Results 101 to 110 of about 2,805,373 (250)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

WalkGCN: a biased sampling strategy for GNNs on non-attributed graphs

Journal of Big Data
Graph Neural Networks (GNNs) typically assume the presence of node attributes to capture interactions in a graph structure. However, real-world graph data often has incomplete or completely-missing attribute information.
Mincheol Shin, Taeyoung Choe, Yejong Ryu, Yanggon Kim, Mucheol Kim   +4 more
doaj   +1 more source

Collaborative Filtering Recommendation-Based Random Negative Sampling and Graph Attention

IEEE Access
In this era of information overload, recommendation systems significantly enhance the efficiency of information delivery, better meeting the needs of users. Currently, GCN-based recommendation systems typically use degree normalization or mean pooling to
Weiqiang Li, Xianghui Li, Xiaowen Liu, Xinhuan Chen, Ming Ma   +4 more
doaj   +1 more source

Forcing (G,D)-number of a Graph [PDF]

, 2011
By a graph G=(V,E), we mean a finite, undirected connected graph without loops and multiple ...
Nagarajan, A., A.Nagarajan, Palani, K., K.Palani   +3 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Sampling Method for Generalized Graph Signals With Pre-Selected Vertices via DC Optimization

IEEE Open Journal of Signal Processing
This paper proposes a method for vertex-wise aggregation sampling of a broad class of graph signals, designed to attain the best possible recovery based on the generalized sampling theory.
Keitaro Yamashita, Kazuki Naganuma, Shunsuke Ono   +2 more
doaj   +1 more source

Signed Graph Equation [PDF]

, 2009
For standard terminology and notion in graph theory we refer the reader to Harary [7]; the non-standard will be given in this paper as and when required.
Reddy, P. Siva Kota, P. Siva Kota Reddy, Subramanya, M. S., M. S. Subramanya   +3 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

PLM-guided incremental node sampling for inductive knowledge graph reasoning

Journal of King Saud University: Computer and Information Sciences
Inductive Knowledge Graph Reasoning (IKGR) aims to complete missing relations for emerging entities in knowledge graphs (KGs), with the core challenge lying in constructing a semantically rich yet structurally compact reasoning context.
Ling Wang, Yan Liu, Jicang Lu, Zhipeng Li   +3 more
doaj   +1 more source