Results 61 to 70 of about 4,929,218 (260)

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

The role of PLAU in polycystic ovary syndrome: activation of STAT3-mediated NLRP3 signaling to promote granulosa cell injury, inflammation, and apoptosis

Applied Biological Chemistry
Background Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder. Granulosa cell dysfunction is an important factor causing PCOS.PLAU has been shown to be upregulated in granulosa cells of PCOS patients, but its potential ...
Penghua Luo, Canyi Li, Lin Tang, Yongqiang Yang, Long Rao, Xiguang Mao, Lijun Zhong   +6 more
doaj   +1 more source

Adult Granulosa cell tumor: A small mass producing troublesome morbidity to a woman

Journal of Bahria University Medical and Dental College, 2018
: Granulosa cell tumors are sex-cord stromal tumor ofovary, a rare neoplasmaccounting for approximately 3-5% of all ovarian malignancies. Hormone producing tumor, a total of 95% of all GCTs are adult type and of large size.
Khalida Nasreen, Samreen Iqbal
doaj   +1 more source

Large-scale DNA demethylation occurs in proliferating ovarian granulosa cells during mouse follicular development

Communications Biology, 2021
Tomoko Kawai et al. investigate DNA methylation patterns during granulosa cell differentiation and proliferation. Their results suggest that sequential epigenetic events are essential for progressive changes in granulosa cell differentiation.
Tomoko Kawai, JoAnne S. Richards, Masayuki Shimada   +2 more
doaj   +1 more source

Modification of the Transcription Factor FOXL2 at Serines 101 and 107 Disables DNA Binding, Leads to Nucleolar Relocalization, and Rewires Granulosa-Cell Programs. [PDF]

FASEB J
PKC‐mediated phosphorylation of FOXL2 weakens DNA binding, alters subnuclear localization and protein interactions, and reshapes FOXL2‐dependent transcriptional programs in granulosa cells, supporting a reversible mechanism that modulates FOXL2 activity through phosphorylation of its DNA‐binding domain. ABSTRACT FOXL2 is a forkhead transcription factor
Mousseron L, Chousianiti D, Poulat F, Legois B, Veitia RA, Todeschini AL.   +5 more
europepmc   +2 more sources

Larval and early juvenile development of Paralomis granulosa reared at different temperatures: tolerance of cold and food limitation in a lithodid crab from high latitudes [PDF]

, 2003
Paralomis granulosa Jacquinot is a commercially fished lithodid crab species living in subantarctic and cold-temperate regions of southern South America.
Lovrich, G., Thatje, S., Calcagno, J.A., Anger, Klaus, Lovrich, Gustavo Alejandro, Lovrich, G.A., Calcagno, J., Anger, K.   +7 more
core   +1 more source

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

Downregulating lncRNA NEAT1 induces proliferation and represses apoptosis of ovarian granulosa cells in polycystic ovary syndrome via microRNA-381/IGF1 axis

Journal of Biomedical Science, 2021
Objective Researchers have revealed the combined functions of long noncoding RNAs (lncRNAs) and microRNA (miRNAs) in polycystic ovary syndrome (PCOS). This study aimed to understand the role of nuclear-enriched abundant transcript 1 (NEAT1) and miR-381 ...
Jingran Zhen, Jiangli Li, Xia Li, Xue Wang, Yaling Xiao, Zhengyi Sun, Qi Yu   +6 more
doaj   +1 more source

Dietary Glutamine Supplementation Alleviated Rumen Epithelium Oxidative Damage and Apoptosis Induced by Feed Restriction via Maintaining Mitochondrial Homeostasis in Female Yaks

Animal Research and One Health, EarlyView.
Dietary glutamine (Gln) supplementation increased the ATP levels and promoted cell proliferation in the rumen epithelium of feed‐restricted yaks. Besides, Gln inhibited ROS accumulation and reduced oxidative damage and apoptosis in the rumen epithelium of feed‐restricted yaks.
Ziqi Yue, Shanpeng Ke, Liyuan Shi, Rui Hu, Zhisheng Wang, Quanhui Peng, Huawei Zou, Jianxin Xiao, Yahui Jiang, Fali Wu, Yiping Tang   +10 more
wiley   +1 more source

Homeobox A7 increases cell proliferation by up-regulation of epidermal growth factor receptor expression in human granulosa cells

Reproductive Biology and Endocrinology, 2010
Background Homeobox (HOX) genes encode transcription factors, which regulate cell proliferation, differentiation, adhesion, and migration. The deregulation of HOX genes is frequently associated with human reproductive system disorders. However, knowledge
Yanase Toshihiko, Nishi Yoshihiro, Cheng Jung-Chien, Huang Qing, Zhang Yu, Huang He-Feng, Leung Peter CK   +6 more
doaj   +1 more source