Results 71 to 80 of about 250,057 (298)

Recombination and population structure in salmonella enterica [PDF]

, 2011
Salmonella enterica is a bacterial pathogen that causes enteric fever and gastroenteritis in humans and animals. Although its population structure was long described as clonal, based on high linkage disequilibrium between loci typed by enzyme ...
Street, T, Bowden, R., Anjum, Muna F., Xavier Didelot, Falush Daniel, Donnelly Peter, Didelot, X., Anjum, MF, Donelly, P., McVean, G., Gil McVean, Vartul Sangal, Didelot, X, Bowden, Rory, Anjum Muna F., Donnelly, Peter, Anjum, Muna, Achtman, Mark, Sangal, V, Spencer, C., Falush, Daniel, Muna F. Anjum, Sangal, V., Tanya Golubchik, Anjum, M., Achtman, M., Daniel Falush, Peter Donnelly, McVean, G, Didelot, Xavier, Teresa Street, Mark Achtman, Bowden Rory, Spencer, Chris, Didelot Xavier, Sangal, Vartul, Street, T., Spencer Chris, McVean Gil, Spencer, C, Donelly, Peter, Chris Spencer, Donnelly, P, Street, Teresa, Street Teresa, Golubchik Tanya, Golubchik, T., Achtman Mark, Golubchik, Tanya, Falush, D, Rory Bowden, Bowden, R, McVean, Gilean, Sangal Vartul, McVean, Gil, Golubchik, T, Falush, D. ; https://orcid.org/, Muna F Anjum, Achtman, M   +58 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Graph Access Pattern Diagrams (GAP-D): Towards a Unified Approach for Modeling Navigation over Hierarchical, Linear and Networked Structures [PDF]

, 2012
In this paper we motivate the advantages of a unified, language-independent concept for describing and defining navigation systems based on underlying graph structures. We expect that such an approach will lower the effort for implementing navigation systems with application frameworks while increasing the configurability and reusability of navigation ...
Matthias Keller, Martin Nussbaumer
openaire   +2 more sources

Graph Pattern Matching: From Intractable to Polynomial Time

, 2010
Graph pattern matching is typically defined in terms of sub-graph isomorphism, which makes it an np-complete problem. Moreover, it requires bijective functions, which are often too restrictive to characterize patterns in emerging applications. We propose
Li, Jianzhong, Tang, Nan, Ma, Shuai, Fan, Wenfei; id_orcid, Wu, Yunpeng, Wu, Yinghui   +5 more
core  

Visualising the structure of document search results: A comparison of graph theoretic approaches

, 2010
This is the post-print of the article - Copyright @ 2010 Sage PublicationsPrevious work has shown that distance-similarity visualisation or ‘spatialisation’ can provide a potentially useful context in which to browse the results of a query search ...
Cribbin, T
core   +1 more source

i-Dataquest: A heterogeneous information retrieval tool using data graph for the manufacturing industry [PDF]

, 2023
Manufacturing industry needs access to the data in order to realise its activities but also to generate new value-added knowledge. Nevertheless, it is confronted with a large and growing volume of heterogeneous data which limits its ability to exploit ...
YAHIA, Esma, SEGONDS, Frederic, MALLET, Antoine, KIM, Lise, VÉRON, Philippe   +4 more
core  

COMBINATORIAL ALGORITHMS FOR GRAPH DISCOVERY AND EXPERIMENTAL DESIGN

, 2022
In this thesis, we study the design and analysis of algorithms for discovering the structure and properties of an unknown graph, with applications in two different domains: causal inference and sublinear graph algorithms.
Addanki, Raghavendra K
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

G–PLIP: Knowledge graph neural network for structure-free protein–ligand bioactivity prediction

Computational and Structural Biotechnology Journal
Protein–ligand interactions (PLIs) determine the efficacy and safety profiles of small molecule drugs. Existing methods rely on either structural information or resource-intensive computations to predict PLI, casting doubt on whether it is possible to ...
Simon J. Crouzet, Anja Maria Lieberherr, Kenneth Atz, Tobias Nilsson, Lisa Sach-Peltason, Alex T. Müller, Matteo Dal Peraro, Jitao David Zhang   +7 more
doaj   +1 more source