Results 101 to 110 of about 66,171 (303)
Gomorra - La serie, esempio di transmedialità incompleta [PDF]
OculaNumerous scholars have debated the transmediality of Gomorrah - The Series, offering varying opinions. The thesis we aim to support is that this is a case of incomplete transmediality, primarily due to gaps in Sky Italia's promotional strategies ...
Maria Grazia Falà
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Superhuman Cognitions, Fourth Dimension and Speculative Comics Narrative
Fafnir, 2017 This article investigates the use of repeating panels in relation to speculative fiction storytelling in graphic novels Watchmen and From Hell, written by Alan Moore and illustrated by Dave Gibbons and Eddie Campbell, respectively.
Oskari Rantala
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
"Pictures and Conversations" Redefining the Graphic Novel
, 2021 Graphic Novel is a rather recent term, it marks distinct qualities of a group of artefacts to allow for differentiation and sales in late-modern (or post-modern) cultural context.
Dittmar, Jakob, Clavier, Berndt
core
Ayvali et Expecting : mémoire, espace et identités dans la bande dessinée
Cahiers BalkaniquesThe following article aims to analyze the way in which the experience of exile and the elements associated with it (memory, space, identity) are questioned through the ninth art which combines written discourse and images in a very dynamic and sensible ...
Charikleia Magdalini Kefalidou
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source