Results 61 to 70 of about 250,057 (298)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

In-Memory Caching for Enhancing Subgraph Accessibility

Applied Sciences, 2020
Graphs have been utilized in various fields because of the development of social media and mobile devices. Various studies have also been conducted on caching techniques to reduce input and output costs when processing a large amount of graph data.
Kyoungsoo Bok, Seunghun Yoo, Dojin Choi, Jongtae Lim, Jaesoo Yoo   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Firmware Attestation in IoT Swarms Using Relational Graph Neural Networks and Static Random Access Memory

AI
The proliferation of Internet of Things (IoT) swarms—comprising billions of low-end interconnected embedded devices—has transformed industrial automation, smart homes, and agriculture.
Abdelkabir Rouagubi, Chaymae El Youssofi, Khalid Chougdali   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Decidability of Safety in Graph-based Models for Access Control

, 2002
Models of Access Control Policies specified with graphs and graph transformation rules combine an intuitive visual representation with solid semantical foundations.
Manuel Koch, MANCINI, Luigi Vincenzo, Luigi V. Mancini, Francesco Parisi-Presicce, PARISI PRESICCE, Francesco, M. KOCH   +5 more
core   +1 more source

Graph-Assisted Bayesian Node Classifiers

, 2023
Many datasets can be represented by attributed graphs on which classification methods may be of interest. The problem of node classification has attracted the attention of scholars due to its wide range of applications. The problem consists of predicting
Hafidi, Hakim, Ananthram Swami, Ciblat, Philippe, Mounir Ghogho, Ghogho, Mounir, Hakim Hafidi, Philippe Ciblat, Swami, Ananthram   +7 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

GOLEM: an interactive graph-based gene-ontology navigation and analysis tool

BMC Bioinformatics, 2006
Background The Gene Ontology has become an extremely useful tool for the analysis of genomic data and structuring of biological knowledge. Several excellent software tools for navigating the gene ontology have been developed.
Huttenhower Curtis, Hibbs Matthew A, Sealfon Rachel SG, Myers Chad L, Troyanskaya Olga G   +4 more
doaj   +1 more source