Results 11 to 20 of about 5,039,667 (217)

Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease [PDF]

open access: yes, 1996
To date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic ...
Wenzel, Björn E.   +2 more
core   +1 more source

The rs1990760 polymorphism within the IFIH 1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease [PDF]

open access: yes, 2009
Background: Three genes have been confirmed as major joint susceptibility genes for endocrine autoimmune disease:human leukocyte antigen class II, cytotoxic T-lymphocyte antigen 4 and protein tyrosine phosphatase non-receptor type 22.
Reisch, Nicole   +30 more
core   +1 more source

Graves' ophthalmopathy: interdisciplinary approach

open access: yesКлиническая и экспериментальная тиреоидология, 2010
Graves' ophthalmopathy constitutes a major therapeutic challenge, so specialists of various disci-plines have to combine their forces. According to the last consensus of EUGOGO (European Group On Graves' Orbitopathy) the treatment of choice for Graves ...

doaj   +1 more source

The change in the clinical presentation of Graves’ disease: a 30 years retrospective survey in an academic Brazilian tertiary center

open access: yesArchives of Endocrinology and Metabolism, 2020
Objective Graves’ disease (GD) is the main cause of hyperthyroidism among adults. It is an autoimmune condition classically marked by the Merserburg Triad (goiter, thyrotoxicosis, and orbitopathy), but the change in presentation of GD over time has ...
Wanesa Pinto   +4 more
doaj   +1 more source

A Genomic Point Mutation in the Extracellular Domain of the Thyrotropin Receptor in Patients with Graves’ Ophthalmopathy [PDF]

open access: yes, 1994
Orbital and pretibial fibroblasts are targets of autoimmune attack in Graves' ophthalmopathy (GO) and pretibial dermopathy (PTD). The fibroblast autoantigen involved in these peripheral manifestations of Graves' disease and the reason for the association
Sarkar, Gobinda   +4 more
core   +1 more source

Microchimerism and thyroid disorders: current knowledge and future prospects

open access: yesКлиническая и экспериментальная тиреоидология, 2015
This review will provide an overview of a novel phenomenon in medicine and endocrinology known as microchimerism (MC). MC is defined as the long-term presence of genetically distinct populations of cells in peripheral blood and tissues of individual ...
Ekaterina Arturovna Sabanova   +2 more
doaj   +1 more source

Advances in Graves' Disease [PDF]

open access: yesJournal of Thyroid Research, 2012
“From the very commencement the student should set out to witness the progress and effects of sickness and ought to persevere in the daily observation of disease during the whole period of his studies.” It was Dr. Robert J. Graves who used to pronounce this statement at the inauguration of his yearly university lectures in Dublin.
Premawardhana, L.D. (L. D.)   +3 more
openaire   +3 more sources

Rituximab in the treatment of Graves’ orbitopathy: latest updates and perspectives

open access: yesEndocrine Connections, 2022
Graves’ orbitopathy (GO) is a potentially sight-threatening and disfiguring, extrathyroidal manifestation of Graves’ disease. It often impairs patients’ qu ality of life, causing severe social and psychological sequelae.
Jakub Supronik   +3 more
doaj   +1 more source

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