Teprotumumab for Thyroid-Associated Ophthalmopathy [PDF]
New England Journal of Medicine, 2017 BACKGROUND: Thyroid-associated ophthalmopathy, a condition commonly associated with Graves’ disease, remains inadequately treated. Current medical therapies, which primarily consist of glucocorticoids, have limited efficacy and present safety concerns ...
Terry J Smith +2 more
exaly +3 more sources
Autophagy in graves’ ophthalmopathy [PDF]
Frontiers in Cell and Developmental Biology, 2023 Graves’ ophthalmopathy (GO) is an inflammatory autoimmune disease that affects the eyes. It can significantly alter the quality of life in patients because of its distinctive pathological appearance and the effect on vision.
Yu-Qing Chen +6 more
doaj +2 more sources
Increased percentage of L-selectin+ and ICAM-1+ peripheral blood CD4+/CD8+ T cells in active Graves' ophthalmopathy. [PDF]
Folia Histochemica et Cytobiologica, 2009 The purpose of the study was to evaluate the percentage of CD4+/CD8+ peripheral T cells expressing CD62L+ and CD54+ in patients with Graves' disease and to assess if these estimations could be helpful as markers of active ophthalmopathy.
Alina Bakunowicz-Lazarczyk +4 more
doaj +4 more sources
Graves’ ophthalmopathy: the clinical and psychosocial outcomes of different medical interventions – a systematic review [PDF]
BMJ Open OphthalmologyBackground Graves’ ophthalmopathy is a complex autoimmune disorder that can significantly affect quality of life (QoL), vision and physical appearance.
Maralyn Druce +2 more
doaj +2 more sources
An Appraisal of the Preventive Effect of Statins on the Development of Graves’ Ophthalmopathy: A Hospital-Based Cohort Study [PDF]
Ophthalmology and TherapyIntroduction Graves’ ophthalmopathy (GO) is an autoimmune inflammatory disorder observed in a substantial proportion of patients with Graves’ disease (GD), with debilitating symptoms of disfiguring, periorbital pain, dry eyes, diplopia, and even visual ...
Grace Chia-Yen Hsu +4 more
doaj +2 more sources
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2022 Graves' disease is an autoimmune thyroid disease with several characteristic symptoms and signs. Graves' ophthalmopathy, an inflammatory disease in the orbital area, is the main extrathyroid manifestation of Graves' disease.
Herry Krisnata Ginting, Soebagijo Adi
doaj +1 more source
Overview of Graves Ophthalmopathy Literature From 1999 to 2019: Bibliometric Analysis
Interactive Journal of Medical Research, 2021 BackgroundResearch on Graves ophthalmopathy has increased remarkably over the last 2 decades; however, few statistical analyses of the data presented in these publications have been conducted.
Jiamin Cao +5 more
doaj +1 more source
Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength [PDF]
, 2020 Natural autoantibodies to the IGF1 receptor (IGF1R-aAb) have been described in relation to Graves' ophthalmopathy. Other physiological roles of natural IGF1R-aAb are not known. We hypothesized that IGF1R-aAb may be related to muscle development.
Becker, Niels-Peter +7 more
core +1 more source
Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease [PDF]
, 1996 To date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic ...
Heufelder, Armin E. +2 more
core +1 more source
Extraocular muscle sampled volume in Graves' orbitopathy using 3-T fast spin-echo MRI with iterative decomposition of water and fat sequences [PDF]
, 2018 Background: Current magnetic resonance imaging (MRI) techniques for measuring extraocular muscle (EOM) volume enlargement are not ideally suited for routine follow-up of Graves’ ophthalmopathy (GO) because the difficulty of segmenting the muscles at ...
BRUSCOLINI, ALICE +4 more
core +1 more source