Results 61 to 70 of about 18,575 (207)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Molecular Tools for Monitoring Trichoderma in Agricultural Environments

Frontiers in Microbiology, 2018
Various Trichoderma species possess significance in agricultural systems as biofertilizers or biocontrol agents (BCAs). Besides these beneficial features, certain Trichoderma species can also act as agricultural pests, causing the green mold disease of ...
László Kredics, Liqiong Chen, Orsolya Kedves, Rita Büchner, Lóránt Hatvani, Henrietta Allaga, Viktor D. Nagy, Jamal M. Khaled, Naiyf S. Alharbi, Csaba Vágvölgyi, Csaba Vágvölgyi   +10 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Postharvest Biocontrol of Blue Mold in Shatangju Mandarins by the Antagonistic Yeast Meyerozyma guilliermondii SR1

Horticulturae
Blue mold caused by Penicillium italicum triggers severe tissue decay and limits postharvest shelf life, representing the primary constraint to the commercial supply chain of Shatangju mandarins (Citrus reticulata cv. Shatangju).
Feilong Yin, Ying Liu, Zhaoqing Ma, Xinli Yang, Lijun Zhu, Yang Cao, Yunfen Liu, Zhuoran Li, Tao Luo, Yujin Yuan, Liang Shuai   +10 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Biological Control of Citrus Postharvest Phytopathogens

Toxins, 2019
Citrus are vulnerable to the postharvest decay caused by Penicillium digitatum, Penicillium italicum, and Geotrichum citri-aurantii, which are responsible for the green mold, blue mold, and sour rot post-harvest disease, respectively.
Jaqueline Moraes Bazioli, João Raul Belinato, Jonas Henrique Costa, Daniel Yuri Akiyama, João Guilherme de Moraes Pontes, Katia Cristina Kupper, Fabio Augusto, João Ernesto de Carvalho, Taícia Pacheco Fill   +8 more
doaj   +1 more source

Taxonomy and control of <i>Trichoderma hymenopellicola</i> sp. nov. responsible for the first green mold disease on <i>Hymenopellis raphanipes</i>. [PDF]

Front Microbiol, 2022
Zeng XY, Yuan XX, Peng KQ, Pan YT, Tan TJ, Wu N, Tian FH.   +6 more
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source