Results 101 to 110 of about 1,216,906 (379)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Discrete Mathematics, 1994 Suppose the vertices of the \(k\)-regular connected graph \(G_ n\) can be partitioned into two sets \(X\) and \(Y\) such that all vertex-degrees in the subgraphs induced by \(X\) and \(Y\) are at least \(\lceil k/2 \rceil\) and \(\lfloor k/2 \rfloor\), respectively.
openaire +3 more sources
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
A Cap For Graphic Scores. Graphic Notation And Performance
, 2017 Many graphic scores use the pitch versus time presentation, as a natural extension of the usual notation. In the general case, it displays discrete pitches, in a fixed timeline. Nevertheless, graphic scores use a lot of continuous lines, and the vertical dimension can be adapted to a particular performance.
Sluchin, Benny, Malt, Mikhail
openaire +2 more sources
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
An interactive graphics system to facilitate finite element structural analysis [PDF]
, 1973 The characteristics of an interactive graphics systems to facilitate the finite element method of structural analysis are described. The finite element model analysis consists of three phases: (1) preprocessing (model generation), (2) problem solution ...
Burk, R. C., Held, F. H.
core +1 more source
Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
Molecular Oncology, EarlyView.Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides +13 more
wiley +1 more source
Identifying tweets of personal health experience through word embedding and LSTM neural network
BMC Bioinformatics, 2018 Background As Twitter has become an active data source for health surveillance research, it is important that efficient and effective methods are developed to identify tweets related to personal health experience.
Keyuan Jiang +5 more
doaj +1 more source
Graphics calculators in upper secondary courses [PDF]
, 1995 This paper has been produced on request of the Secondary Education Authority, as part of a process of considering the potential impact of graphics calculators on upper secondary school courses.
Kissane, B.
core +1 more source