Results 101 to 110 of about 5,808,675 (298)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Analyzing the Properties of Graph Neural Networks with Evolutionary Algorithms
MathematicsGraph Neural Networks (GNNs) have achieved remarkable success in graph structure learning, but recent research reveals their vulnerability to carefully designed perturbations.
Zhaowei Liu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Preface: optimization in graphs [PDF]
Journal of Combinatorial Optimization, 2013 We are honored to be Guest Editors of this special issue of Journal of Combinatorial Optimization dedicated to our friend Gerard Jennhwa Chang on the occasion of his 60th birthday. Gerard received his B.S. in mathematics from National Central University in Taiwan in 1974, and Ph.D. in operations research from Cornell University in USA in 1982.
D. J. Guan, Ko-Wei Lih, Xuding Zhu
openaire +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Proceedings of the 27th International Conference on Parallel Architectures and Compilation Techniques, 2018 Today's graphs used in domains such as machine learning or social network analysis may contain hundreds of billions of edges. Yet, they are not necessarily stored efficiently, and standard graph representations such as adjacency lists waste a significant number of bits while graph compression schemes such as WebGraph often require time-consuming ...
Besta, Maciej +5 more
openaire +2 more sources
GraphX: Unifying Data-Parallel and Graph-Parallel Analytics [PDF]
, 2014 From social networks to language modeling, the growing scale and importance of graph data has driven the development of numerous new graph-parallel systems (e.g., Pregel, GraphLab). By restricting the computation that can be expressed and introducing new
Crankshaw, Daniel +5 more
core
On Graph Stream Clustering with Side Information
, 2013 Graph clustering becomes an important problem due to emerging applications involving the web, social networks and bio-informatics. Recently, many such applications generate data in the form of streams.
Yu, Philip S., Zhao, Yuchen
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source