Results 71 to 80 of about 10,360,699 (193)

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

The Influence Of Kesambi Leaf Extract (Schleichera oleosa) On Proliferation Granulosa Cell Goat Ovarium (Caprus aegagrus HIRCUS) In Vitro

Jurnal Biota, 2020
Kesambi (Schleichera oleosa) belonging to the Sapindaceae family has very important phytochemical elements including terpenoids, falvonoids, phenolic acids, betulins, betulin acids and others, so that they have enormous benefits in the process of ...
Lil Hanifah
doaj   +1 more source

Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation

Nature Communications, 2021
Uncoupling of mature oocytes from somatic granulosa cells is required for their fertilization. Here the authors show that activation of EGFR signalling in granulosa cells during ovulation triggers ERK-dependent loss of filopodia oocyte adhesion, and Arp2/
Laleh Abbassi, Stephany El-Hayek, Karen Freire Carvalho, Wusu Wang, Qin Yang, Sofia Granados-Aparici, Rafael Mondadori, Vilceu Bordignon, Hugh J. Clarke   +8 more
doaj   +1 more source

FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development.

Molecular Endocrinology, 2015
The forkhead box (FOX), FOXO1 and FOXO3, transcription factors regulate multiple functions in mammalian cells. Selective inactivation of the Foxo1 and Foxo3 genes in murine ovarian granulosa cells severely impairs follicular development and apoptosis ...
Zhilin Liu, Y. Ren, S. Pangas, Jaye E Adams, W. Zhou, D. Castrillon, D. Wilhelm, J. Richards   +7 more
semanticscholar   +1 more source

The mitochondrial DNA copy number and ovary‐related reproductive disorders: A bidirectional two‐sample Mendelian randomization study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 112-120, April 2025.
Abstract Objective In the present study, a bidirectional two‐sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA‐CN) and ovary‐related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian ...
Ke Peng, Xiao Han, Congquan Wu, Qiaowen Lu, Shujun Gao   +4 more
wiley   +1 more source

Ameliorative Effect of Itaconic Acid/IRG1 Against Endoplasmic Reticulum Stress-Induced Necroptosis in Granulosa Cells via PERK-ATF4-AChE Pathway in Bovine

Cells
The necroptosis of granulosa cells has been proven to be one of the important triggers of follicular atresia, which is an important cause of reduced reproductive capacity in cows.
Xiaorui Yang, Yue Chen, Xinzi Wang, Gaoqing Xu, Hongjie Wang, Xinqi Shu, He Ding, Xin Ma, Jing Guo, Jun Wang, Jing Zhao, Yi Fang, Hongyu Liu, Wenfa Lu   +13 more
doaj   +1 more source

The LINC00477/miR-128 axis promotes the progression of polycystic ovary syndrome by regulating ovarian granulosa cell proliferation and apoptosis

Reproductive Biology and Endocrinology, 2021
Background Long noncoding RNAs (lncRNAs) participate in the pathogenesis of various human diseases. This study aims to investigate the roles of lncRNA LINC00477 in polycystic ovary syndrome (PCOS), especially the impacts of LINC00477 on the proliferation
Haijie Gao, Jinna Jiang, Yingying Shi, Jiying Chen, Lijian Zhao, Chenhong Wang   +5 more
doaj   +1 more source

The correlation between ANAs and pregnancy loss and their impact on IVF/ICSI‐ET pregnancy outcomes in patients with recurrent pregnancy loss

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To explore the correlation between antinuclear antibodies (ANAs) and pregnancy loss (PL), and to observe its impact on the pregnancy outcomes of in vitro fertilization/intracytoplasmic sperm injection‐embryo transfer (IVF/ICSI‐ET) in recurrent PL (RPL) patients. Methods In this retrospective study, patients first seen at the hospital
Manman Liu, Hebo Zhang, Shilian Xu, Rui Zhang, Mengfan Yuan, Bingnan Ren, Wenjuan Zhang, Zhaozhao Liu, Yichun Guan   +8 more
wiley   +1 more source

Protective effect of luteinizing hormone on frozen-thawed ovarian follicles and granulosa cells.

PLoS ONE
Ovarian tissue cryopreservation addresses critical challenges in fertility preservation for prepubertal female cancer patients, such as the lack of viable eggs and hormonal deficiencies.
Jie Chen, Boyang Yu, Shengbo Zhang, Zhikang Wang, Yanfeng Dai   +4 more
doaj   +1 more source

Genetic association between microRNA gene polymorphisms and polycystic ovary syndrome susceptibility: A systematic review and meta‐analysis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age, associated with genetic and environmental factors, including microRNA (miRNA) gene polymorphisms. Objective To evaluate the association between miRNA gene polymorphisms and PCOS. Search Strategy PubMed, Embase, Web of Science, and Scopus
Amaxsell Thiago Barros de Souza, Ketelly Leônara da Silva Torres, Ayane Cristine Alves Sarmento, Ariadne Sarynne Barbosa de Lima, Kleyton Santos de Medeiros, Deyse de Souza Dantas, Ricardo Ney Cobucci, Ana Katherine Gonçalves, Janaina Cristiana de Oliveira Crispim   +8 more
wiley   +1 more source