Results 51 to 60 of about 268,622 (261)

Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength [PDF]

, 2020
Natural autoantibodies to the IGF1 receptor (IGF1R-aAb) have been described in relation to Graves' ophthalmopathy. Other physiological roles of natural IGF1R-aAb are not known. We hypothesized that IGF1R-aAb may be related to muscle development.
Becker, Niels-Peter, Keller, Theresa, Kühnen, Peter, Minich, Waldemar B., Schomburg, Lutz, Schwiebert, Christian, Welsink, Tim, Wiegand, Susanna   +7 more
core   +1 more source

Rapamycin improves Graves’ orbitopathy by suppressing CD4+ cytotoxic T lymphocytes

JCI Insight, 2022
CD4+ cytotoxic T lymphocytes (CTLs) were recently implicated in immune-mediated inflammation and fibrosis progression of Graves’ orbitopathy (GO). However, little is known about therapeutic targeting of CD4+ CTLs.
Meng Zhang, K. Chong, Ziyi Chen, Hui Guo, Yu-feng Liu, Yongyong Kang, Yang Li, T. Shi, K. Lai, Mingqian He, Kai Ye, G. Kahaly, B. Shi, Yue Wang   +13 more
semanticscholar   +1 more source

Antioxidant Therapy in Graves’ Orbitopathy

Frontiers in Endocrinology, 2020
The balance of the cell redox state is a key point for the maintenance of cellular homeostasis. Increased reactive oxygen species (ROS) generation leads to oxidative damage of tissues, which is involved in the development of several diseases, including ...
Giulia Lanzolla, Claudio Marcocci, Michele Marinò   +2 more
doaj   +1 more source

Macrophage-Orbital Fibroblast Interaction and Hypoxia Promote Inflammation and Adipogenesis in Graves' Orbitopathy.

Endocrinology, 2022
The inflammatory eye disease Graves' orbitopathy (GO) is the main complication of autoimmune Graves' disease. In previous studies we have shown that hypoxia plays an important role for progression of GO.
Gina-Eva Görtz, S. Philipp, K. Bruderek, Christoph Jesenek, M. Horstmann, Y. Henning, Michael Oeverhaus, A. Daser, N. Bechrakis, A. Eckstein, S. Brandau, U. Berchner‐Pfannschmidt   +11 more
semanticscholar   +1 more source

Neural network-based method for diagnosis and severity assessment of Graves’ orbitopathy using orbital computed tomography

Scientific Reports, 2022
Computed tomography (CT) has been widely used to diagnose Graves’ orbitopathy, and the utility is gradually increasing. To develop a neural network (NN)-based method for diagnosis and severity assessment of Graves’ orbitopathy (GO) using orbital CT, a ...
Jaesung Lee, W. Seo, Jaegyun Park, W. Lim, J. Oh, N. Moon, Jeong Kyu Lee   +6 more
semanticscholar   +1 more source

Quality of life in Graves' orbitopathy [PDF]

Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor", 2011
The quality of life of patients with Graves' orbitopathy (GO) may be seriously damaged due to the changes in appearance, working abilities and everyday activities. The reasons for the deterioration in quality of life in GO are proptosis, diplopiae and/or
Ćirić Jasmina
doaj   +1 more source

Diagnostic accuracy of short-time inversion recovery sequence in Graves' ophthalmopathy before and after prednisone treatment [PDF]

, 2014
Introduction: In Graves' Ophthalmopathy, it is important to distinguish active inflammatory phase, responsive to immunosuppressive treatment, from fibrotic unresponsive inactive one.
Belfiore, M. P., Cappabianca, S., Carella, C., Cirillo, M., Cirillo, S., ELEFANTE, ANDREA, Prudente, M., Romano, F., Tortora, F.   +8 more
core   +1 more source

Insights into Ferroptosis: Targeting Glycolysis to Treat Graves' Orbitopathy.

Journal of Clinical Endocrinology and Metabolism, 2022
CONTEXT Oxidative stress plays an indispensable role in pathogenesis of Graves' orbitopathy (GO). Ferroptosis is a newly discovered form of cell death resulting from lipid peroxidation. Little is known about the role of ferroptosis in GO.
R. Ma, Lu Gan, Jie Guo, Zhiyue Peng, Jihong Wu, A. Harrison, J. Qian   +6 more
semanticscholar   +1 more source

Graves' orbitopathy treated with immunosuppressive therapy and orbital radiotherapy in a tertiary care endocrine centre: case series

Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 2016
Graves’ Orbitopathy (GO) is a localized entity of Graves’ disease, which is a challenging disease to treat. We describe 6 cases of moderate to severe GO who presented to our endocrine centre, with a mean age of 48.6 years and equal gender distribution ...
D. C. Kottahachchi, W. K. M. G. Amarawardena, N. A. S. Ariyawansa, S. Siyambalapitiya, K. A. Perera   +4 more
doaj   +1 more source

Isolated primary amyloidosis of the inferior rectus muscle mimicking Graves’ orbitopathy

Einstein (São Paulo)
The diagnosis of Graves’ orbitopathy is usually straightforward. However, orbital diseases that mimick some clinical signs of Graves’ orbitopathy may cause diagnostic confusion, particularly when associated to some form of thyroid dysfunction.
Mário Luiz Ribeiro Monteiro, Allan Christian Pieroni Gonçalves, Alanna Mara Pinheiro Sobreira Bezerra   +2 more
doaj   +1 more source