Results 11 to 20 of about 78,948 (301)
Fish Granzyme A Shows a Greater Role Than Granzyme B in Fish Innate Cell-Mediated Cytotoxicity [PDF]
Frontiers in Immunology, 2019 Granzymes (Gzm) are serine proteases, contained into the secretory granules of cytotoxic cells, responsible for the cell-mediated cytotoxicity (CMC) against tumor cells and intracellular pathogens such as virus and bacteria.
Elena Chaves-Pozo +8 more
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Granzyme A in Chikungunya and Other Arboviral Infections [PDF]
Frontiers in Immunology, 2020 Granzyme A (GzmA) is secreted by cytotoxic lymphocytes and has traditionally been viewed as a mediator of cell death. However, a growing body of data suggests the physiological role of GzmA is promotion of inflammation.
Alessandra S. Schanoski +16 more
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Granzyme B; the chalk-mark of a cytotoxic lymphocyte [PDF]
Journal of Translational Medicine, 2004 During cytotoxic lymphocyte (CL) mediated killing of target cells, granzyme B is released from the CL into the immune synapse. Recent studies have found that ELISPOT-detection of granzyme B correlated well with conventional assays for CL mediated killing.
Clarke Chris JP +2 more
doaj +3 more sources
Journal of Cell Science, 2006 Defence against virally infected and malignant cells depends on the action of cytotoxic T lymphocytes and natural killer cells ([Barry and Bleackley, 2002][1]; [Russell and Ley, 2002][2]). Although these use several mechanisms to eliminate target cells, the principal event is secretion of ...
Bots, Michael, Medema, Jan Paul
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A quarter century of granzymes [PDF]
Cell Death & Differentiation, 2011 Granzymes (Grs) were discovered just over a quarter century ago. They are produced by cytotoxic T cells and natural killer cells and are released upon interaction with target cells. Intensive biochemical, genetic, and biological studies have been performed in order to study their roles in immunity and inflammation.
C L, Ewen, K P, Kane, R C, Bleackley
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Perforin and granzyme B have separate and distinct roles during atherosclerotic plaque development in apolipoprotein E knockout mice. [PDF]
PLoS ONE, 2013 The granzyme B/perforincytotoxic pathway is a well established mechanism of initiating target cell apoptosis. Previous studies have suggested a role for the granzyme B/perforin cytotoxic pathway in vulnerable atherosclerotic plaque formation.
Paul R Hiebert +4 more
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Residual Cytotoxicity and Granzyme K Expression in Granzyme A-deficient Cytotoxic Lymphocytes [PDF]
Journal of Biological Chemistry, 1997 Cytotoxic lymphocytes contain granules that have the ability to induce apoptosis in susceptible target cells. The granule contents include perforin, a pore-forming molecule, and several granzymes, including A and B, which are the most abundant serine proteases in these granules. Granzyme B-deficient cytotoxic T lymphocytes (CTL) have a severe defect in
S, Shresta +3 more
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Mucosal-associated invariant T cells in patients with axial spondyloarthritis
Frontiers in Immunology, 2023 BackgroundSeveral studies implicate Th17-cells and its cytokine (IL-17) in disease pathogenesis of spondyloarthritis (SpA), with available evidence supporting a pathogenic role of CD8+ T-cells.
Rienk Gerben van der Meer +7 more
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A novel proinflammatory role for granzyme A [PDF]
Cell Death & Disease, 2017 Granzymes are a family of homologous serine proteases involved in inducing apoptosis in virus-infected cells and tumor cells.1, 2 In humans, five granzymes (GrA, GrB, GrH, GrK, and GrM) are expressed, and stored in granules of natural killer (NK) cells, NK-T cells, cytotoxic T cells, and γδ T cells, which are collectively referred to as cytotoxic ...
Van Eck, Jacqueline A. +4 more
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Granzyme A Is Expressed in Mouse Lungs during Mycobacterium tuberculosis Infection but Does Not Contribute to Protection In Vivo. [PDF]
PLoS ONE, 2016 Granzyme A, a serine protease expressed in the granules of cytotoxic T and Natural Killer cells, is involved in the generation of pro-inflammatory cytokines by macrophages. Granzyme A has been described to induce in macrophages in vitro the activation of
Santiago Uranga +4 more
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