Results 81 to 90 of about 250,057 (298)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Degree, closeness and eigenvector for the construction of cryptographically secure S-boxes

Ain Shams Engineering Journal
Facial identification systems are crucial in biometric security, making their protection against adversarial attacks essential. Ensuring the robustness of encryption methods in these systems is vital to prevent identity fraud and unauthorized access ...
Amal S. Alali, Muhammad Kamran Jamil, Rashad Ali, Refah Alotaibi, Wedad Albalawi   +4 more
doaj   +1 more source

Access control management with provenance in healthcare environments

, 2016
Provenance, describes how a data item came to be its current state. A Directed Acyclic Graph, nature of the provenance poses challenges to access control models and querying languages.
Hua Wang, Jianming Yong, Taotao Ma, Zhao, Yueai, Yueai Zhao, Yong, Jianming, Ma, Taotao, Wang, Hua, Cao, Jinli, Jinli Cao   +9 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Patterns of Service Utilization across the Full Continuum of Care: Using Patient Journeys to Assess Disparities in Access to Health Services

Knowledge
Healthcare organizations have a contractual obligation to the public to address population-level inequities to health services access and shed light on them. Various studies have focused on achieving equitable access to healthcare services for vulnerable
Jonas Bambi, Gracia Yunruo Dong, Yudi Santoso, Ken Moselle, Sophie Dugas, Kehinde Olobatuyi, Abraham Rudnick, Ernie Chang, Alex Kuo   +8 more
doaj   +1 more source

A Partitioning and Index Algorithm for RDF Data of Cloud-Based Robotic Systems

IEEE Access, 2018
Robotic systems generally employ resource description framework (RDF) to express heterogeneous data coming from different sensors. With the access of more terminals, the RDF volume in robotic systems is becoming larger and larger, posing new significant ...
Yonglin Leng, Zhikui Chen, Hongmin Wang, Fangming Zhong   +3 more
doaj   +1 more source

Sum graph based access structure in a secret sharing scheme

, 2006
Secret sharing scheme is a method to distribute secret information to a set P of participants so that only authorised subsets of P can reconstruct the secret.
Miller, Mirka, Slamet, Surjadi, Sugeng, Kiki Ariyanti   +2 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Generic Structure Extraction with Bi-Level Optimization for Graph Structure Learning

, 2022
Currently, most Graph Structure Learning (GSL) methods, as a means of learning graph structure, improve the robustness of GNN merely from a local view by considering the local information related to each edge and indiscriminately applying the mechanism ...
Zhigang Luo, Luo, Zhigang, Nan Yin, Yin, Nan   +3 more
core   +1 more source