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Graves Orbitopathy [PDF]

Medicinska istrazivanja
Graves' orbitopathy (GO) represents eye changes that most often occur in patients with autoimmune hyperthyroidism-Graves' disease (GD), although they can also occur much less frequently in euthyroid and hypothyroid patients.
Fox TJ, Anastasopoulou C.
europepmc   +3 more sources

Significance of HLA in Graves’ disease and Graves’ orbitopathy in Asian and Caucasian populations – a systematic review

Frontiers in Immunology, 2023
IntroductionGraves’ disease (GD) and Graves’ orbitopathy (GO) development were suspected to be HLA-related in both Asian and Caucasian populations. However, most studies were performed with application of serological methods or low resolution genetic ...
Magdalena Stasiak, Bartłomiej Stasiak, Katarzyna Zawadzka-Starczewska, Andrzej Lewiński, Andrzej Lewiński   +4 more
doaj   +2 more sources

Current concepts regarding Graves’ orbitopathy [PDF]

Journal of Internal Medicine, 2022
Graves’ orbitopathy (GO) is an orbital autoimmune disorder and the main extrathyroidal manifestation of Graves’ disease, the most common cause of hyperthyroidism.
Luigi Bartalena, Maria Laura Tanda
openalex   +2 more sources

How Age Affects Graves’ Orbitopathy—A Tertiary Center Study [PDF]

Journal of Clinical Medicine
Purpose: Graves’ orbitopathy (GO) is an autoimmune disorder leading to inflammation, adipogenesis, and fibrosis. The severity of GO can vary widely among individuals, making it challenging to predict the natural course of the disease accurately, which is
Michael Oeverhaus, J Sander, Nicolai Smetana, Nikolaos E. Bechrakis, Neumann Inga, Karim Al-Ghazzawi, Ying Chen, Anja Eckstein   +7 more
openalex   +2 more sources

THE 2021 EUROPEAN GROUP ON GRAVES' ORBITOPATHY (EUGOGO) CLINICAL PRACTICE GUIDELINES FOR THE MEDICAL MANAGEMENT OF GRAVES' ORBITOPATHY.

European Journal of Endocrinology, 2021
Graves' orbitopathy (GO) is the main extrathyroidal manifestation of Graves' disease (GD). Choice of treatment should be based on assessment of clinical activity and severity of GO.
L. Bartalena, G. Kahaly, L. Baldeschi, C. Dayan, A. Eckstein, C. Marcocci, M. Marinò, B. Vaidya, W. Wiersinga   +8 more
semanticscholar   +1 more source

Muscle tendon elongation with bovine pericardium (Tutopatch®) in patients with Graves' orbitopathy; a prospective, observational, multicentre study. [PDF]

Acta Ophthalmol
Abstract Purpose Patients with severe ocular motility restriction and/or large angle strabismus due to Graves' orbitopathy (GO) cannot be adequately addressed with conventional strabismus surgery using large muscle recessions. Muscle tendon elongation surgery, using a spacer of bovine pericardium (Tutopatch®) has emerged as a valuable alternative.
Jellema HM, Oeverhaus M, Eckstein A, Mombaerts I, Kloos RJHM, Hartong DT, Nieuwkerk P, Saeed P.   +7 more
europepmc   +2 more sources

Role of genetics and epigenetics in Graves' orbitopathy. [PDF]

Eur Thyroid J
Objectives The pathogenesis of Graves’ orbitopathy (GO) remains to be fully elucidated. Here, we reviewed the role of genetics and epigenetics.
Marinò M, Rotondo Dottore G, Menconi F, Comi S, Cosentino G, Rocchi R, Latrofa F, Figus M, Santini F.   +8 more
europepmc   +2 more sources

Gut Microbiome Associated With Graves Disease and Graves Orbitopathy: The INDIGO Multicenter European Study

Journal of Clinical Endocrinology and Metabolism, 2023
Context Gut bacteria can influence host immune responses but little is known about their role in tolerance-loss mechanisms in Graves disease (GD; hyperthyroidism caused by autoantibodies, TRAb, to the thyrotropin receptor, TSHR) and its progression to ...
F. Biscarini, G. Masetti, I. Muller, H. Verhasselt, D. Covelli, G. Colucci, Lei Zhang, M. Draman, O. Okosieme, P. Taylor, C. Daumerie, M. Burlacu, M. Marinò, D. Ezra, P. Perros, S. Plummer, A. Eckstein, M. Salvi, J. Marchesi, M. Ludgate   +19 more
semanticscholar   +1 more source

A review of TSHR- and IGF-1R-related pathogenesis and treatment of Graves’ orbitopathy

Frontiers in Immunology, 2023
Graves’ orbitopathy (GO) is an organ-specific autoimmune disease, but its pathogenesis remains unclear. There are few review articles on GO research from the perspective of target cells and target antigens.
Xuejiao Cui, Futao Wang, Cong Liu
semanticscholar   +1 more source

Influence of biological sex, age and smoking on Graves’ orbitopathy – a ten-year tertiary referral center analysis

Frontiers in Endocrinology, 2023
Purpose Severity of Graves’ orbitopathy (GO) shows wide individual differences. For optimal treatment, it is important to be able to predict the natural course of the disease as accurate as possible to counteract with anti-inflammatory and surgical ...
Michael Oeverhaus, Luisa Winkler, K. Stähr, A. Daser, Nikolaos Bechrakis, Mareile Stöhr, Ying Chen, A. Eckstein   +7 more
semanticscholar   +1 more source