Results 41 to 50 of about 87,981 (248)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Green human resource management and shipping firms’ environmental performance: the serial mediating effects of seafarers’ organizational commitment and green behavior

Frontiers in Marine Science
This study empirically examines the relationships among green human resource management, seafarers’ organizational commitment, seafarers’ green behavior, and shipping firms’ environmental performance. It further explores the mediating roles of seafarers’
Jiaqi Liu, Jiaqi Liu, Hongbo Wang, Xin Wen, Hongyu Zhang, Yui-yip Lau, Qiong Chen, Xiaoming Zhou   +7 more
doaj   +1 more source

THE EFFECT OF GREEN HUMAN RESOURCE MANAGEMENT (GHRM) PRACTICES ON THE COMPETITIVENESS OF HIGHER EDUCATION MEDIATED BY KNOWLEDGE MANAGEMENT

Jurnal Aplikasi Manajemen, 2023
In the global era, creating competitiveness is one of the key aspects of survival. This study aims to explain competitiveness in knowledge management-mediated green human resource management practices in Jakarta's private universities.
Sukardi Sukardi, Djumarno Djumarno, Anik Herminingsih, Kasmir Kasmir, C. Catur Widayati, Zairil Zairil   +5 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Green Transformational Leadership, Organizational Commitment and Green Human Resource Management on Green Innovation Performance at the Government Sector

Journal of Human Resource Management
Purpose – The rapid growth of government and business sectors, organizations are always required to create various innovations, especially environmentally friendly innovations, in their human resources.
Yunita RAHMADANI, Asep Rokhyadi Permana SAPUTRA, Sri Muliati ABDULLAH   +2 more
doaj   +1 more source

Identifying the obstacles of green human resource management in order to increase the sustainability of the organization [PDF]

مدیریت و چشم انداز آموزش
The aim of the current research is to identify the obstacles of green human resource management in order to increase the sustainability of the organization.
Forozan Dolatyari, Abdullah Tavakoli
doaj   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

A bibliometric analysis of green human resource management based on scopus platform

Cogent Business & Management, 2020
The increasing research in protecting the environment has led to the emergence of a new research paradigm in the field of human resource management (HRM).
Muhammad Hamza Khan, Syaharizatul Noorizwan Muktar   +1 more
doaj   +1 more source