Results 51 to 60 of about 7,511 (159)

Increased percentage of L-selectin+ and ICAM-1+ peripheral blood CD4+/CD8+ T cells in active Graves' ophthalmopathy. [PDF]

, 2009
The purpose of the study was to evaluate the percentage of CD4+/CD8+ peripheral T cells expressing CD62L+ and CD54+ in patients with Graves' disease and to assess if these estimations could be helpful as markers of active ophthalmopathy.
A Bossowski, A De Bellis, A Heufelder, A Kretowski, A Modelska-Ziolkiewicz, A Pappa, A Pappa, Alina Bakunowicz-Lazarczyk, Anna Stasiak-Barmuta, G Foerster, G Kulig, G Liu, I Wakelkamp, I Wakelkamp, J Aniszewski, J Mysliwiec, Janusz Mysliwiec, L Bartalena, M Kazim, Maria Gorska, N Xia, P Boulos, Przemysław Pawlowski, R Bahn, S Yan, W Wiersinga   +25 more
core   +3 more sources

Exploring tear fluid biomarkers and the ocular surface in thyroid eye disease

Acta Ophthalmologica, Volume 104, Issue 1, Page e28-e38, February 2026.
Abstract Purpose To examine ocular surface changes and inflammatory tear fluid biomarkers in patients with thyroid eye disease (TED). Methods We included 106 Graves' disease (GD) patients (36 without TED, 32 with active and 38 with inactive TED) and 106 age‐ and sex‐matched healthy subjects for ophthalmological evaluation, including ocular surface ...
Mikael Thomassen Neset, Roy Miodini Nilsen, Kristian Løvås, Kathrine Halsøy, Håkon Reikvam, Ann‐Elin Meling Stokland, Grethe Åstrøm Ueland, Anette S. B. Wolff, Hans Christian D. Aass, Sjur Reppe, Eystein Sverre Husebye, Eyvind Rødahl, Tor Paaske Utheim, Hans Olav Ueland   +13 more
wiley   +1 more source

Neural Network-Based Pipeline With High-Resolution Feature Enhancement and Low-Resolution Feature Preservation for Automated Treatment Decision of Graves’ Orbitopathy Patients

IEEE Access
Graves’ orbitopathy is an inflammatory disorder that causes changes in different structures close to the eye. Accurate and consistent diagnoses are essential to improve the quality of life for Graves’ orbitopathy patients.
Sanghyuck Lee, Mohd Asyraf Zulkifley, Jeong Kyu Lee, Jaesung Lee   +3 more
doaj   +1 more source

Single‐Cell RNA Sequencing of Thyroid Tissues Reveals Pathogenesis of Graves' Disease

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Using single‐cell RNA sequencing and TCR profiling, this study constructed an immune cell atlas in thyroid tissue of Graves’ disease (GD), revealing dominant IFN‐γ‐secreting CD4+ T cells, expanded Tph and CD11c+ B cells, and enriched T/NK cells. Notably, GD thyroid follicular cells (TFCs) activated γδ T cells, which recruited cDC1 cells, suggesting a ...
Xiaoyi Zhou, Jia Cong, Rongguang Peng, Dichen Yang, Chenchen Dong, Jing Xie, Jiqi Yan, Jie Kuang, Fubin Li, Leng Siew Yeap, Xiaoyan Xie, Haolong Yin, Rulai Han, Liyun Shen, Yulin Zhou, Guang Ning, Shu Wang, Weiqing Wang, Lei Ye   +18 more
wiley   +1 more source

Graves’ orbitopathy: lessons from Representational Art

Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche, 2021
Graves’ orbitopathy (GO) is an autoimmune orbital disorder which occurs most commonly in patients with Graves’ disease,  less frequently in patients with chronic autoimmune thyroiditis.
Francesco Trimarchi, Enio Martino, Maria Laura Tanda, Luigi Bartalena   +3 more
doaj   +1 more source

Mesenchymal Stem Cell–Like Properties of Orbital Fibroblasts in Graves’ Orbitopathy [PDF]

, 2015
PURPOSE. Graves’ orbitopathy (GO) is a sight-threatening autoimmune disorder causing extraocular muscle fibrosis, upper lid retraction and eye bulging due to orbital fat expansion.
Bailly, M, Ezra, DG, Fitchett, C, Kozdon, K, Rose, GE   +4 more
core   +1 more source

Association of Individual or Family History of Autoimmune Disease With Future Development of Type 1 Diabetes

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 1, January 2026.
ABSTRACT Timely diagnosis of type 1 diabetes (T1D), especially in high‐risk populations, is crucial for preventing serious health complications. T1D is a chronic progressive autoimmune disease that has presymptomatic stages that can be identified through the detection of islet autoantibodies. Given that T1D is associated with other autoimmune diseases,
Nick Thomas, Bijay Vaidya, Richard David Leslie, Daniel Agardh, Richard Oram, Dana Dabelea, Arunjot Singh, Dimitrios Chantzichristos, Marian Rewers   +8 more
wiley   +1 more source

Life-threatening complications of high doses of intravenous methylprednisolone for treatment of Graves’ orbitopathy

Thyroid Research, 2019
Background Treatment of moderate to severe Graves’ orbitopathy (GO) is based mainly on intravenous pulses of methylprednisolone. High doses of methylprednisolone can exert several adverse effects, some of which might be life-threatening. The objective of
Dorota Walasik-Szemplińska, Grzegorz Kamiński, Iwona Sudoł-Szopińska   +2 more
doaj   +1 more source

Unexpected conversion from hypothyroidism to an euthyroid state due to Graves’ disease in a patient with an ectopic thyroid [PDF]

, 2013
A 15-year-old woman was diagnosed with hypothyroidism and unilateral ectopic thyroid. Levothyroxine treatment was introduced; however, the patient was non-compliant and took the medication irregularly.
Aleksandra Hernik, Ewelina Szczepanek-Parulska, Marek Ruchala   +2 more
core   +1 more source

PDGFRα+DPP4+ Fibroblasts‐Macrophage Crosstalk Induces Orbital Fibrosis in Treatment‐Resistant Thyroid Eye Disease via the GAS6‐AXL Pathway

Advanced Science, Volume 12, Issue 45, December 4, 2025.
This study elucidates macrophage‐induced orbital fibrosis in TED via the GAS6‐AXL pathway, a treatment‐resistant disorder lacking non‐surgical therapies. Using a novel patient cell‐derived orthotopic animal model of orbital fibrosis for TED, we repurpose an existing fibrosis therapy, addressing the absence of stable models and offering a potential ...
Lu Cheng, Jinwei Cheng, Guiling Liang, Xiaorui Wang, Yanwen Ge, Jiapei Liu, Luwei Cai, Hui Ying, Fenfen Wang, Jing Hu, Yufan Wang, Philipp E. Scherer, Ben Zhou, Mengle Shao, Fang Zhang   +14 more
wiley   +1 more source