Results 121 to 130 of about 4,987,565 (306)

Cerebellar granule cells acquire a widespread predictive feedback signal during motor learning

, 2017
Cerebellar granule cells, which constitute half the brain's neurons, supply Purkinje cells with contextual information necessary for motor learning, but how they encode this information is unknown.
Wang, S.S.-H. (Samuel S-H), Chris I De Zeeuw, Kloth, AD, Gao, Z. Y., Wang, Samuel S-H, Deverett, Ben, De Zeeuw, C. I., Medina, J.F. (Javier F), Ozden, I., Najafi, F. (Farzaneh), Pereira, T.D. (Talmo D), Aleksandra Badura, Ozden, I. (Ilker), Kloth, Alexander D, Samuel S-H Wang, Badura, A.M. (Aleksandra), Kloth, A.D. (Alexander D), Pereira, TD, Gao, Zhenyu, Pnevmatikakis, E. (Eftychios), Medina, Javier F, Ilker Ozden, Pnevmatikakis, E., Deverett, B. (Ben), Talmo D Pereira, Giovannucci, A. (Andrea), Liam Paninski, Pereira, T. D., De Zeeuw, Chris I, Zhenyu Gao, Pnevmatikakis, Eftychios, Najafi, Farzaneh, Eftychios Pnevmatikakis, Pereira, Talmo D, Giovannucci, Andrea, Paninski, L, Paninski, Liam, Badura, A., Badura, Aleksandra, Zeeuw, C.I. (Chris) de, Pnevmatikakis, E, Giovannucci, A., Paninski, L. (Liam), Kloth, A. D., Wang, S. S. H., Javier F Medina, de Zeeuw, Chris, Paninski, L., Ozden, I, Najafi, F., Deverett, B., Gao, Z. (Zhenyu), Andrea Giovannucci, Ben Deverett, Badura, A, Najafi, F, Wang, SSH, Deverett, B, Ozden, Ilker, Giovannucci, A, Medina, JF, Medina, J. F., Alexander D Kloth, Farzaneh Najafi   +63 more
core   +1 more source

The TUBA1B–G3BP2 Axis Sustains p65 Transcriptional Activity to Promote Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
TUBA1B is consistently upregulated in hepatocellular carcinoma and sustains malignant progression by stabilizing G3BP2. By restraining TRIM25‐associated K48‐linked ubiquitination, TUBA1B preserves the G3BP2–IκBα complex and basal NF‐κB/p65 activity. Concurrent TUBA1B/G3BP2 upregulation identifies an aggressive HCC subgroup with enhanced p65 activation ...
Fen Lin, Hechun Lin, Junming Yu, Chao Ge, Lin Mao, Saihua Zhang, Yizi Jin, Yunyu Wu, Taoyang Chen, Jinjun Li, Hong Li   +10 more
wiley   +1 more source

Molecular characterisation of neurotransmitter receptors in the CNS of the stargazer mutant mouse [PDF]

, 2002
The mutant mouse stargazer shows both ataxia and absence epilepsy from P14 onwards. A PGR amplification strategy was utilised to identify adult (i.e. > 3 months) +/stg from +/+ mice, which share the same phenotype, for use for breeding purposes. The same
Tiwari, Priyanka
core  

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

The survival of cultures mouse cerebellar granule cells is not dependent on elevated potassium-ion concentration

, 1994
Neurokemi, cerebellar granule cells, maturation, rat, K*O ...
Balázs, Robert, Jørgensen, Ole Steen, Mogensen, Helle Smidt, Hack, Nicola   +3 more
core   +1 more source

AI‐Powered, Temperature‐Resolved Centrifugal Microfluidics for Rapid 3D Phase‐Diagram Generation of Biomolecular Condensates

Advanced Science, EarlyView.
By merging centrifugal microfluidics, precise temperature control, and AI image recognition, T‐PhaseMap transforms biomolecular condensate phase mapping into a rapid, temperature‐resolved workflow. It generates 3D composition–temperature phase diagrams within 30 min, resolves four phase states, and uncovers temperature‐dependent heparin sodium ...
Jiashuo Li, Pengjie Li, Kaiting Zhang, Yongqi Guo, Peng Chen, Bi‐Feng Liu, Yiwei Li   +6 more
wiley   +1 more source

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

Advanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao, Ting‐Yu Han, Yan‐Li Cheng, Yi‐Dan Zhang, Yu‐Wei Zhang, JinJian Guo, ShaoJun Zhang, WenZe Huang, Jing Zhang, Pei‐Yu Liao, Ying Xin, ChuanChen Chu, Qing‐Yuan Sun, ZhiZhen Liu, Xiang‐Hong Ou, Jun Xie   +15 more
wiley   +1 more source

Firing Properties of EGFP-expressing Granule Cells.

, 2013
The firing properties of EGFP-expressing granule cells in the DCX-EGFP mouse indicate that the cells are at various stages of electrophysiological maturation. A.
Pankaj Sah (158755), Perry F. Bartlett (205720), Jay Spampanato (308959), Robert K. Sullivan (308962), Fabrice R. Turpin (308965)   +4 more
core   +1 more source

Prion‐Like Protein LENG8‐Mediated Nucleation Drives Stress Granule Assembly

Advanced Science, EarlyView.
LENG8 is a newly identified stress granule (SG) nucleator required for SG assembly. Following stress, nuclear LENG8 granules disassemble, allowing LENG8 to translocate into the cytoplasm and form independent nucleation foci. These foci fuse with canonical early G3BP1/TIA1 seeds via LENG8‐TIA1 binding to drive SG maturation.
Mingxing Zhang, Xin Wang, Yilan Teng, Zhicheng Wu, Jing Fan, Hongwen Zhu, Peng Dai   +6 more
wiley   +1 more source

Polymer Concepts in Cellular Function

Advanced Science, EarlyView.
Miao Yu, Shikha Dhiman, Dorothee Dormann, Frauke Gräter, Katja Luck, Friederike Schmid, Andreas Walther, Edward A. Lemke   +7 more
wiley   +1 more source