Results 221 to 230 of about 78,948 (301)

Programmable Antigen‐Specific Immunity via Self‐Adjuvanting Nanovaccines Co‐Delivering Immune Modulators

Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.
The self‐adjuvanting vaccine—comprising a covalent conjugate of antigen and adjuvant—was formulated into cationic lipid nanoparticles smaller than 100 nm to facilitate uptake by immune cells, with supplemental adjuvants incorporated to modulate immune responses.
Keita Ito, Yoshiyuki Manabe, Shino Ohshima, Masatoshi Maeki, Manabu Tokeshi, Hiroshi Inaba, Kazunori Matsuura, Kazuya Kabayama, Yoshie Kametani, Koichi Fukase   +9 more
wiley   +2 more sources

The mechanism regulating the cytotoxicity of γδ T cells activated by mycobacterium tuberculosis heat-resistant antigen based on RNA-seq analysis. [PDF]

Front Immunol
Song Y, Guo F, Dai H, Zhou X, Dong S, Zhang H, Qian Z, Li B, Wang X, Xu T, Wang H.   +10 more
europepmc   +1 more source

Dynamic T‐Cell Reprogramming Modulates the Treatment Outcome of Neoadjuvant Immunochemotherapy in Non‐Small‐Cell Lung Cancer

MedComm, Volume 7, Issue 4, April 2026.
We explored the responding mechanisms associated with pathological responsiveness to neoadjuvant immunochemotherapy. CD8+ T‐cell subsets, including effect memory T (Tem), effector T (Teff), resident memory T (Trm), as well as exhausted T cells (Tex), showed higher clonality and diversity in responders, and both novel and pre‐existing clonal expansion ...
Rui Jin, Anhao Tian, Weina Lu, Qiyuan Wang, Xiuzhen Li, Sai Zhang, Guanxin Xu, Kai Zhu, Peng Li, Jianan Li, Wei Chen, Weiwei Yin, Wen Li, Yang Xia   +13 more
wiley   +1 more source

Granzyme B-producing B cells: a bidirectional relationship with breast cancer cells and implications for immunotherapy. [PDF]

Am J Clin Exp Immunol
Hakimi H, Mehdipour F, Samadi M, Balouchi Anaraki S, Rasolmali R, Talei AR, Ghaderi A.   +6 more
europepmc   +1 more source

<i>Epimedium brevicornu</i> Maxim. extract activates natural killer cells against hepatocellular carcinoma via the cGAS-STING pathway. [PDF]

Front Pharmacol
Liu L, Zhan X, Wang X, Wen J, He C, Chen X, Guo Y, Wang X, Li L, Cheng H, Bai Z, Xiao X.   +11 more
europepmc   +1 more source

C‐X‐C chemokine receptor CXCR4 mediates diurnal changes in the aggregation and dispersion of CD8+ T cells within the tumor microenvironment

International Journal of Cancer, Volume 158, Issue 6, Page 1740-1754, 15 March 2026.
What's new? In addition to governing daily variations in biological activity, the circadian clock regulates immune cell migration into tumors. Whether this influence extends to immune cell localization within the tumor microenvironment (TME) is unknown. Here, using cell and animal models, the authors investigated immune cell distribution within the TME
Akito Tsuruta, Marina Fujimoto, Yasuha Hiraoka, Aoi Taniguchi, Yuki Shiiba, Takuto Inoki, Tomoaki Yamauchi, Yuya Yoshida, Naoya Matsunaga, Shigehiro Ohdo, Satoru Koyanagi   +10 more
wiley   +1 more source

Cytotoxic CD4⁺ T cells: origin, biological functions, diseases and therapeutic targets. [PDF]

Signal Transduct Target Ther
Lai L, Ran S, Li Y, Cui J, Zhang X, Yu J, Zou Y, Zhou C, Xia J, Wu J.   +9 more
europepmc   +1 more source

Quinovic Acid Enhances the Cytotoxicity of KHYG-1 Cells by Modulating the Ras/MAPK Signalling Pathway and Interferon-Gamma Expression. [PDF]

J Cell Mol Med
Hsieh MJ, Lin JT, Chuang YC, Ho HY, Lo YS, Lin CC, Chen MK.   +6 more
europepmc   +1 more source

Intradermal immunization with Plasmodium berghei late-arresting genetically attenuated sporozoites induces PD-L1 expression on regulatory macrophages and dendritic cells. [PDF]

Sci Rep
van Schuijlenburg R, Naar CM, de Bes-Roeleveld HM, Chevalley-Maurel S, Zigó LA, Houlder EL, Lambooij JM, Baalbergen E, Roestenberg M, Franke-Fayard B.   +9 more
europepmc   +1 more source