Results 111 to 120 of about 4,987,565 (306)

Near-isotropic, reconstructed volume electron microscopy (FIB-SEM) of mouse cerebellar granule neurons (jrc_mus-granule-neurons-2)

Sample: Cultured mouse cerebellar granule neurons (progenitors) transiently expressing HP1 mEmerald / H3.3 SNAP (JF525) / Lamin B Halo(JF646) Sample Description: Near isotropic FIB-SEM imaging of primary mouse granular neurons to study chromatin domains ...
David Solecki (17069182), Harald Hess (9463530), Gleb Shtengel (9533472), CellMap Project Team (14322654), Nirmala Iyer (9537812), C. Shan Xu (9463533)   +5 more
core   +1 more source

Isolation and Culture of Post-Natal Mouse Cerebellar Granule Neuron Progenitor Cells and Neurons [PDF]

, 2011
The cerebellar cortex is a well described structure that provides unique opportunities for studying neuronal properties and development. Of the cerebellar neuronal types (granule cells, Purkinje cells and inhibitory interneurons), granule neurons are by ...
Mason, Carol A., Manzini, Maria Chiara, Lee, Hae Young, Greene, Lloyd A.   +3 more
core   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Functional roles of distributed synaptic clusters in the mitral-granule cell network of the olfactory bulb

Frontiers in Integrative Neuroscience, 2010
Odors are encoded in spatio-temporal patterns within the olfactory bulb, but the mechanisms of odor recognition and discrimination are poorly understood.
Michele Migliore, Michele Migliore, Michael Hines, Thomas S McTavish, Gordon M Shepherd   +4 more
doaj   +1 more source

Near-isotropic, reconstructed volume electron microscopy (FIB-SEM) of mouse cerebellar granule neurons (jrc_mus-granule-neurons-1)

Sample: Cultured mouse cerebellar granule neurons transiently expressing HP1 mEmerald H3.3 SNAP (JF525) Lamin B Halo (JF646) Sample Description: Near isotropic FIB-SEM imaging of primary mouse granular neurons to study chromatin domains and their ...
David Solecki (17069182), Harald Hess (9463530), Gleb Shtengel (9533472), CellMap Project Team (14322654), Nirmala Iyer (9537812), C. Shan Xu (9463533)   +5 more
core   +1 more source

Number of differentially expressed transcripts in ouabain-treated rat cerebellum granule cells.

, 2019
Number of differentially expressed transcripts in ouabain-treated rat cerebellum granule cells.
Aslan A. Kubatiev (3155346), Tatiana N. Fedorova (7434320), Aleksey A. Moskovtsev (7434326), Larisa V. Smolyaninova (3600053), Alexander V. Lopachev (7434317), Tatiana S. Klementieva (7434323), Alexandra A. Shiyan (7434311), Leonid V. Kapilevich (7434314), Sergei N. Orlov (7434329)   +8 more
core   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

Granule formation is independent of Nab3 expression level.

, 2018
Histogram of the number of cells with a given GFP-Nab3 expression level for both granule-containing and granule-free cells from experiments shown in Fig 7.
Joshua B. Kelley (6090782), Travis J. Loya (4510021), Thomas W. O’Rourke (2557504), William C. Simke (6090779), Daniel Reines (14903)   +4 more
core   +1 more source

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source