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Granulocyte Colony-Stimulating Factors
2010Despite the first recognition of red cells in the blood by the Dutch scientist Jan Swammerdam around 1658 and the first description of the shape of erythrocytes by his acquaintance Antoni van Leeuwenhoek in 1695, the colorless cellular component of the blood remained unrecognized until 1843.
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Granulocyte Colony-Stimulating Factor
2017Granulocyte colony-stimulating factor (G-CSF) is a potent hematopoietic protein that promotes the development and function of granulocytes and mobilizes stem/progenitor cells from the bone marrow. Recent studies have shown that G-CSF also directly influences the activity of some non-hematopoietic cells, such as cardiomyocytes, endothelial cells, and ...
Atsuhiko Kawamoto, Yasuyuki Fujita
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Granulocyte Colony-stimulating Factor
1998Publisher Summary Granulocyte colony-stimulating factor (G-CSF) is a protein that acts on the neutrophil lineage to stimulate the proliferation, differentiation, and activation of committed progenitor cells and functionally active mature neutrophils.
George Morstyn +4 more
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Cochrane Database of Systematic Reviews, 2006
Colony stimulating factors (CSFs), also called haematopoietic growth factors, regulate bone marrow production of circulating red and white cells, and platelets. Some CSFs also mobilise the release of bone marrow stem cells into the circulation. CSFs have been shown to be neuroprotective in experimental stroke.To assess (1) the safety and efficacy of ...
Timothy J. England +2 more
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Colony stimulating factors (CSFs), also called haematopoietic growth factors, regulate bone marrow production of circulating red and white cells, and platelets. Some CSFs also mobilise the release of bone marrow stem cells into the circulation. CSFs have been shown to be neuroprotective in experimental stroke.To assess (1) the safety and efficacy of ...
Timothy J. England +2 more
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Urinary Granulocyte Colony-Stimulating Factor in Bilharziasis
The American Journal of Tropical Medicine and Hygiene, 1982Studies have been done to determine the levels of human urinary granulocyte colony-stimulating factor in Egyptian patients with active bilharziasis. Colony-stimulating factor levels were measured by a semi-solid tissue culture colony assay with murine bone marrow as the target cell source.
Lotfy A. Mahmoud +2 more
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Current Opinion in Hematology, 1997
The hematopoietic growth factors granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) not only regulate the numbers of circulating neutrophils but also modulate the function of mature cells. Additionally, newly developed neutrophils subsequently released from the bone marrow in response to colony ...
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The hematopoietic growth factors granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) not only regulate the numbers of circulating neutrophils but also modulate the function of mature cells. Additionally, newly developed neutrophils subsequently released from the bone marrow in response to colony ...
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Circular Permutation of Granulocyte Colony-Stimulating Factor
Biochemistry, 1999The sequence of granulocyte colony-stimulating factor (G-CSF) has been circularly permuted by introducing new chain termini into interhelical loops and by constraining the N- and C-terminal helices, either by direct linkage of the termini (L0) or by substitution of the amino-terminal 10-residue segment with a seven-residue linker composed of glycines ...
Linda L. Zurfluh +10 more
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Granulocyte-Macrophage Colony-Stimulating Factor in Psoriasis
Dermatology, 1990Granulocyte-macrophage colony-stimulating factor (GM-CSF), a product of activated T lymphocytes, macrophages, endothelial cells, fibroblasts, and keratinocytes, is thought to play an important role in inflammatory reactions by ‘priming’ or enhancing the functions of neutrophils and macrophages.
H. Takematsu, Hachiro Tagami
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Functions of Granulocyte-Macrophage Colony-Stimulating Factor
Critical Reviews in Immunology, 2005GM-CSF was originally defined by its ability to generate in vitro granulocyte and macrophage colonies from bone marrow precursor cells. Apart from its physiological role in the control of alveolar macrophage development, it now appears more likely that its major role lies in its ability to govern the properties of the more mature myeloid cells of the ...
Andrew J. Fleetwood +2 more
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Effect of Colony-Stimulating Factors on Granulocyte Function
1993Phagocytes including polymorphonuclear neutrophils (PMN), monocytes, macrophages, and eosinophils are essential for host defense against certain microbes and probably play an important role in the surveillance and destruction of neoplastic cells. The production, maturation, and function of these cells appear to be regulated in a very complex manner by ...
K. Vollmer, G. L. Mandell
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