Results 71 to 80 of about 65,963 (206)

Overexpression of CDC25C affects the cell cycle of ovarian granulosa cells from adult and young goats

Electronic Journal of Biotechnology, 2018
Background: CDC25 is a dual-specificity phosphatase that was first identified in the yeast Schizosaccharomyces pombe as a cell cycle-defective mutant. Although CDC25 is involved in the cell cycle of ovarian granulosa cells, the CDC25 signaling pathway ...
Haiyan Guo, Qiang Wang, Yongjun Li, Xiuyuan Yin, Hao Zhang, Jianfei Shi   +5 more
doaj   +1 more source

Extraordinarily Prolonged Disease Recurrence in a Granulosa Cell Tumor Patient

Case Reports in Oncology, 2010
Background: Granulosa cell tumors are rare sex cord stromal lesions that comprise approximately 3% of all ovarian neoplasms. The vast majority of granulosa cell tumors are considered indolent but in spite of aggressive management, delayed recurrence is ...
Lisa N. Abaid, Monica Mosquera-Caro, Rita C. Kankus, Bram H. Goldstein   +3 more
doaj   +1 more source

Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ. [PDF]

, 2014
We previously identified FOXL2 as a critical component in FSHβ gene transcription. Here, we show that mice deficient in FOXL2 have lower levels of gonadotropin gene expression and fewer LH- and FSH-containing cells, but the same level of other pituitary ...
Barakat, Nermeen H, Breen, Kellie M, Coss, Djurdjica, Hambarchyan, Arpi, Meadows, Jason D, Mellon, Pamela L, Pepa, Patricia A, Roybal, Lacey L   +7 more
core   +1 more source

A multi-exon deletion within WWOX is associated with a 46,XY disorder of sex development [PDF]

, 2011
Disorders of sex development (DSD) are congenital conditions where chromosomal, gonad or genital development is atypical. In a significant proportion of 46,XY DSD cases it is not possible to identify a causative mutation, making genetic counseling ...
AJ Notini, AJ Paige, AK Bednarek, Andrew Sinclair, D Wilhelm, DM Maatouk, E Sutton, Erin Turbitt, H Stoop, Jacqueline Hewitt, JH Ludes-Meyers, Leendert Looijenga, LH Looijenga, M Cools, M Cools, Martine Cools, MI Nunez, N Bouteille, PA Lee, Peter Koopman, R Hersmus, Remko Hersmus, RI Aqeilan, RI Aqeilan, RI Aqeilan, RI Aqeilan, S Del Mare, SJ White, SJ White, Stefan White, Stenvert Drop, Vincent Harley, Yvonne van der Zwan   +32 more
core   +1 more source

Acupuncture regulates the apoptosis of ovarian granulosa cells in polycystic ovarian syndrome-related abnormal follicular development through LncMEG3-mediated inhibition of miR-21-3p

Biological Research, 2023
Background The main features of polycystic ovary syndrome (PCOS) are abnormal follicular development and ovulatory dysfunction, which are caused by excessive apoptosis of ovarian granulosa cells.
Xiaohong Chen, Hengzhen He, Bingcai Long, Binli Wei, Peng Yang, Xiaoying Huang, Qian Wang, Jing Lin, Hongliang Tang   +8 more
doaj   +1 more source

Expression of the DNA mismatch repair proteins hMLH1 and hPMS2 in normal human tissues. [PDF]

, 1997
hMLH1 and hPMS2 are part of the DNA mismatch repair complex. Mutations in these genes have been linked to hereditary non-polyposis colon cancer; they also occur in a variety of sporadic cancers. Western blot analysis and immunohistochemistry demonstrated
Aebi, S, Christen, RD, Fink, D, Howell, SB, Kim, HK, Nebel, S, Zheng, H   +6 more
core   +1 more source

Autophagy-disrupted LC3 abundance leads to death of supporting cells of human oocytes

Biochemistry and Biophysics Reports, 2018
Autophagic recycling of cell parts is generally termed as the opposite of cell death. Here, we explored the relation between cell death and autophagy by examining granulosa cell layers that control oocyte quality, which is important for the success of ...
Woojin Kang, Eri Ishida, Kenji Yamatoya, Akihiro Nakamura, Mami Miyado, Yoshitaka Miyamoto, Maki Iwai, Kuniko Tatsumi, Takakazu Saito, Kazuki Saito, Natsuko Kawano, Toshio Hamatani, Akihiro Umezawa, Kenji Miyado, Hidekazu Saito   +14 more
doaj   +1 more source

Adult granulosa cell tumor associated with endometrial carcinoma: a case report [PDF]

, 2011
Introduction If strict criteria for the diagnosis of carcinoma are used and all patients with granulosa cell tumors are considered, the best estimate of the incidence of associated endometrial carcinomas is under 5%.
Cornelius O Ukah, Okechukwu C Ikpeze, George U Eleje, Ahizechukwu C Eke   +3 more
core   +1 more source

Intrinsic differences in mTOR activity mediates lineage-specific responses to cyclophosphamide in mouse and human granulosa cells

Journal of Ovarian Research
Background Cyclophosphamide (CTX) often induces oocyte and granulosa cell injury, leading to fertility loss in young female cancer survivors. Deciphering the mechanisms underlying follicular cell injury could offer novel insights into fertility ...
Shiqian Xu, Yerong Ma, Yinli Zhang, Hanqi Ying, Xiaomei Tong, Weijie Yang, Yibin Pan, Yan Rong, Yangyang Dai, Songying Zhang, Peidong Han   +10 more
doaj   +1 more source

Granulosa cell tumor of the ovary: a clinicopathological study of six cases

Journal of Pathology of Nepal, 2011
Background: Ovarian granulosa cell tumors are rare malignant neoplasms that originate from the sexcord stromal cells of the ovary. The study aims to collate data of all granulosa cell tumors diagnosed in Tribhuvan University Teaching Hospital over the ...
RC Adhikari, A Jha, G Shayami
doaj   +1 more source