Results 71 to 80 of about 379,363 (258)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An Ensemble Machine Learning Method for Alkali‐Activated Concrete Mix Ratio Analysis and Optimizing Experimental Results

Engineering Reports
In the field of civil engineering, the analysis of the composition of alkali‐sprayed concrete is of great significance for material research. However, there are currently no existing machine learning (ML) methods suitable for analyzing the composition of
Chengyuan Dai, Weiyu Li, Jiamin Lu, Yuelong Luo, Qizhou Liu, Lianxin Chen   +5 more
doaj   +1 more source

Effects of hydrothermal temperature on kaliophilite fillers and the fire resistance of geopolymers

Journal of Materials Research and Technology
Geopolymers exhibit significant application prospect in fireproofing owing to their thermal stability. This paper adopted the kaliophilite filler prepared at different hydrothermal temperatures to further enhance the fire resistance of geopolymers, and ...
Haoxuan Zhang, Jinbang Wang, Tongsheng Zhang, Yulong Liu, Zonghui Zhou, Xiuzhi Zhang, Yongbo Huang, Xiaolei Lu, Peng Du   +8 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Effect of fines content on liquefaction resistance of soil using laboratory test and SPT

Scientific Reports
Liquefaction is a severe earthquake-induced ground failure that reduces soil strength and foundation stability. This study examined the influence of fines content (FC) on soil liquefaction behaviour through field case histories and laboratory tests ...
Kongjian Li, Jungang Liu, Chunmei Mu, Yi Zhang, Lingxin Ge   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Axial Compressive Performance of CFRP-Confined Corroded Reinforced Concrete Columns

Buildings
In saline environments, it is difficult for reinforced concrete structures to meet normal durability requirements, which in turn affects the mechanical properties of the members.
Xiaochuan Chen, Banglu Xi, Yang Guo, Hanghang Liu, Dan Xu, Xun Zhang   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source