Results 201 to 210 of about 53,159 (257)

Indole-3-acetic acid derived from <i>Blautia</i> protects against sepsis-induced acute lung injury. [PDF]

Front Immunol
Chao K, Ding Y, Ji W, Wang D, Liang Q, Sun S, Li L, Yang H, Zhao J.   +8 more
europepmc   +1 more source

Indole‐3‐Propionic Acid Drives Dendritic H3K27 Acetylation to Enhance CD8+ T Cell Immunity in Hepatocellular Carcinoma

Cancer Science, EarlyView.
The gut microbiota metabolite indole ‐ 3 ‐ propionic acid（IPA) enhanced the inhibitory effect of SCB on tumor growth in HCC mice. IPA upregulated IL‐12A expression through facilitating acetylation of H3K27 in DCs. IPA elevated IL‐12A expression in DCs to promote CD8+ T cell anti‐tumor immunity and ultimately enhances the efficacy of SCB therapy against
Rui Zhao, Siqi Liu, Qian Zhang, Wenrui Wang, Lanlan Yang, Xue Shao, Shengnan Jia, Zhenjing Jin   +7 more
wiley   +1 more source

Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2-deficient environments. [PDF]

J Exp Med
Blanco-Domínguez R, Vaz-Pinto AM, Barros L, Lopes N, Henriques-Alves B, Carreira M, Labão-Almeida C, Ribot JC, Bernardes GJL, Silva-Santos B, Mensurado S.   +10 more
europepmc   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Overactivation of Cdc42 GTPase Impairs the Cytotoxic Function of NK Cells From Old Individuals Towards Senescent Fibroblasts. [PDF]

Aging Cell
Koroma AK, Singh K, Wang Y, Krug L, Haas P, Wlaschek M, Sakk V, Schuster T, Fürst D, Schrezenmeier H, Dheenadayalan RP, Stilgenbauer S, Walter L, Geiger H, Scharffetter-Kochanek K, Maity P.   +15 more
europepmc   +1 more source

Constitutively Active Stat5b Expression in Dendritic Cells Enhances Treg-Mediated Elimination of Autoreactive CD8⁺ T Cells in Autoimmune Diabetes. [PDF]

Int J Mol Sci
Khongorzul P, Khan FU, Levasseur D, Gris D, Amrani A.   +4 more
europepmc   +1 more source

Restoration of Mucosa-Associated Invariant T-Cell Function in Healthcare-Associated Bacterial Infections Supports Recovery of Carbapenem Efficacy Against Resistant Bacteria Ex Vivo. [PDF]

J Infect Dis
Xue Y, Karim AM, Sia WR, Han F, Chan KL, Chua NG, Hadadi L, Liu Z, Mak JYW, Fairlie DP, Wang LF, Sandberg JK, Kwa AL, Leeansyah E.   +13 more
europepmc   +1 more source

Comparative proteome analyses of human natural killer cells from patients after allogeneic stem cell transplantation and healthy individuals challenged with <i>Aspergillus fumigatus</i>. [PDF]

Microlife
Springer J, Drobny M, Heilig L, Kraus S, Kniemeyer O, Krüger T, Olischer C, Bussemer L, Panagiotou G, Brakhage AA, Einsele H, Schäuble S, Löffler J.   +12 more
europepmc   +1 more source

Cytomegalovirus-Specific T Cell Immunity and Clinical Associations in Patients With CMV Anterior Uveitis. [PDF]

Invest Ophthalmol Vis Sci
Hsu YR, Gao CM, Chin WY, Miaw SC, Wang IJ, Su CC.   +5 more
europepmc   +1 more source

Extracellular granzyme K enhances PD-L1 transcription and stability via F2RL1 activation to facilitate tumor immune evasion in lung adenocarcinoma. [PDF]

J Immunother Cancer
Feng HM, Zhao Y, Zhai KR, Li B, Song TN, Meng YQ, Huang HR, Li Z, Cui BQ, Yang N, Su ZP.   +10 more
europepmc   +1 more source