Results 101 to 110 of about 184,942 (303)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Force-Directed Graph Layouts by Edge Sampling
, 2019 Recent work shows that sampling algorithms can be an effective tool for graph visualization. This paper extends prior work by applying edge sampling algorithms to speed up the spring force calculation in force-directed graph layout algorithms.
Robert Gove
core +2 more sources
Graph Sampling-Based Multi-Stream Enhancement Network for Visible-Infrared Person Re-Identification. [PDF]
Sensors (Basel), 2023 Jiang J +6 more
europepmc +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Unsupervised Embedding Learning for Large-Scale Heterogeneous Networks Based on Metapath Graph Sampling. [PDF]
Entropy (Basel), 2023 Zhong H, Wang M, Zhang X.
europepmc +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Graph signal sampling via reinforcement learning [PDF]
, 2018 Graph signal sampling is one the major problems in graph signal processing and arises in a variety of practical applications, such as data compression, image denoising and social network analysis.
Abramenko, Oleksii
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
We develop lagged Metropolis-Hastings walk for sampling from simple undirected graphs according to given stationary sampling probabilities. It is explained how the technique can be applied together with designed graphs for sampling of units-in-space ...
Zhang, Li-Chun
core +1 more source
Biclustering a dataset using photonic quantum computing
Frontiers in Computer ScienceBiclustering is a problem in machine learning and data mining that seeks to group together rows and columns of a dataset according to certain criteria. In this work, we highlight the natural relation that quantum computing models like boson and Gaussian ...
Ajinkya Borle, Ameya Bhave
doaj +1 more source