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Granulocyte Colony-Stimulating Factor [PDF]
, 1990 Granulocyte colony-stimulating factor (G-CSF) is one of the colony-stimulating factors (CSF) which stimulate colony formation from bone marrow cells. Of the four well-known CSFs, G-CSF is the one that specifically regulates proliferation, differentiation, survival, and activation of cells of the restricted neutrophilic granulocyte lineage (Metcalf 1985,
E. Platzer, K. Welte
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Granulocyte Colony-Stimulating Factor
Cancer Investigation, 1989The independent (1,2) establishment of in vitro culture systems for hemopoietic progenitor cells has allowed the identification of various hormones which regulate blood cell production and differentiation. These glycoproteins, known as colony-stimulating factors (CSFs) were originally purified from the conditioned media of a number of diverse sources ...
Larry Souza +2 more
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Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor
New England Journal of Medicine, 1992FOUR colony-stimulating factors influence the survival, proliferation, differentiation, and functional activation of myeloid hematopoietic cells: macrophage colony-stimulating factor (M-CSF), granulocyte colony-stimulating factor (G-CSF), granulocytemacrophage colony-stimulating factor (GM-CSF), and interleukin-3 (formerly known as multi-colony ...
Alastair J.J. Wood +2 more
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[44] Granulocyte colony stimulating factor
1985Granulocyte colony-stimulating factor was discovered during attempts to define the normal regulators present in cell supernatants that could induce terminal differentiation of the murine myeloid leukemic cell line WEHI-3B D+. The purification and subsequent cloning of both murine and human G-CSF allowed the normal functions of this molecule to be ...
Andrew W. Roberts, Nicos A. Nicola
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Granulocyte-Macrophage Colony-Stimulating Factor
Biotherapy, 1990The control of blood cell production is modulated directly or indirectly by more than ten different hematopoietic growth factors (Metcalf 1984). Many names have been assigned to each of the hematopoietic growth factors: although a specific set of names is used throughout this article, the alternative names can be found in other reviews (Nicola and ...
S. Devereux, D. C. Linch
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Granulocyte Colony-Stimulating Factor
Southern Medical Journal, 1993Recombinant human granulocyte colony-stimulating factor (G-CSF) is a nonglycosylated protein produced in Escherichia coli using recombinant DNA technology. G-CSF was first defined in vitro as a relatively selective stimulator of pure granulocyte colonies from normal marrow and as a factor that induces differentiation of leukemic cell lines.
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The Granulocyte-Macrophage Colony-Stimulating Factors
Science, 1985The granulocyte-macrophage colony-stimulating factors are well-characterized specific glycoproteins that interact to control the production, differentiation, and function of two related white cell populations of the blood, the granulocytes and monocyte-macrophages.
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Current Opinion in Hematology, 1995
Hematopoietic growth factors primarily used in patients with acute myelogenous leukemia after chemotherapy could reduce significantly the neutrophil recovery time in all patients. In high-risk acute myelogenous leukemia, trials also reported a reduction in the incidence of documented infections and early mortality rate.
Gernot Seipelt, Dieter Hoelzer
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Hematopoietic growth factors primarily used in patients with acute myelogenous leukemia after chemotherapy could reduce significantly the neutrophil recovery time in all patients. In high-risk acute myelogenous leukemia, trials also reported a reduction in the incidence of documented infections and early mortality rate.
Gernot Seipelt, Dieter Hoelzer
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Granulocyte Colony-Stimulating Factor [PDF]
, 2004 Granulocyte colony-stimulating factor (G-CSF) is a major regulator of the development of antibacterial neutrophilic granulocytic leukocytes (neutrophils). In keeping with the functions of both G-CSF and neutrophils, the murine molecule was first purified from medium that had bathed the dissected lungs of animals previously treated with a bacterial cell-
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Annals of Hematology, 1996
The present study was designed to investigate in vivo immunomodulatory properties of hematopoietic growth factors. The influence on the activation of cytokine synthesis and on the expression of surface antigens associated with cellular activation of G-CSF or GM-CSF was investigated in cancer patients receiving these factors.
U. Haus +9 more
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The present study was designed to investigate in vivo immunomodulatory properties of hematopoietic growth factors. The influence on the activation of cytokine synthesis and on the expression of surface antigens associated with cellular activation of G-CSF or GM-CSF was investigated in cancer patients receiving these factors.
U. Haus +9 more
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