Results 91 to 100 of about 66,171 (303)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The Mortal Immortal graphic novel
This is a legacy output from the Mary Shelley Graphic Novel Workshop held at St. Nicholas CE Primary Academy in November 2023 as part of the Being Human Festival.
Stone, R., Schwochert, J., Civale, S.
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, 2014 Práce se zabývá novým literárním žánrem- grafickou novelou, která je po vizuální stránce podobná komiksové literatuře, avšak tématicky se od komiksů liší a je určena spíše dospělému publiku. Práce si na příkladu jedné grafické novely- Persepolis, dává za
Kochová, Nicole
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
VISUALISASI NOVEL BIOGRAFI HAMKA BERBASIS GRAPHIC NOVEL
, 2017 ABSTRAK Daniar, Aninditya. 2017. Visualisasi Novel Hamka berbasis Visual Novel.Skripsi, Program Studi Desain Komunikasi Visual, Jurusan Seni danDesain, Fakultas Sastra, Universitas Negeri Malang.Pembimbing (I) Dr. Hariyanto, M.Hum, (II)H.J.Hendrawan,S.Sn.
Aninditya Daniar; Mahasiswa
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Interactive Graphic Novel Experience
, 2013 Comics and Graphic Novels have been around for decades and within the last several years have been created to be displayed through the web as daily strips or larger works. Most of these works have held fast to the traditional format of Comics and Graphic
Havens, Sonia F.
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