Results 21 to 30 of about 53,159 (257)
Frontiers in Immunology, 2021 Natural Killer (NK) cells are cytotoxic lymphocytes critical to the innate immune system. We found that germline deficiency of NF-κB c-Rel results in a marked decrease in cytotoxic function of NK cells, both in vitro and in vivo, with no significant ...
Yorleny Vicioso +8 more
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Targeted Cell-to-Cell Delivery of Protein Payloads via the Granzyme-Perforin Pathway
Molecular Therapy: Methods & Clinical Development, 2017 There is great potential for engineering cellular therapeutics by repurposing biological systems. Here, we report utilization of the granzyme-perforin pathway of cytotoxic lymphocytes as a cell-to-cell protein delivery module. We designed and constructed
Daniel J. Woodsworth +3 more
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Granzyme B Attenuates Bacterial Virulence by Targeting Secreted Factors
iScience, 2020 Summary: Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to ...
Diego López León +7 more
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Granzymes in cancer and immunity [PDF]
Cell Death & Differentiation, 2010 Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells are indispensable factors in the body's ongoing defence against viral infection and tumor development. CTL/NK cells recognize and kill infected or aberrant target cells by two major pathways: either through introduction of a battery of proteases - called granzymes - to the target cell cytosol,
S P, Cullen, M, Brunet, S J, Martin
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A quarter century of granzymes [PDF]
Cell Death & Differentiation, 2011 Granzymes (Grs) were discovered just over a quarter century ago. They are produced by cytotoxic T cells and natural killer cells and are released upon interaction with target cells. Intensive biochemical, genetic, and biological studies have been performed in order to study their roles in immunity and inflammation.
C L, Ewen, K P, Kane, R C, Bleackley
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Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution. [PDF]
PLoS ONE, 2016 Granzyme B is one of the key effector molecules in our defense against viruses and intracellular bacteria. This serine protease together with the pore forming protein perforin, induces caspase or Bid-dependent apoptosis in target cells.
Zhirong Fu +3 more
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Control of granzymes by serpins [PDF]
Cell Death & Differentiation, 2009 Although proteolysis mediated by granzymes has an important role in the immune response to infection or tumours, unrestrained granzyme activity may damage normal cells. In this review, we discuss the role of serpins within the immune system, as specific regulators of granzymes. The well-characterised human granzyme B-SERPINB9 interaction highlights the
D, Kaiserman, P I, Bird
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Granzymes—Their Role in Colorectal Cancer
International Journal of Molecular Sciences, 2022 Colorectal cancer (CRC) is among the most common malignancies worldwide. CRC is considered a heterogeneous disease due to various clinical symptoms, biological behaviours, and a variety of mutations. A number of studies demonstrate that as many as 50% of CRC patients have distant metastases at the time of diagnosis.
Sara Pączek +2 more
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Expression of intra- and extracellular granzymes in patients with typhoid fever.
PLoS Neglected Tropical Diseases, 2017 BackgroundTyphoid fever, caused by the intracellular pathogen Salmonella (S.) enterica serovar Typhi, remains a major cause of morbidity and mortality worldwide.
Hanna K de Jong +8 more
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Comprehensive Analysis of Granzymes and Perforin Family Genes in Multiple Cancers
BiomedicinesBackground/Objectives: Cancer remains a significant global health concern, with immunotherapies emerging as promising treatments. This study explored the role of perforin-1 (PRF1) and granzymes A, B and K (GZMA, GZMB and GZMK) in cancer biology, focusing
Manvita Mareboina +5 more
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