Tania Konry   +6 more
wiley   +1 more source

FGF14 Regulates Presynaptic Ca2+ Channels and Synaptic Transmission

Cell Reports, 2013
Fibroblast growth factor homologous factors (FHFs) are not growth factors, but instead bind to voltage-gated Na+ channels (NaV) and regulate their function.
Haidun Yan, Juan L. Pablo, Geoffrey S. Pitt   +2 more
doaj   +1 more source

Anti‐Slip Material‐Based Strategies and Approaches

Advanced Materials Technologies, EarlyView.
This review highlights the principle mechanisms of slipping at the microscale, linking contact mechanics with a friction behavior model for surface interfaces. Main strategies to develop anti‐slip properties to the surfaces are discussed alongside standardized testing approaches.
Sogand Abbaspoor‐Zanjani, Carlo Antonini, Teresa Gatti, Mengjiao Wang   +3 more
wiley   +1 more source

Functional roles of distributed synaptic clusters in the mitral-granule cell network of the olfactory bulb

Frontiers in Integrative Neuroscience, 2010
Odors are encoded in spatio-temporal patterns within the olfactory bulb, but the mechanisms of odor recognition and discrimination are poorly understood.
Michele Migliore, Michele Migliore, Michael Hines, Thomas S McTavish, Gordon M Shepherd   +4 more
doaj   +1 more source

Enhanced Infection Resistance and Regenerative Healing of Titanium Implants via Peptide‐Loaded Biodegradable Coatings

Advanced Materials Technologies, EarlyView.
This study presents a new biodegradable coating for titanium implants using a natural antimicrobial peptide, caerin 1.9. Applied via solvent casting, the coating offers sustained antibacterial protection and promotes healing. Tested on 3D‐printed porous titanium scaffolds, it effectively prevented infection—including against resistant bacteria—while ...
Hejie Li, Tianfang Wang, Nicolas Soro, Guoying Ni, Meg Allom, D. İpek Kurtböke, Xiaosong Liu, Damon Kent   +7 more
wiley   +1 more source